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01-09-2009 | Original Article

COL3A1 2209G>A is a predictor of pelvic organ prolapse

Authors: Kirsten B. Kluivers, Jeroen R. Dijkstra, Jan C. M. Hendriks, Sabrina L. Lince, Mark E. Vierhout, Léon C. L. van Kempen

Published in: International Urogynecology Journal | Issue 9/2009

Abstract

Introduction and hypothesis

A familial tendency has been demonstrated in the etiology of pelvic organ prolapse (POP), but the specific genetic defects have not been identified. Type III collagen is an important factor in the repair of connective tissue, and gene polymorphisms may impair the tensile strength. We hypothesized that polymorphisms in the alpha I chain of the type III collagen protein-encoding gene (COL3A1) pose women at risk for POP.

Methods

In this case–control study, the prevalence of type III collagen polymorphisms was compared in women with and without signs and symptoms of POP.

Results

Two hundred and two POP patients and 102 normal parous controls were included. A homozygous single-nucleotide substitution in the coding region of type III collagen (COL3A1 2209G>A, rs1800255) was identified in 27 (13%) POP patients and three (3%) controls (odds ratio, 5.0; 95% confidence interval, 1.4–17.1).

Conclusions

The probability of POP was higher in women with COL3A1 2209G>A. This polymorphism showed to be a relevant risk factor for POP.

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Title: COL3A1 2209G>A is a predictor of pelvic organ prolapse
Authors: Kirsten B. Kluivers
Jeroen R. Dijkstra
Jan C. M. Hendriks
Sabrina L. Lince
Mark E. Vierhout
Léon C. L. van Kempen
Publication date: 01-09-2009
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 9/2009
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-009-0913-y

At a glance: The STEP trials

Springer Medicine

COL3A1 2209G>A is a predictor of pelvic organ prolapse

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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