Published in:
01-09-2012 | Brief Communication
Colorectal Liver Metastases with Extrahepatic Disease—A New Criteria for Oncologic Resection?
Published in: Journal of Gastrointestinal Cancer | Issue 3/2012
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Background
Emerging data suggest that in the current era of modern systemic therapies, resection of colorectal liver metastases with concomitant extrahepatic disease may be a curative option in selected patients.
Methods
A commentary of several key recent papers including an international multi-institutional registry study may provide directions in the future management of this disease entity.
Results
The premise of selecting patients for a surgical approach to resect colorectal liver metastases and concomitant extrahepatic disease should be individualized. Incorporation of key prognostic factors that include the site of extrahepatic disease, the ability to undertake a complete resection, disease responding to chemotherapy, and an assessment of tumor biology through examining an individual’s disease history may guide the selection of suitable patients for this therapeutic pursuit. A 5-year survival of 30% may be realized in well-selected patients.
Conclusion
Concomitant extrahepatic disease in patients with colorectal liver metastases should not be a contraindication to resection of colorectal cancer metastases.