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International Journal of Colorectal Disease

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01-02-2020 | Colectomy | Original Article

The effect of preemptive use of pregabalin on postoperative morphine consumption and analgesia levels after laparoscopic colorectal surgery: a controlled randomized trial

Authors: Ioannis Baloyiannis, Eleni Theodorou, Chamaidi Sarakatsianou, Stavroula Georgopoulou, Konstantinos Perivoliotis, George Tzovaras

Published in: International Journal of Colorectal Disease | Issue 2/2020

Abstract

Purpose

In order to reduce postoperative opioid administration and pain levels in patients submitted to laparoscopic colectomy, we assessed the efficacy of preemptive use of pregabalin (PG), as part of a multimodal analgesia scheme, in a randomized controlled trial setting.

Methods

Overall, fifty adult patients scheduled for elective laparoscopic colectomy were included and randomized in our trial. In the experimental group, 23 patients received preoperatively 2 doses of 150 mg PG per os, whereas the control group consisted of 27 cases, where a matching to PG placebo was administered at the same scheme. The two groups had identical analgesia and anesthesia regimens otherwise. Our study endpoints included postoperative morphine consumption, postoperative pain, and complication rates.

Results

Patients in the PG group displayed a significantly reduced morphine consumption at 8 h, 24 h, and 48 h postoperatively. The two groups were comparable in terms of postoperative pain (rest and movement assessment) and side effects.

Conclusions

The preoperative addition of PG resulted in a significant reduction of the postoperative opioid consumption in patients undergoing laparoscopic colectomy. However, an association with the postoperative pain scores was not identified.

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Title: The effect of preemptive use of pregabalin on postoperative morphine consumption and analgesia levels after laparoscopic colorectal surgery: a controlled randomized trial
Authors: Ioannis Baloyiannis
Eleni Theodorou
Chamaidi Sarakatsianou
Stavroula Georgopoulou
Konstantinos Perivoliotis
George Tzovaras
Publication date: 01-02-2020
Publisher: Springer Berlin Heidelberg
Keywords: Colectomy
Colectomy
Opioids
Opioids
Morphine
Pregabalin
Published in: International Journal of Colorectal Disease / Issue 2/2020
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-019-03471-3

2024 ASCO Annual Meeting

Springer Medicine

The effect of preemptive use of pregabalin on postoperative morphine consumption and analgesia levels after laparoscopic colorectal surgery: a controlled randomized trial

Abstract

Purpose

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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