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01-09-2014 | Laboratory Investigation

Expression of Hedgehog ligand and signal transduction components in mutually distinct isocitrate dehydrogenase mutant glioma cells supports a role for paracrine signaling

Authors: Sunday A. Abiria, Thomas V. Williams, Alexander L. Munden, Vandana K. Grover, Ato Wallace, Christopher J. Lundberg, J. Gerardo Valadez, Michael K. Cooper

Published in: Journal of Neuro-Oncology | Issue 2/2014

Abstract

Hedgehog (Hh) signaling regulates the growth of malignant gliomas by a ligand-dependent mechanism. The cellular source of Sonic Hh ligand and mode of signaling have not been clearly defined due to the lack of methods to definitively identify neoplastic cells in glioma specimens. Using an antibody specific for mutant isocitrate dehydrogenase protein expression to identify glioma cells, we demonstrate that Sonic Hh ligand and the pathway components Patched1 (PTCH1) and GLI1 are expressed in neoplastic cells. Further, Sonic Hh ligand and its transcriptional targets, PTCH1 and GLI1, are expressed in mutually distinct populations of neoplastic cells. These findings support a paracrine mode of intratumoral Hh signaling in malignant gliomas.

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Title: Expression of Hedgehog ligand and signal transduction components in mutually distinct isocitrate dehydrogenase mutant glioma cells supports a role for paracrine signaling
Authors: Sunday A. Abiria
Thomas V. Williams
Alexander L. Munden
Vandana K. Grover
Ato Wallace
Christopher J. Lundberg
J. Gerardo Valadez
Michael K. Cooper
Publication date: 01-09-2014
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2014
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-014-1481-7

2024 ASCO Annual Meeting

Springer Medicine

Expression of Hedgehog ligand and signal transduction components in mutually distinct isocitrate dehydrogenase mutant glioma cells supports a role for paracrine signaling

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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