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Supportive Care in Cancer
Published in: Supportive Care in Cancer 3/2012

01-03-2012 | Original Article

Comparison of pain response and functional interference outcomes between spinal and non-spinal bone metastases treated with palliative radiotherapy

Authors: Liang Zeng, Edward Chow, Liying Zhang, Shaelyn Culleton, Lori Holden, Florencia Jon, Luluel Khan, May Tsao, Elizabeth Barnes, Cyril Danjoux, Arjun Sahgal

Published in: Supportive Care in Cancer | Issue 3/2012

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Abstract

Purpose

The purpose of this study was to compare functional interference and pain response outcomes using the Brief Pain Inventory (BPI) for patients treated with palliative radiotherapy to spine versus non-spine bones and determine if dose fractionation was associated with each group’s respective response.

Materials and methods

Patients treated for painful bone metastases with palliative radiotherapy during May 2003 to June 2007 were analyzed. The BPI was utilized at baseline and monthly for 6 months post-radiation. Pain response was determined using International Bone Metastases Consensus response definitions. Wilcoxon rank–sum test (for continuous variable), Fisher exact test (for categorical value), and two-way analysis of variance were used for comparisons, and a p value of ≤0.05 was considered statistically significant.

Results

Three hundred eighty-six patients were analyzed, 62% were treated with a single fraction, 38% with multiple fractions. Pain and functional interference scores significantly improved over time in both spine and non-spine sites. At 3 months, 42% of all patients had a partial response, and 25% had a complete response. Location of bone metastases and radiotherapy dose were not predictive factors for pain response nor functional interference following radiation treatment.

Conclusion

Spine and non-spine bone metastases exhibited similar pain and functional interference improvements over a period of 6 months post-radiotherapy. There were, however, high attrition rates as expected with palliative studies, with approximately half the patients remaining in this study by 3 months and a fifth by 6 months. A single 8 Gy resulted in equal benefits in terms of both pain response and improvement in function.
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Metadata
Title
Comparison of pain response and functional interference outcomes between spinal and non-spinal bone metastases treated with palliative radiotherapy
Authors
Liang Zeng
Edward Chow
Liying Zhang
Shaelyn Culleton
Lori Holden
Florencia Jon
Luluel Khan
May Tsao
Elizabeth Barnes
Cyril Danjoux
Arjun Sahgal
Publication date
01-03-2012
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 3/2012
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-011-1144-6

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