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Surgery Today
Published in: Surgery Today 6/2017

01-06-2017 | Original Article

The impact of the preoperative peripheral lymphocyte count and lymphocyte percentage in patients with colorectal cancer

Authors: Yasuhito Iseki, Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsuro Tamura, Go Ohira, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma, Kosei Hirakawa, Masaichi Ohira

Published in: Surgery Today | Issue 6/2017

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Abstract

Purpose

We evaluated the prognostic significance of the peripheral lymphocyte count and lymphocyte percentage, which reflect the preoperative immune status, in patients with colorectal cancer (CRC) and then compared their accuracy as predictors of the survival.

Methods

We retrospectively reviewed a database of 362 patients. We classified the patients into high lymphocyte count and low lymphocyte count groups. We also classified the patients into high lymphocyte percentage and low lymphocyte percentage groups.

Results

The 5-year relapse-free survival (RFS) rate in the high lymphocyte count group tended to be higher than that in the low lymphocyte count group. The 5-year overall survival (OS) rate in the high lymphocyte count group was significantly higher than that in the low lymphocyte count group. In contrast, the 5-year RFS and OS rates in the high lymphocyte percentage group were both significantly higher than those in the low lymphocyte percentage group. A multivariate analysis showed that the lymphocyte percentage was independently associated with the OS.

Conclusions

These findings suggest that the lymphocyte percentage is a good predictor of the OS and may be a stronger predictor of survival than the lymphocyte count in CRC patients.
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Metadata
Title
The impact of the preoperative peripheral lymphocyte count and lymphocyte percentage in patients with colorectal cancer
Authors
Yasuhito Iseki
Masatsune Shibutani
Kiyoshi Maeda
Hisashi Nagahara
Tatsuro Tamura
Go Ohira
Sadaaki Yamazoe
Kenjiro Kimura
Takahiro Toyokawa
Ryosuke Amano
Hiroaki Tanaka
Kazuya Muguruma
Kosei Hirakawa
Masaichi Ohira
Publication date
01-06-2017
Publisher
Springer Japan
Published in
Surgery Today / Issue 6/2017
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-016-1433-2

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