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Tumor Biology
Published in: Tumor Biology 5/2014

01-05-2014 | Research Article

Common variation rs6983267 at 8q24.1 and risk of colorectal adenoma and cancer: evidence based on 31 studies

Authors: Yin-Ping Wang, Jie Zhang, Hong-Yi Zhu, Chang-Ling Qian, Hua Liu, Fu Ji, Zhi-Yong Shen

Published in: Tumor Biology | Issue 5/2014

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Abstract

Genome-wide association studies have identified 8q24.21-rs6983267 as a new colorectal cancer (CRC) and colorectal adenoma (CRA) susceptibility locus in populations of European descent. Since then, the relationship between 8q24.21-rs6983267 and CRC/CRA has been reported in various ethnic groups; however, these studies have yielded inconsistent results. To investigate this inconsistency and derive a more precise estimation of the relationship, we conducted a meta-analysis of 31 studies, including 51,293 cases and 58,962 controls for CRC, and 8,148 cases and 17,065 controls for CRA. Potential sources of heterogeneity and publication bias were also systematically explored. Overall, the summary odds ratio of G variant for CRC was 1.18 (95 % CI, 1.16–1.21; P < 10−5) and 1.17 (95 % CI, 1.11–1.23; P < 10−5) for CRA. Significant results were observed using dominant or recessive genetic model for the polymorphism. In the subgroup analysis by ethnicity, significantly increased risks were found in East Asians and Caucasian populations; while no significant associations were detected among African Americans. After stratifying by sample size and control source, significant associations were also obtained. This meta-analysis suggests that the 8q24.21-rs6983267 polymorphism is associated with CRC/CRA susceptibility, but these associations vary in different ethnic populations.
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Metadata
Title
Common variation rs6983267 at 8q24.1 and risk of colorectal adenoma and cancer: evidence based on 31 studies
Authors
Yin-Ping Wang
Jie Zhang
Hong-Yi Zhu
Chang-Ling Qian
Hua Liu
Fu Ji
Zhi-Yong Shen
Publication date
01-05-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 5/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-013-1532-2

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