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Supportive Care in Cancer
Published in: Supportive Care in Cancer 3/2012

Open Access 01-03-2012 | Review Article

Swallowing dysfunction in cancer patients

Authors: Judith E. Raber-Durlacher, Mike T. Brennan, Irma M. Verdonck-de Leeuw, Rachel J. Gibson, June G. Eilers, Tuomas Waltimo, Casper P. Bots, Marisol Michelet, Thomas P. Sollecito, Tanya S. Rouleau, Aniel Sewnaik, Rene-Jean Bensadoun, Monica C. Fliedner, Sol Silverman Jr, Fred K. L. Spijkervet, Dysphagia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)

Published in: Supportive Care in Cancer | Issue 3/2012

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Abstract

Purpose

Dysphagia (swallowing dysfunction) is a debilitating, depressing, and potentially life-threatening complication in cancer patients that is likely underreported. The present paper is aimed to review relevant dysphagia literature between 1990 and 2010 with a focus on assessment tools, prevalence, complications, and impact on quality of life in patients with a variety of different cancers, particularly in those treated with curative chemoradiation for head and neck cancer.

Methods

The literature search was limited to the English language and included both MEDLINE/PubMed and EMBASE. The search focused on papers reporting dysphagia as a side effect of cancer and cancer therapy. We identified relevant literature through the primary literature search and by articles identified in references.

Results

A wide range of assessment tools for dysphagia was identified. Dysphagia is related to a number of factors such as direct impact of the tumor, cancer resection, chemotherapy, and radiotherapy and to newer therapies such as epidermal growth factor receptor inhibitors. Concomitant oral complications such as xerostomia may exacerbate subjective dysphagia. Most literature focuses on head and neck cancer, but dysphagia is also common in other types of cancer.

Conclusions

Swallowing impairment is a clinically relevant acute and long-term complication in patients with a wide variety of cancers. More prospective studies on the course of dysphagia and impact on quality of life from baseline to long-term follow-up after various treatment modalities, including targeted therapies, are needed.
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Metadata
Title
Swallowing dysfunction in cancer patients
Authors
Judith E. Raber-Durlacher
Mike T. Brennan
Irma M. Verdonck-de Leeuw
Rachel J. Gibson
June G. Eilers
Tuomas Waltimo
Casper P. Bots
Marisol Michelet
Thomas P. Sollecito
Tanya S. Rouleau
Aniel Sewnaik
Rene-Jean Bensadoun
Monica C. Fliedner
Sol Silverman Jr
Fred K. L. Spijkervet
Dysphagia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)
Publication date
01-03-2012
Publisher
Springer-Verlag
Published in
Supportive Care in Cancer / Issue 3/2012
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-011-1342-2

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