Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
AIDS Research and Therapy
Published in: AIDS Research and Therapy 1/2014

Open Access 01-12-2014 | Short report

Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection

Authors: Yanmei Jiao, Xin Sun, Xiaojie Huang, Wei Li, Tong Zhang, Hao Wu

Published in: AIDS Research and Therapy | Issue 1/2014

Login to get access

Abstract

The role of DCs in primary HIV-1 infection remains uncertain. In this study, we enrolled two different groups of subjects with acute HIV-1 infection. One group progressed to CD4 counts below 200 cells/μl within 2 years of HIV-1 infection (CD4 Low Group), while the other group maintained CD4 counts above 500 cells/μl (CD4 High Group). We did not find statistical difference in the pDC number between the two groups during acute HIV-1 infection. However, the mDC number was significantly lower in the CD4 Low Group than in the CD4 High Group.
Appendix
Available only for authorised users
Literature
1.
Lehman TL, O’Halloran KP, Hoover EA, Avery PR: Utilizing the FIV model to understand dendritic cell dysfunction and the potential role of dendritic cell immunization in HIV infection. Vet Immunol Immunopathol. 2010, 134: 75-81. 10.1016/j.vetimm.2009.10.012PubMedCentralCrossRefPubMed
2.
Jiao Y, Zhang T, Wang R, Zhang H, Huang X, Yin J, Zhang L, Xu X, Wu H: Plasma IP-10 is associated with rapid disease progression in early HIV-1 infection. Viral Immunol. 2012, 25: 333-337. 10.1089/vim.2012.0011CrossRefPubMed
3.
Fiebig EW, Wright DJ, Rawal BD, Garrett PE, Schumacher RT, Peddada L, Heldebrant C, Smith R, Conrad A, Kleinman SH, Busch MP: Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS. 2003, 17: 1871-1879. 10.1097/00002030-200309050-00005CrossRefPubMed
4.
Pacanowski J, Kahi S, Baillet M, Lebon P, Deveau C, Goujard C, Meyer L, Oksenhendler E, Sinet M, Hosmalin A: Reduced blood CD123+ (lymphoid) and CD11c + (myeloid) dendritic cell numbers in primary HIV-1 infection. Blood. 2001, 98: 3016-3021. 10.1182/blood.V98.10.3016CrossRefPubMed
5.
Zhang M, Zhang H, Zhang T, Ji Y, Jiao Y, Wu H: Longitudinal changes of peripheral blood DC subsets and regulatory T cells in Chinese chronic HIV-1-infected patients during antiretroviral therapy. PLoS One. 2012, 7: e37966- 10.1371/journal.pone.0037966PubMedCentralCrossRefPubMed
6.
McMichael AJ, Borrow P, Tomaras GD, Goonetilleke N, Haynes BF: The immune response during acute HIV-1 infection: clues for vaccine development. Nat Rev Immunol. 2010, 10: 11-23.PubMedCentralCrossRefPubMed
7.
Killian MS, Fujimura SH, Hecht FM, Levy JA: Similar changes in plasmacytoid dendritic cell and CD4 T-cell counts during primary HIV-1 infection and treatment. AIDS. 2006, 20: 1247-1252. 10.1097/01.aids.0000232231.34253.bdCrossRefPubMed
8.
Schmidt B, Fujimura SH, Martin JN, Levy JA: Variations in plasmacytoid dendritic cell (PDC) and myeloid dendritic cell (MDC) levels in HIV-infected subjects on and off antiretroviral therapy. J Clin Immunol. 2006, 26: 55-64. 10.1007/s10875-006-8401-3CrossRefPubMed
9.
Donaghy H, Pozniak A, Gazzard B, Qazi N, Gilmour J, Gotch F, Patterson S: Loss of blood CD11c (+) myeloid and CD11c (-) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load. Blood. 2001, 98: 2574-2576. 10.1182/blood.V98.8.2574CrossRefPubMed
10.
Meyers JH, Justement JS, Hallahan CW, Blair ET, Sun YA, O’Shea MA, Roby G, Kottilil S, Moir S, Kovacs CM, Chun TW, Fauci AS: Impact of HIV on cell survival and antiviral activity of plasmacytoid dendritic cells. PLoS One. 2007, 2: e458- 10.1371/journal.pone.0000458PubMedCentralCrossRefPubMed
11.
12.
Takaori-Kondo A: APOBEC family proteins: novel antiviral innate immunity. Int J Hematol. 2006, 83: 213-216. 10.1532/IJH97.05187CrossRefPubMed
Metadata
Title
Compare mDCs and pDCs between two distinct patients groups in acute HIV-1 infection
Authors
Yanmei Jiao
Xin Sun
Xiaojie Huang
Wei Li
Tong Zhang
Hao Wu
Publication date
01-12-2014
Publisher
BioMed Central
Published in
AIDS Research and Therapy / Issue 1/2014
Electronic ISSN: 1742-6405
DOI
https://doi.org/10.1186/1742-6405-11-22

Other articles of this Issue 1/2014

AIDS Research and Therapy 1/2014 Go to the issue

Short report

The D-amino acid peptide D3 reduces amyloid fibril boosted HIV-1 infectivity

Case report

Successful use of extracorporeal membrane oxygenation in a human immunodeficiency virus infected patient with severe acute respiratory distress syndrome

Research

Levels of circulating myeloid subpopulations and of heme oxygenase-1 do not predict CD4+ T cell recovery after the initiation of antiretroviral therapy for HIV disease

Research

German cohort of HCV mono-infected and HCV/HIV co-infected patients reveals relative under-treatment of co-infected patients

Research

Hyperlactatemia in a group of HIV patients living in Yaounde-Cameroon

Research

Differential glycosylation of envelope gp120 is associated with differential recognition of HIV-1 by virus-specific antibodies and cell infection
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits