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Acta Neurochirurgica

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01-12-2009 | Case Report

Combined multiple surgical intervention and chemotherapy for multicentric WHO grade II glioma

A long-term follow-up study

Authors: Francesco Vergani, Marc Sanson, Hugues Duffau

Published in: Acta Neurochirurgica | Issue 12/2009

Abstract

Background

Multicentric WHO grade II gliomas constitute a rare entity. Their pathogenesis and treatment are still a matter of debate.

Objective

We present a 23 year-old female with two synchronous but separate WHO grade II oligodendrogliomas in the temporal and frontal lobes.

Clinical features

The two lesions showed independent evolution, requiring surgical treatment at different stages. For a recurrence of the disease at the frontal site, a temozolomide chemotherapy regimen was commenced with a favourable response. After 7 years follow-up, the patient is free of neurological symptoms and enjoys a normal life.

Conclusion

The problems concerning the pathophysiology, diagnosis and treatment of this condition are discussed. On the basis of our results, we suggest that an active therapeutic strategy, by combining multiple surgical procedures and complementary treatment, should be systematically considered in multicentric WHO grade II gliomas, as in similar unifocal neoplasms.

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Title: Combined multiple surgical intervention and chemotherapy for multicentric WHO grade II glioma
A long-term follow-up study
Authors: Francesco Vergani
Marc Sanson
Hugues Duffau
Publication date: 01-12-2009
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 12/2009
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-009-0306-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Combined multiple surgical intervention and chemotherapy for multicentric WHO grade II glioma

A long-term follow-up study

Abstract

Background

Objective

Clinical features

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objective

Clinical features

Conclusion

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