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Published in: Malaria Journal 1/2004

Open Access 01-12-2004 | Research

Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso

Authors: Olaf Mueller, Oliver Razum, Corneille Traore, Bocar Kouyate

Published in: Malaria Journal | Issue 1/2004

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Abstract

Background

There is little information on the effectiveness of modern compared to traditional malaria treatment from the rural areas of Africa.

Methods

Follow-up of 402 episodes of clinical malaria among pre-school children in Nouna Health District, northwestern Burkina Faso. The exposure of interest was the type of treatment (chloroquine versus traditional); the outcome was clinical response to treatment.

Results

Out of the 402 observed malaria episodes, 87% were treated with chloroquine and 13% with traditional remedies. Overall, community effectiveness was 67% with chloroquine and 54% with traditional treatment. Chloroquine effectiveness was associated with age and ethnicity. An additional interview survey demonstrated wide variations in the dosages of chloroquine given to young children in this community.

Conclusions

The effectiveness of chloroquine, when used within the community, was significantly lower in this study than its known efficacy in the study area. This concerns, in particular, the very young children. These findings demonstrate the need for better education of parents about correct dosage of first-line malaria drugs, and for particular attention in the treatment of very young children.
Literature
1.
go back to reference Greenwood B, Bradley A, Greenwood A, Byass P, Jammeh K, Marsh K, Tulloch F, Oldfield F, Hayes R: Mortality and morbidity from malaria among children in a rural area of The Gambia. Trans R Soc Trop Med Hyg. 1987, 81: 478-486. 10.1016/0035-9203(87)90170-2.CrossRefPubMed Greenwood B, Bradley A, Greenwood A, Byass P, Jammeh K, Marsh K, Tulloch F, Oldfield F, Hayes R: Mortality and morbidity from malaria among children in a rural area of The Gambia. Trans R Soc Trop Med Hyg. 1987, 81: 478-486. 10.1016/0035-9203(87)90170-2.CrossRefPubMed
2.
go back to reference WHO: World malaria situation in 1994. Wkly Epidemiol Rec. 1997, 72: 269-292. WHO: World malaria situation in 1994. Wkly Epidemiol Rec. 1997, 72: 269-292.
3.
go back to reference Snow RW, Craig M, Deichmann U, Marsh K: Estimating mortality, morbidity and disability due to malaria among Africa's non-pregnant population. Bull World Health Organ. 1999, 77: 624-640.PubMedCentralPubMed Snow RW, Craig M, Deichmann U, Marsh K: Estimating mortality, morbidity and disability due to malaria among Africa's non-pregnant population. Bull World Health Organ. 1999, 77: 624-640.PubMedCentralPubMed
4.
go back to reference Müller O, Traoré C, Kouyaté B, Becher H: Malaria morbidity, treatment seeking behaviour, and mortality in a cohort of young children in rural Burkina Faso. Trop Med Int Health. 2003, 8: 290-296.CrossRefPubMed Müller O, Traoré C, Kouyaté B, Becher H: Malaria morbidity, treatment seeking behaviour, and mortality in a cohort of young children in rural Burkina Faso. Trop Med Int Health. 2003, 8: 290-296.CrossRefPubMed
5.
go back to reference McCombie SC: Self-treatment for malaria: the evidence and methodological issues. Health Policy Plan. 2002, 17: 333-344. 10.1093/heapol/17.4.333.CrossRefPubMed McCombie SC: Self-treatment for malaria: the evidence and methodological issues. Health Policy Plan. 2002, 17: 333-344. 10.1093/heapol/17.4.333.CrossRefPubMed
6.
go back to reference Pagnoni F, Convelbo N, Tiendrebeogo J, Cousens S, Esposito F: A community-based programme to provide promt and adequate treatment of presumptive malaria in children. Trans R Soc Trop Med Hyg. 1997, 91: 512-517. 10.1016/S0035-9203(97)90006-7.CrossRefPubMed Pagnoni F, Convelbo N, Tiendrebeogo J, Cousens S, Esposito F: A community-based programme to provide promt and adequate treatment of presumptive malaria in children. Trans R Soc Trop Med Hyg. 1997, 91: 512-517. 10.1016/S0035-9203(97)90006-7.CrossRefPubMed
