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Published in:

01-04-2018 | Nephrology - Review

Collectins in urinary tract and kidney diseases

Authors: Yongfang Qin, Jingjing Liu, Jiao Liu, Fengqi Hu

Published in: International Urology and Nephrology | Issue 4/2018

Abstract

The innate immune system serves as the frontline defense against invading pathogens and initiates an inflammatory response to microorganisms. Collectins are C-type lectins that are structurally characterized by a collagen-like sequence and a carbohydrate recognition domain. Moreover, they are widely expressed throughout the body and are involved in the innate immunity against a variety of pathogens, regulating inflammation, and protecting the lungs from pathogens. Recently, two classical collectins, surfactant protein A (SP-A) and surfactant protein D (SP-D), as well as novel collectin 11, were found present in urinary tract tissues. They are increasingly recognized as key players in activating the humoral arm of innate immunity and host defense in urinary tract and kidney diseases, although their biological features, functions, and mechanisms in this regard remain largely unclear. In this review, we aim to integrate results reported by ourselves and others to summarize and gain a better understanding of the functions of collectins (SP-A, SP-D, and collectin 11) in urinary tract and kidney diseases.

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Title: Collectins in urinary tract and kidney diseases
Authors: Yongfang Qin
Jingjing Liu
Jiao Liu
Fengqi Hu
Publication date: 01-04-2018
Publisher: Springer Netherlands
Published in: International Urology and Nephrology / Issue 4/2018
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-017-1728-2

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