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01-09-2014 | Clinical Study

Comparison of clinical outcomes and genomic characteristics of single focus and multifocal glioblastoma

Authors: Anna K. Paulsson, Jordan A. Holmes, Ann M. Peiffer, Lance D. Miller, Wennuan Liu, Jianfeng Xu, William H. Hinson, Glenn J. Lesser, Adrian W. Laxton, Stephen B. Tatter, Waldemar Debinski, Michael D. Chan

Published in: Journal of Neuro-Oncology | Issue 2/2014

Abstract

We investigate the differences in molecular signature and clinical outcomes between multiple lesion glioblastoma (GBM) and single focus GBM in the modern treatment era. Between August 2000 and May 2010, 161 patients with GBM were treated with modern radiotherapy techniques. Of this group, 33 were considered to have multiple lesion GBM (25 multifocal and 8 multicentric). Patterns of failure, time to progression and overall survival were compared based on whether the tumor was considered a single focus or multiple lesion GBM. Genomic groupings and methylation status were also investigated as a possible predictor of multifocality in a cohort of 41 patients with available tissue for analysis. There was no statistically significant difference in overall survival (p < 0.3) between the multiple lesion tumors (8.2 months) and single focus GBM (11 months). Progression free survival was superior in the single focus tumors (7.1 months) as compared to multi-focal (5.6 months, p = 0.02). For patients with single focus, multifocal and multicentric GBM, 81, 76 and 88 % of treatment failures occurred in the 60 Gy volume (p < 0.5), while 54, 72, and 38 % of treatment failures occurred in the 46 Gy volume (p < 0.4). Out of field failures were rare in both single focus and multiple foci GBM (7 vs 3 %). Genomic groupings and methylation status were not found to predict for multifocality. Patterns of failure, survival and genomic signatures for multiple lesion GBM do not appreciably differ when compared to single focus tumors.

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Title: Comparison of clinical outcomes and genomic characteristics of single focus and multifocal glioblastoma
Authors: Anna K. Paulsson
Jordan A. Holmes
Ann M. Peiffer
Lance D. Miller
Wennuan Liu
Jianfeng Xu
William H. Hinson
Glenn J. Lesser
Adrian W. Laxton
Stephen B. Tatter
Waldemar Debinski
Michael D. Chan
Publication date: 01-09-2014
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2014
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-014-1515-1

2024 ASCO Annual Meeting

Springer Medicine

Comparison of clinical outcomes and genomic characteristics of single focus and multifocal glioblastoma

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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