7.
go back to reference Kidane G, Morrow RH: Teaching mothers to provide home treatment of malaria in Tigray, Ethiopia: a randomised trial. Lancet. 2000, 356: 550-55. 10.1016/S0140-6736(00)02580-0.CrossRefPubMed Kidane G, Morrow RH: Teaching mothers to provide home treatment of malaria in Tigray, Ethiopia: a randomised trial. Lancet. 2000, 356: 550-55. 10.1016/S0140-6736(00)02580-0.CrossRefPubMed
8.
go back to reference Trape J: The public health impact of chloroquine resistance in Africa. Am J Trop Med Hyg. 2001, 64 (1-2 Suppl): 12-17.PubMed Trape J: The public health impact of chloroquine resistance in Africa. Am J Trop Med Hyg. 2001, 64 (1-2 Suppl): 12-17.PubMed
9.
go back to reference Krause G, Sauerborn R: Community-effectiveness of care – the example of malaria treatment in rural Burkina Faso. Ann Trop Paediatr. 2000, 7: 99-106. Krause G, Sauerborn R: Community-effectiveness of care – the example of malaria treatment in rural Burkina Faso. Ann Trop Paediatr. 2000, 7: 99-106.
10.
go back to reference Guigemdé TR, Aoba A, Ouedraogo JB, Lamizana L: Ten-year surveillance of drug-resistant malaria in Burkina Faso (1982–1991). Am J Trop Med Hyg. 1993, 50: 699-704. Guigemdé TR, Aoba A, Ouedraogo JB, Lamizana L: Ten-year surveillance of drug-resistant malaria in Burkina Faso (1982–1991). Am J Trop Med Hyg. 1993, 50: 699-704.
11.
go back to reference Müller O, Traoré C, Kouyaté B: Clinical efficacy of chloroquine in young children with uncomplicated malaria – a community based study in rural Burkina Faso. Trop Med Int Health. 2003, 8: 202-203.CrossRefPubMed Müller O, Traoré C, Kouyaté B: Clinical efficacy of chloroquine in young children with uncomplicated malaria – a community based study in rural Burkina Faso. Trop Med Int Health. 2003, 8: 202-203.CrossRefPubMed
12.
go back to reference Orwa JA: Editorial. Herbal medicine in Kenya: Evidence of safety and efficacy. East Afr Med J. 2002, 341-342. Orwa JA: Editorial. Herbal medicine in Kenya: Evidence of safety and efficacy. East Afr Med J. 2002, 341-342.
13.
go back to reference Okrah J, Traoré C, Palé A, Sommerfeld J, Müller O: Community factors associated with malaria prevention by mosquito nets: an exploratory study in rural Burkina Faso. Trop Med Int Health. 2002, 7: 240-248. 10.1046/j.1365-3156.2002.00856.x.CrossRefPubMed Okrah J, Traoré C, Palé A, Sommerfeld J, Müller O: Community factors associated with malaria prevention by mosquito nets: an exploratory study in rural Burkina Faso. Trop Med Int Health. 2002, 7: 240-248. 10.1046/j.1365-3156.2002.00856.x.CrossRefPubMed
14.
go back to reference Müller O, Becher H, Baltussen A, Ye Y, Diallo D, Konate M, Gbangou A, Kouyate B, Garenne M: Effect of zinc supplementation on malaria morbidity among West African children: a randomized double-blind placebo-controlled trial. BMJ. 2001, 322: 1567-1572. 10.1136/bmj.322.7302.1567.PubMedCentralCrossRefPubMed Müller O, Becher H, Baltussen A, Ye Y, Diallo D, Konate M, Gbangou A, Kouyate B, Garenne M: Effect of zinc supplementation on malaria morbidity among West African children: a randomized double-blind placebo-controlled trial. BMJ. 2001, 322: 1567-1572. 10.1136/bmj.322.7302.1567.PubMedCentralCrossRefPubMed
15.
go back to reference WHO: Assessment of therapeutic efficacy of antimalarial drugs for uncomplicated falciparum malaria in areas with intense transmission. 1996, Geneva: World Health Organization WHO/MAL/96.1077 WHO: Assessment of therapeutic efficacy of antimalarial drugs for uncomplicated falciparum malaria in areas with intense transmission. 1996, Geneva: World Health Organization WHO/MAL/96.1077
