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BMC Pediatrics

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Open Access 01-12-2024 | Patent Ductus Arteriosus | Research

Comparison of neurally adjusted ventilatory assist and synchronized intermittent mandatory ventilation in preterm infants after patent ductus arteriosus ligation: a retrospective study

Authors: Hui-Zi Lin, Yun-Feng Lin, Yi-Rong Zheng

Published in: BMC Pediatrics | Issue 1/2024

Abstract

Objective

This study aimed to compare the efficacy of neurally adjusted ventilatory assist (NAVA) to synchronized intermittent mandatory ventilation (SIMV) in preterm infants requiring mechanical ventilation after patent ductus arteriosus (PDA) ligation.

Methods

A retrospective analysis was conducted on intubated preterm infants who underwent PDA ligation at our hospital from July 2021 to January 2023. Infants were divided into NAVA or SIMV groups based on the ventilation mode after surgery.

Results

Fifty preterm infants were included. During treatment, peak inspiratory pressure (PIP) and mean airway pressure (MAP) were lower with NAVA compared to SIMV (PIP: 19.1 ± 2.9 vs. 22.4 ± 3.6 cmH₂O, P < 0.001; MAP: 9.1 ± 1.8 vs. 10.9 ± 2.7 cmH₂O, P = 0.002). PaO₂ and PaO₂/FiO₂ were higher with NAVA (PaO₂: 94.0 ± 11.7 vs. 84.8 ± 15.8 mmHg, P = 0.031; PaO₂/FiO₂: 267 [220–322] vs. 232 [186–290] mmHg, P = 0.025). Less sedation was required with NAVA (midazolam: 1.5 ± 0.5 vs. 1.1 ± 0.3 μg/kg/min, P < 0.001).

Conclusion

Compared to SIMV, early use of NAVA post PDA ligation in preterm infants was associated with decreased PIP and MAP. Early NAVA was also associated with reduced sedation needs and improved oxygenation. However, further studies are warranted to quantify the benefits of NAVA ventilation.

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Title: Comparison of neurally adjusted ventilatory assist and synchronized intermittent mandatory ventilation in preterm infants after patent ductus arteriosus ligation: a retrospective study
Authors: Hui-Zi Lin
Yun-Feng Lin
Yi-Rong Zheng
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Patent Ductus Arteriosus
Patent Ductus Arteriosus
Patent Ductus Arteriosus
Patent Ductus Arteriosus
Heart Surgery
Heart Surgery
Published in: BMC Pediatrics / Issue 1/2024
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/s12887-024-04727-w

At a glance: The STEP trials

Springer Medicine

Comparison of neurally adjusted ventilatory assist and synchronized intermittent mandatory ventilation in preterm infants after patent ductus arteriosus ligation: a retrospective study

Abstract

Objective

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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