Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Inflammation
Published in: Inflammation 1/2019

01-02-2019 | REVIEW

Common Pathogenesis of Acne Vulgaris and Atherosclerosis

Authors: Hao Jiang, Changyi Li

Published in: Inflammation | Issue 1/2019

Login to get access

Abstract

Foam cells are lipid-loaded macrophages and neutrophils that are generated from a massive uptake of oxidized lipid. Foam cells are a pathological hallmark of atherosclerosis, and have also been found in acne lesions. The same pathological changes determine the common pathogenesis. According to the pathological function of foam cells in these lesions, we put forward a viewpoint on the pathogenesis of acne and atherosclerotic plaques.
Appendix
Available only for authorised users
Literature
1.
Leyden, J.J. 1997. Therapy for acne vulgaris. The New England Journal of Medicine 336 (16): 1156–1162.CrossRefPubMed
2.
Crowther, M.A. 2005. Pathogenesis of atherosclerosis. Hematology. American Society of Hematology. Education Program: 436–441.
3.
Zouboulis, C.C., E. Jourdan, and M. Picardo. 2013. Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions. Journal of the European Academy of Dermatology & Venereology 28 (5): 527–532.CrossRef
4.
Sang, W.Y. 2010. The role of facial sebum secretion in acne pathogenesis: Facts and controversies. Clinics in Dermatology 28 (1): 8–11.CrossRef
5.
Jeremy, A.H., D.B. Holland, S.G. Roberts, K.F. Thomson, and W.J. Cunliffe. 2003. Inflammatory events are involved in acne lesion initiation. Journal of Investigative Dermatology 121 (1): 20–27.CrossRefPubMed
6.
Hansson, G.K., and A. Hermansson. 2011. The immune system in atherosclerosis. Nature Immunology 12 (3): 204–212.CrossRefPubMed
7.
Yuan, Y., P. Li, and J. Ye. 2012. Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis. Protein & Cell 3 (3): 173–181.CrossRef
8.
Pappas, A., S. Johnsen, J.C. Liu, and M. Eisinger. 2009. Sebum analysis of individuals with and without acne. Dermatoendocrinology 1 (3): 157–161.CrossRef
9.
Cheng, J.B., and D.W. Russell. 2004. Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. The Journal of Biological Chemistry 279 (36): 37798–37807.CrossRefPubMedPubMedCentral
10.
Picardo, Mauro, Monica Ottaviani, Emanuela Camera, and Arianna Mastrofrancesco. 2009. Sebaceous gland lipids. Dermatoendocrinology 1 (2): 68–71.CrossRef
11.
Kurokawa, I., F.W. Danby, Q. Ju, X. Wang, L.F. Xiang, L. Xia, W. Chen, I. Nagy, M. Picardo, D.H. Suh, R. Ganceviciene, S. Schagen, F. Tsatsou, and C.C. Zouboulis. 2009. New developments in our understanding of acne pathogenesis and treatment. Experimental Dermatology 18 (10): 821–832.CrossRefPubMed
12.
Tochio, T., H. Tanaka, S. Nakata, and H. Ikeno. 2009. Accumulation of lipid peroxide in the content of comedones may be involved in the progression of comedogenesis and inflammatory changes in comedones. Journal of Cosmetic Dermatology 8 (2): 152–158.CrossRefPubMed
13.
14.
Falk, Erling. 2006. Pathogenesis of atherosclerosis. Journal of the American College of Cardiology 47 (8 Suppl): C7–C12.
15.
Soehnlein, O. 2012. Multiple roles for neutrophils in atherosclerosis. Circulation Research 110 (6): 875–888.CrossRefPubMed
16.
Hayashi, F., T.K. Means, and A.D. Luster. 2003. Toll-like receptors stimulate human neutrophil function. Blood 102 (7): 2660–2669.CrossRef
17.
Sanjuan, M.A., C.P. Dillon, S.W. Tait, S. Moshiach, F. Dorsey, S. Connell, M. Komatsu, K. Tanaka, J.L. Cleveland, S. Withoff, and D.R. Green. 2007. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature 450 (7173): 1253–1257.CrossRefPubMed
18.
Monaco, C. 2012. The tolls and dangers of atherosclerotic disease. Current Pharmaceutical Biotechnology 13 (1): 77–87.CrossRefPubMed
19.
Bakry, O.A., R.M. Samaka, H. Sebika, and I. Seleit. 2014. Toll-like receptor 2 and P. acnes: do they trigger initial acne vulgaris lesions? Analytical and Quantitative Cytology and Histology 36 (2): 100–110.
20.
Säemann, M.D., M. Poglitsch, C. Kopecky, M. Haidinger, W.H. Hörl, and T. Weichhart. 2010. The versatility of HDL: a crucial anti-inflammatory regulator. European Journal of Clinical Investigation 40 (12): 1131–1143.CrossRefPubMed
21.
Lewis, G.F., and D.J. Rader. 2005. New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circulation Research 96 (12): 1221–1232.CrossRefPubMed
