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European Radiology
Published in: European Radiology 6/2014

01-06-2014 | Magnetic Resonance

Comparison of ASL and DCE MRI for the non-invasive measurement of renal blood flow: quantification and reproducibility

Authors: Marica Cutajar, David L. Thomas, Patrick W. Hales, T. Banks, Christopher A. Clark, Isky Gordon

Published in: European Radiology | Issue 6/2014

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Abstract

Objectives

To investigate the reproducibility of arterial spin labelling (ASL) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and quantitatively compare these techniques for the measurement of renal blood flow (RBF).

Methods

Sixteen healthy volunteers were examined on two different occasions. ASL was performed using a multi-TI FAIR labelling scheme with a segmented 3D-GRASE imaging module. DCE MRI was performed using a 3D-FLASH pulse sequence. A Bland-Altman analysis was used to assess repeatability of each technique, and determine the degree of correspondence between the two methods.

Results

The overall mean cortical renal blood flow (RBF) of the ASL group was 263 ± 41 ml min−1 [100 ml tissue]−1, and using DCE MRI was 287 ± 70 ml min−1 [100 ml tissue]−1. The group coefficient of variation (CVg) was 18 % for ASL and 28 % for DCE-MRI. Repeatability studies showed that ASL was more reproducible than DCE with CVgs of 16 % and 25 % for ASL and DCE respectively. Bland-Altman analysis comparing the two techniques showed a good agreement.

Conclusions

The repeated measures analysis shows that the ASL technique has better reproducibility than DCE-MRI. Difference analysis shows no significant difference between the RBF values of the two techniques.

Key Points

• Reliable non-invasive monitoring of renal blood flow is currently clinically unavailable.
• Renal arterial spin labelling MRI is robust and repeatable.
• Renal dynamic contrast-enhanced MRI is robust and repeatable.
• ASL blood flow values are similar to those obtained using DCE-MRI.
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Metadata
Title
Comparison of ASL and DCE MRI for the non-invasive measurement of renal blood flow: quantification and reproducibility
Authors
Marica Cutajar
David L. Thomas
Patrick W. Hales
T. Banks
Christopher A. Clark
Isky Gordon
Publication date
01-06-2014
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 6/2014
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3130-0

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