Top

Published in:

Open Access 01-11-2016 | Original Article

Comparison of the Effects of Acute and Chronic Administration of Tetrahydroisoquinoline Amines on the In Vivo Dopamine Release: A Microdialysis Study in the Rat Striatum

Authors: Agnieszka Wąsik, Irena Romańska, Lucyna Antkiewicz-Michaluk

Published in: Neurotoxicity Research | Issue 4/2016

Abstract

The etiology of Parkinson’s disease (PD) may involve endogenous and exogenous factors. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), which was shown to be neurotoxic for dopaminergic neurons, is one of such factors, thus it can be used to construct an animal model of PD. In contrast, 1,2,3,4-tetrahydroisoquinoline (TIQ) and 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) produce neuroprotective effects acting as monoamino oxidase (MAO) inhibitors and free radical scavengers that reduce oxidative stress in the mammalian brain. In this study, we aimed to investigate the effects of neuroprotective compounds, TIQ and 1MeTIQ, on the dopamine release in vivo in an animal model of PD induced by chronic administration of 1BnTIQ (25 mg/kg i.p.). Using an in vivo microdialysis methodology, we measured the impact of both acute and chronic treatment with TIQ and 1MeTIQ (50 mg/kg i.p.) on 1BnTIQ-induced changes in dopamine release in the rat striatum. Additionally, the behavioral test was carried out to check the influence of repeated administrations of the investigated compounds on the locomotor activity of rats. The behavioral studies showed that the chronic administration of 1BnTIQ produced a significant elevation of exploratory locomotor activity, and both the investigated amines, TIQ and 1MeTIQ, administered together with 1BnTIQ completely prevented 1BnTIQ-produced hyperactivity. The in vivo microdialysis studies demonstrated that the chronic treatment with 1BnTIQ caused a significant and long-lasting increase in the dopamine release (approximately 300 %) to the extracellular space in the rat striatum, which was demonstrated in the basal samples 24 h after 1BnTIQ injection. The combined chronic administration of 1BnTIQ and the investigated compounds, TIQ or 1MeTIQ, completely antagonized the 1BnTIQ-induced essential disturbances of the dopamine releasing to the extracellular space in the striatum. In conclusion, we suggest that higher concentrations of 1BnTIQ in the brain produced distinct impairment in the dopamine release, whereas TIQ and 1MeTIQ (compounds with previously revealed neuroprotective properties) completely prevented 1BnTIQ-induced abnormalities in the function of dopamine neurons and restored the dopamine release to the control values.

Abe K, Taguchi K, Wasai T, Ren J, Utsunomiya I, Shinohara T, Miyatake T, Sano T (2001a) Biochemical and pathological study of endogenous 1-benzyl-1,2,3,4-tetrahydroisoquinoline-induced parkinsonism in the mouse. Brain Res 907:134–138CrossRefPubMed

Abe K, Taguchi K, Wasai T, Ren J, Utsunomiya I, Shinohara T, Miyatake T, Sano T (2001b) Stereoselective effect of (R)- and (S)- 1-methyl-1,2,3,4-tetrahydroisoquinolines on a mouse model of Parkinson’s disease. Brain Res Bull 56:55–60CrossRefPubMed

Abe K, Saitoh T, Horiguchi Y, Utsunomiya I, Taguchi K (2005) Synthesis and neurotoxicity of tetrahydroisoquinoline derivatives for studying Parkinson’s disease. Biol Pharm Bull 28:1355–1362CrossRefPubMed

Alachkar A, Brotchie JM, Jones OT (2010) Binding of dopamine and 3-methoxytyramine as L-DOPA metabolites to human α2-adrenergic and dopaminergic receptors. Neurosci Res 67:245–249CrossRefPubMed

Antkiewicz-Michaluk L, Michaluk J, Mokrosz M, Romańska I, Lorenc-Koci E, Otha S, Vetulani J (2001) Different action on dopamine catabolic pathways of two endogenous 1,2,3,4-tetrahydroisoquinolines with similar antidopaminergic properties. J Neurochem 78:100–108CrossRefPubMed