22.
Oyewole, A.O., and M.A. Birch-Machin. 2015. Sebum, inflammasomes and the skin: current concepts and future perspective. Experimental Dermatology 24 (9): 651–654.CrossRefPubMed
23.
Jiang, H., C.Y. Li, L. Zhou, B. Lu, Y. Lin, X. Huang, B. Wei, Q. Wang, L. Wang, and J. Lu. 2015. Acne patients frequently associated with abnormal plasma lipid profile. The Journal of Dermatology 42 (3): 296–299.CrossRefPubMed
24.
Okoro, E.O., N.G. Bulus, and C.C. Zouboulis. 2015. Study of facial sebum levels and follicular red fluorescence in patients with acne vulgaris in Nigeria. Dermatology 232 (2).
25.
Li, A.C., and C.K. Glass. 2002. The macrophage foam cell as a target for therapeutic intervention. Nature Medicine 8 (11): 1235–1242.CrossRefPubMed
26.
Röhm, Marc, Melissa J. Grimm, Anthony C. D'Auria, Nikolaos G. Almyroudis, Brahm H. Segal, and Constantin F. Urban. 2014. NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis. Infection & Immunity 82 (5): 1766–1777.CrossRef
27.
28.
Fernandez-Ruiz, I., P. Puchalska, C.A. Narasimhulu, B. Sengupta, and S. Parthasarathy. 2016. Differential lipid metabolism in monocytes and macrophages-influence of cholesterol loading. Journal of Lipid Research 57 (4): 574–586.CrossRefPubMedPubMedCentral
29.
Saran, M., I. Beck-Speier, B. Fellerhoff, and G. Bauer. 1999. Phagocytic killing of microorganisms by radical processes: consequences of the reaction of hydroxyl radicals with chloride yielding chlorine atoms. Free Radical Biology & Medicine 26 (3–4): 482–490.CrossRef
30.
Boer, J., and G.B. Jemec. 2016. Mechanical stress and the development of pseudo-comedones and tunnels in hidradenitis suppurativa/acne inversa. Experimental Dermatology 25 (5): 396–397.CrossRefPubMed
31.
Yang, J., and J.D. Adams Jr. 2004. Structure activity relationships for nicotinamide in the treatment of stroke. Letters in Drug Design & Discovery 1: 58–65.CrossRef
32.
Thompson, B.C., D. Surjana, G.M. Halliday, and D.L. Damian. 2014. Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in primary melanocytes. Experimental Dermatology 23 (7): 509–511.CrossRefPubMed
33.
Brüggemann, H., A. Henne, F. Hoster, H. Liesegang, A. Wiezer, A. Strittmatter, S. Hujer, P. Dürre, and G. Gottschalk. 2004. The complete genome sequence of Propionibacterium acnes, a commensal of human skin. Science 305 (5684): 671–673.CrossRefPubMed
34.
McKenney, J. 2004. New perspectives on the use of niacin in the treatment of lipid disorders. Archives of Internal Medicine 164 (7): 697–705.CrossRefPubMed
35.
Jiang, H., C. Li, B. Wei, Q. Wang, J. Zhong, and J. Lu. 2017. Serum homocysteine levels in acne patients. Journal of Cosmetic Dermatology.
36.
Duffy, D., and D.J. Rader. 2009. Update on strategies to increase HDL quantity and function. Nature Reviews. Cardiology 6 (7): 455–463.CrossRefPubMed
37.
Hao, Jiang, and Li Changyi. 2016. High dose niacin in the treatment of acne vulgaris: a pilot study. Chinese Journal of Aesthetic Medicine. 25 (12): 54–59.
Metadata
Title
Common Pathogenesis of Acne Vulgaris and Atherosclerosis
Authors
Hao Jiang
Changyi Li
Publication date
01-02-2019
Publisher
Springer US
Published in
Inflammation / Issue 1/2019
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-018-0863-y

Other articles of this Issue 1/2019

Inflammation 1/2019 Go to the issue

ORIGINAL ARTICLE

Electro-acupuncture Pretreatment at Zusanli (ST36) Acupoint Attenuates Lipopolysaccharide-Induced Inflammation in Rats by Inhibiting Ca2+ Influx Associated with Cannabinoid CB2 Receptors

ORIGINAL ARTICLE

Polyphyllin I Inhibits Propionibacterium acnes-Induced Inflammation In Vitro

ORIGINAL ARTICLE

Oridonin Ameliorates Lipopolysaccharide-Induced Endometritis in Mice via Inhibition of the TLR-4/NF-κBpathway

ORIGINAL ARTICLE

Application of Deacetylated Poly-N-Acetyl Glucosamine Nanoparticles for the Delivery of miR-126 for the Treatment of Cecal Ligation and Puncture-Induced Sepsis

ORIGINAL ARTICLE

MicroRNA-92a Drives Th1 Responses in the Experimental Autoimmune Encephalomyelitis

ORIGINAL ARTICLE

The Protective Effects and the Involved Mechanisms of Tanshinone IIA on Sepsis-Induced Brain Damage in Mice
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits