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Drugs & Aging
Published in: Drugs & Aging 2/2016

01-02-2016 | Letter to the Editor

Comment on: Pharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-Release Tablets to Elderly and Young Subjects

Author: Karel Allegaert

Published in: Drugs & Aging | Issue 2/2016

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Excerpt

Skinner-Robertson et al. recently reported in this journal on the enantiomer-specific pharmacokinetics of tramadol extended-release tablets in a cohort of 15 elderly subjects with mild renal insufficiency compared with 20 young adult subjects [1]. We value this compound-specific observation, but also would like to highlight its relevance as a model to assess the impact of organ-specific physiological decline in function on age-specific pharmacokinetics and stress the similarities with observations in young infants. …
Literature
1.
Skinner-Robertson S, Fradette C, Bouchard S, Mouksassi MS, Varin F. Pharmacokinetics of tramadol and O-desmethyltramadol enantiomers following administration of extended-release tablets to elderly and young subjects. Drugs Aging. 2015;32:1029–43.CrossRefPubMed
2.
Samant TS, Mangal N, Lukacova V, Schmidt S. Quantitative clinical pharmacology for size and age scaling in pediatric drug development: a systematic review. J Clin Pharmacol. 2015;55:1207–17.CrossRefPubMed
3.
Allegaert K, Rochette A, Veyckemans F. Developmental pharmacology of tramadol during infancy: ontogeny, pharmacogenetics and elimination clearance. Pediatr Anesth. 2011;21:266–73.CrossRef
4.
Allegaert K, Holford N, Anderson BJ, Holford S, Stuber F, Rochette A, Troconiz IF, Beier H, de Hoon JN, Pedersen RQS, Stamer U. Tramadol and O-desmethyl tramadol clearance maturation and disposition in humans: a pooled pharmacokinetic study. Clin Pharmacokinet. 2015;54:167–78.CrossRefPubMed
Metadata
Title
Comment on: Pharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-Release Tablets to Elderly and Young Subjects
Author
Karel Allegaert
Publication date
01-02-2016
Publisher
Springer International Publishing
Published in
Drugs & Aging / Issue 2/2016
Print ISSN: 1170-229X
Electronic ISSN: 1179-1969
DOI
https://doi.org/10.1007/s40266-015-0338-x

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