Antkiewicz-Michaluk L, Karolewicz B, Romańska I, Michaluk J, Bojarski AJ, Vetulani J (2003) 1-Methyl-1,2,3,4-tetrahydroisoquinoline protects against rotenone-induced mortality and biochemical changes in rat brain. Eur J Pharmacol 466:263–269CrossRefPubMed

Antkiewicz-Michaluk L, Wardas J, Michaluk J, Romańska I, Bojarski A, Vetulani J (2004) Protective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline against dopaminergic neurodegeneration in the extrapyramidal structures produced by intracerebral injection of rotenone. Inter J Neuropsychopharmacol 7:155–163CrossRef

Antkiewicz-Michaluk L, Łazarewicz JW, Patsenka A, Kajta M, Ziemińska E, Salińska E, Wąsik A, Gołembiowska K, Vetulani J (2006) The mechanism of 1,2,3,4-tetrahydroisoquinolines neuroprotection: the importance of free radicals scavenging properties and inhibition of glutamate-induced excitotoxicity. J Neurochem 97:846–856CrossRefPubMed

Antkiewicz-Michaluk L, Ossowska K, Romańska I, Michaluk J, Vetulani J (2008) 3-Methoxytyramine, an extraneuronal dopamine metabolite plays a physiological role in the brain as an inhibitory regulator of catecholaminergic activity. Eur J Pharmacol 599:32–35CrossRefPubMed

Antkiewicz-Michaluk L, Wąsik A, Romańska I, Michaluk J (2011) Both stereoselective (R)- and (S)-1-methyl-1,2,3,4-tetrahydroisoquinoline enantiomers protects striatal terminals against rotenone-induced suppression of dopamine release. Neurotox Res 20:134–149CrossRefPubMed

Egan MF, Karoum F, Wyatt RJ (1991) Effects of acute and chronic clozapine and haloperidol administration on 3-methoxytyramine accumulation in the rat prefrontal cortex, nucleus accumbens and striatum. Eur J Pharmacol 199:191–199CrossRefPubMed

Karoum F, Chrapusta SJ, Egan MF (1994) 3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in frontal cortex, nucleus accumbens and striatum by a simple two pool model. J Neurochem 63:972–978CrossRefPubMed

Kohta R, Kotake Y, Hosoya T, Hiramatsu T, Otsubo Y, Koyama H, Hirokane Y, Yokoyama Y, Ikeshoji H, Oofusa K, Suzuki M, Ohta S (2010) 1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination. J Neurochem 114:1291–1301PubMed

Kotake Y, Tasaki Y, Makino Y, Otha S, Hirobe M (1995) 1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: a novel endogenous amine in mouse brain and parkinsonian CSF. J Neurochem 65(6):2633–2638CrossRefPubMed

Kotake Y, Ohta S, Kanazawa I, Sakurai M (2003) Neurotoxicity of an endogenous brain amine, 1-benzyl-1,2,3,4-tetrahydroisoquinoline, in organotypic slice co-culture of mesencephalon and striatum. Neuroscience 117:63–70CrossRefPubMed

Kotake Y, Taguchi R, Okuda K, Sekiya Y, Tasaki Y, Hirobe M, Ohta S (2005) Neuroprotective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on cultured rat mesencephalic neurons in the presence or absence of various neurotoxins. Brain Res 1033(2):143–150CrossRefPubMed

Miller J, Selhub J, Joseph J (1996) Oxidative damage caused by free radicals produced during catecholamine autooxidation: protective effects of O-methylation and melatonin. Free Radic Biol Med 21:241–249CrossRefPubMed

Okada T, Shimada S, Sato K, Kotake Y, Kawai H, Ohta S, Tohyama M, Nishimura T (1998) Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine transporter expressed in HEK293 cells. Neurosci Res 30:87–90CrossRefPubMed

Patsenka A, Antkiewicz-Michaluk L (2004) Inhibition of rodent brain monoamine oxidase and tyrosine hydroxylase by endogenous compounds—1,2,3,4-tetrahydro-isoquinoline alkaloids. Pol J Pharmacol 56:727–734PubMed

Patsenka A, Michaluk J, Antkiewicz-Michaluk L (2004) 1,2,3,4-Tetrahydroisoquinoline alkaloids as endogenous inhibitors of brain monoamine oxidase, tyrosine hydroxylase and uptake of monoamines: in vitro study. In 13th international symposium on molecular and physiological aspects of regulatory processes of the organism. Kraków, Poland, Materials 2004, p 344

Shavali S, Ebadi M (2003) 1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), an endogenous neurotoxin, induces dopaminergic cell death through apoptosis. Neurotoxicology 24:417–424CrossRefPubMed

Singer TP, Ramsay RR (1995) Flauoprotein structure and mechanism 2. Monoamine oxidases: old friends hold many surprises. FASEB J 9(8):605–610PubMed

Wąsik A, Romańska I, Antkiewicz-Michaluk L (2009) 1-Benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous parkinsonism-inducing toxin, strongly potentiates MAO-dependent dopamine oxidation and impairs dopamine release: ex vivo and in vivo neurochemical studies. Neurotox Res 15:23–31

Wąsik A, Romańska I, Michaluk J, Kajta M, Antkiewicz-Michaluk L (2014) 1-Benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous neurotoxic compound, disturbs the behavioral and biochemical effects of l-DOPA: in vivo and ex vivo studies in the rat. Neurotox Res 26(3):240–254CrossRefPubMedPubMedCentral

Wąsik A, Romańska I, Michaluk J, Zelek-Molik A, Nalepa I, Antkiewicz-Michaluk L (2016) Neuroprotective effect of endogenous amine 1MeTIQ in animals model of Parkinson’s disease. Neurotox Res 29:351–363CrossRefPubMed

Yamakawa T, Ohta S (1997) Isolation of 1-methyl-1,2,3,4-tetrahydroisoquinoline-synthesizing enzyme from rat brain: a possible Parkinson’s disease-preventing enzyme. Biochem Biophys Res Commun 236:676–681CrossRefPubMed

Yamakawa T, Ohta S (1999) Biosynthesis of a parkinsonism-preventing substance, 1-methyl-1,2,3,4-tetrahydroisoquinoline, is inhibited by parkinsonism-inducing compounds in rat brain mitochondrial fraction. Neurosci Lett 259:157–160CrossRefPubMed

Yamakawa T, Kotake Y, Fujitani M, Shintani H, Makino Y, Ohta S (1999) Regional distribution of parkinsonism-preventing endogenous tetrahydroisoquinoline derivatives and an endogenous parkinsonism-preventing substance-synthesizing enzyme in monkey brain. Neurosci Lett 276:68–70CrossRefPubMed

Title: Comparison of the Effects of Acute and Chronic Administration of Tetrahydroisoquinoline Amines on the In Vivo Dopamine Release: A Microdialysis Study in the Rat Striatum
Authors: Agnieszka Wąsik
Irena Romańska
Lucyna Antkiewicz-Michaluk
Publication date: 01-11-2016
Publisher: Springer US
Published in: Neurotoxicity Research / Issue 4/2016
Print ISSN: 1029-8428
Electronic ISSN: 1476-3524
DOI: https://doi.org/10.1007/s12640-016-9661-1

2024 ASCO Annual Meeting

Springer Medicine

Comparison of the Effects of Acute and Chronic Administration of Tetrahydroisoquinoline Amines on the In Vivo Dopamine Release: A Microdialysis Study in the Rat Striatum

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 4/2016

Nanocapsules with Polyelectrolyte Shell as a Platform for 1,25-dihydroxyvitamin D3 Neuroprotection: Study in Organotypic Hippocampal Slices

Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Against Oxidative Stress in Zebrafish Hair Cells

The Influence of the CB1 Receptor Ligands on the Schizophrenia-Like Effects in Mice Induced by MK-801

Are Alcohol Anti-relapsing and Alcohol Withdrawal Drugs Useful in Cannabinoid Users?

Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in Rats

Nanomedicine to Overcome Current Parkinson’s Treatment Liabilities: A Systematic Review