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BMC Gastroenterology
Published in: BMC Gastroenterology 1/2019

Open Access 01-12-2019 | Colorectal Cancer | Research article

Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer

Authors: Jiang Liu, Li Tang, Jinhua Yi, Guimei Li, Youwang Lu, Yu Xu, Shuhua Zhao, Rui Mao, Xiaolu Li, Li Ren, Kunhua Wang

Published in: BMC Gastroenterology | Issue 1/2019

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Abstract

Background

Molecular characteristics of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been well documented in Western, but not in Chinese, populations.

Methods

We investigated the incidence of CIMP, BRAF/KRAS mutation, and microsatellite instability (MSI) in a Chinese population with CRC (n = 401) and analysed associations between CIMP status and clinicopathological and molecular features.

Results

A total of 41 cases, 310 cases, and 40 cases were classified as CIMP-high, CIMP-low, and CIMP-negative, respectively. We detected a significantly low incidence of BRAF mutation in adenomas (2%) and CRC (0.7%), and a relatively low incidence of KRAS mutation (24.9%) compared with that in other populations. We also detected a relatively low incidence of CIMP-high (10.2%), which was significantly associated with younger age (≤49 years of age), female sex, and proximal tumour location.

Conclusions

This study revealed unique characteristics of CIMP in a Chinese population with colorectal cancer. Developing specific CIMP markers based on unique populations or ethnic groups will further help to fully elucidate CIMP pathogenesis.
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Metadata
Title
Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer
Authors
Jiang Liu
Li Tang
Jinhua Yi
Guimei Li
Youwang Lu
Yu Xu
Shuhua Zhao
Rui Mao
Xiaolu Li
Li Ren
Kunhua Wang
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2019
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/s12876-019-1086-x

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