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Journal of Experimental & Clinical Cancer Research
Published in: Journal of Experimental & Clinical Cancer Research 1/2021

Open Access 01-12-2021 | Colorectal Cancer | Review

Patient-derived tumor models: a more suitable tool for pre-clinical studies in colorectal cancer

Authors: Giulia Rizzo, Andrea Bertotti, Simonetta Maria Leto, Stefania Vetrano

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2021

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Abstract

Colorectal cancer (CRC), despite the advances in screening and surveillance, remains the second most common cause of cancer death worldwide. The biological inadequacy of pre-clinical models to fully recapitulate the multifactorial etiology and the complexity of tumor microenvironment and human CRC’s genetic heterogeneity has limited cancer treatment development. This has led to the development of Patient-derived models able to phenocopy as much as possible the original inter- and intra-tumor heterogeneity of CRC, reflecting the tumor microenvironment’s cellular interactions. Implantation of patient tissue into immunodeficient mice hosts and the culture of tumor organoids have allowed advances in cancer biology and metastasis. This review highlights the advantages and limits of Patient-derived models as innovative and valuable pre-clinical tools to study progression and metastasis of CRC, develop novel therapeutic strategies by creating a drug screening platform, and predict the efficacy of clinical response to therapy.
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Metadata
Title
Patient-derived tumor models: a more suitable tool for pre-clinical studies in colorectal cancer
Authors
Giulia Rizzo
Andrea Bertotti
Simonetta Maria Leto
Stefania Vetrano
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2021
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/s13046-021-01970-2

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