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Surgery Today
Published in: Surgery Today 3/2018

01-03-2018 | Original Article

Combined analysis of the pre- and postoperative neutrophil–lymphocyte ratio predicts the outcomes of patients with gastric cancer

Authors: Kozo Miyatani, Hiroaki Saito, Yusuke Kono, Yuki Murakami, Hirohiko Kuroda, Tomoyuki Matsunaga, Yoji Fukumoto, Tomohiro Osaki, Keigo Ashida, Yoshiyuki Fujiwara

Published in: Surgery Today | Issue 3/2018

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Abstract

Purpose

The neutrophil–lymphocyte ratio (NLR) is a biochemical marker of the systemic inflammatory response and has been associated with prognosis for various types of cancer. This retrospective study investigates the relationship between the pre- and postoperative NLR and the prognosis of gastric cancer patients.

Methods

The subjects were 280 patients who underwent curative surgery for histopathologically diagnosed gastric adenocarcinoma.

Results

The preoperative NLR was significantly correlated with tumor size, tumor depth, lymphatic invasion, venous invasion, and disease stage. In contrast, there was no correlation between the postoperative NLR and the various clinicopathological variables. Prognosis was significantly worse for patients with a high preoperative NLR than for those with a low preoperative NLR. Prognosis was also significantly worse for patients with a high postoperative NLR than for those with a low postoperative NLR. Furthermore, the prognosis was worse for gastric cancer patients whose pre- and postoperative NLRs were both high. Multivariate analysis indicated that a high pre- and postoperative NLR was an independent prognostic indicator.

Conclusions

The combination of pre- and postoperative NLRs appears to be useful for predicting the prognosis of gastric cancer patients.
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Metadata
Title
Combined analysis of the pre- and postoperative neutrophil–lymphocyte ratio predicts the outcomes of patients with gastric cancer
Authors
Kozo Miyatani
Hiroaki Saito
Yusuke Kono
Yuki Murakami
Hirohiko Kuroda
Tomoyuki Matsunaga
Yoji Fukumoto
Tomohiro Osaki
Keigo Ashida
Yoshiyuki Fujiwara
Publication date
01-03-2018
Publisher
Springer Singapore
Published in
Surgery Today / Issue 3/2018
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-017-1587-6

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