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Surgery Today
Published in: Surgery Today 1/2021

01-01-2021 | Colorectal Cancer | Original Article

The Controlling Nutritional Status (CONUT) Score as a prognostic factor for obstructive colorectal cancer patients received stenting as a bridge to curative surgery

Authors: Ryuichiro Sato, Masaya Oikawa, Tetsuya Kakita, Takaho Okada, Tomoya Abe, Takashi Yazawa, Haruyuki Tsuchiya, Naoya Akazawa, Masaki Sato, Tetsuya Ohira, Yoshihiro Harada, Haruka Okano, Kei Ito, Takashi Tsuchiya

Published in: Surgery Today | Issue 1/2021

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Abstract

Purpose

The Controlling Nutritional Status (CONUT) Score, originally developed as a nutritional screening tool, is a cumulative score calculated from the serum albumin level, total cholesterol level, and total lymphocyte count. Previous studies have demonstrated that the score has significant prognostic value in various malignancies. We investigated the relationship between the CONUT score and long-term survival in obstructive colorectal cancer (OCRC) patients who underwent self-expandable metallic colonic stent placement and subsequently received curative surgery.

Methods

We retrospectively analyzed 57 pathological stage II and III OCRC patients between 2013 and 2019. The associations between the preoperative CONUT score and clinicopathological factors and patient survival were evaluated.

Results

A receiver operating characteristic curve analysis revealed that the optimal cut-off value for the CONUT score was 7. A CONUT score of ≥ 7 was significantly associated with elevated CA19-9 level (p = 0.03). Multivariate analyses revealed that a CONUT score of ≥ 7 was independently associated with cancer-specific survival (hazard ratio [HR] = 10.2, 95% confidence interval [CI] 1.2–85.9, p = 0.03) and disease-free survival (HR = 7.1, 95% CI 2.3–21.7, p = 0.0006).

Conclusion

The results demonstrated that the CONUT score was a potent prognostic indicator. Evaluating the CONUT score might result in more precise patient assessment and tailored treatment.
Appendix
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Metadata
Title
The Controlling Nutritional Status (CONUT) Score as a prognostic factor for obstructive colorectal cancer patients received stenting as a bridge to curative surgery
Authors
Ryuichiro Sato
Masaya Oikawa
Tetsuya Kakita
Takaho Okada
Tomoya Abe
Takashi Yazawa
Haruyuki Tsuchiya
Naoya Akazawa
Masaki Sato
Tetsuya Ohira
Yoshihiro Harada
Haruka Okano
Kei Ito
Takashi Tsuchiya
Publication date
01-01-2021
Publisher
Springer Singapore
Published in
Surgery Today / Issue 1/2021
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-020-02066-8

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