16.
go back to reference Jahn , Razum : Observational studies for intervention assessment. Lancet. 2001, 357: 2141-10.1016/S0140-6736(00)05218-1.CrossRefPubMed Jahn , Razum : Observational studies for intervention assessment. Lancet. 2001, 357: 2141-10.1016/S0140-6736(00)05218-1.CrossRefPubMed
17.
go back to reference Bugmann N: Le concept du paludisme, l'usage et l'efficacité in vivo de trois traitements traditionnels antipalustres dans la Région de Dori, Burkina Faso. PhD Thesis. 2000, University of Basel Bugmann N: Le concept du paludisme, l'usage et l'efficacité in vivo de trois traitements traditionnels antipalustres dans la Région de Dori, Burkina Faso. PhD Thesis. 2000, University of Basel
18.
go back to reference Hamer DH, MacLeod WB, Addo-Yobo E, Duggan CP, Estrella B, Fawzi WW, Konde-Lule JK, Mwanakasale V, Premji ZG, Sempértegui F, Ssengooba FP, Yeboh-Antwi K, Simon JL: Age, temperature, and parasitaemia predict chloroquine treatment failure and anaemia in children with uncomplicated Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg. 2004, 97: 422-428. 10.1016/S0035-9203(03)90076-9.CrossRef Hamer DH, MacLeod WB, Addo-Yobo E, Duggan CP, Estrella B, Fawzi WW, Konde-Lule JK, Mwanakasale V, Premji ZG, Sempértegui F, Ssengooba FP, Yeboh-Antwi K, Simon JL: Age, temperature, and parasitaemia predict chloroquine treatment failure and anaemia in children with uncomplicated Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg. 2004, 97: 422-428. 10.1016/S0035-9203(03)90076-9.CrossRef
19.
go back to reference Djimde A, Plowe CV, Diop S, Dicko A, Wellems TE, Doumbo O: Use of atimalarial drugs in Mali: policy versus reality. Am J Trop Med Hyg. 1998, 59: 376-379.PubMed Djimde A, Plowe CV, Diop S, Dicko A, Wellems TE, Doumbo O: Use of atimalarial drugs in Mali: policy versus reality. Am J Trop Med Hyg. 1998, 59: 376-379.PubMed
20.
go back to reference Nsimba SED, Warsame M, Tomson G, Massele AY, Mbatiya ZA: A household survey of source, availability, and use of antimalarials in a rural area of Tanzania. Drug Inf J. 1999, 33: 1025-1032. Nsimba SED, Warsame M, Tomson G, Massele AY, Mbatiya ZA: A household survey of source, availability, and use of antimalarials in a rural area of Tanzania. Drug Inf J. 1999, 33: 1025-1032.
21.
go back to reference Okonkwo PO, Akpala CO, Okafor HU, Mbah AU, Nwaiwu O: Compliance to correct dose of chloroquine in uncomplicated malaria correlates with improvement in the condition of rural Nigerian children. Trans R Soc Trop Med Hyg. 2001, 95: 320-24. 10.1016/S0035-9203(01)90252-4.CrossRefPubMed Okonkwo PO, Akpala CO, Okafor HU, Mbah AU, Nwaiwu O: Compliance to correct dose of chloroquine in uncomplicated malaria correlates with improvement in the condition of rural Nigerian children. Trans R Soc Trop Med Hyg. 2001, 95: 320-24. 10.1016/S0035-9203(01)90252-4.CrossRefPubMed
22.
go back to reference Abdel-Hameed AA: Malaria case management at the community level in Gezira, Sudan. Afr J Med Sci. 2001, 30 (supplement): 43-46. Abdel-Hameed AA: Malaria case management at the community level in Gezira, Sudan. Afr J Med Sci. 2001, 30 (supplement): 43-46.
24.
go back to reference Traoré C: Epidemiology of malaria in a holoendemic area of rural Burkina Faso. PhD Thesis. 2003, University of Heidelberg Traoré C: Epidemiology of malaria in a holoendemic area of rural Burkina Faso. PhD Thesis. 2003, University of Heidelberg
Metadata
Title
Community effectiveness of chloroquine and traditional remedies in the treatment of young children with falciparum malaria in rural Burkina Faso
Authors
Olaf Mueller
Oliver Razum
Corneille Traore
Bocar Kouyate
Publication date
01-12-2004
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2004
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-3-36

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