Skip to main content
Top
Published in: BMC Geriatrics 1/2012

Open Access 01-12-2012 | Research article

Cognitive impairment is undetected in medical inpatients: a study of mortality and recognition amongst healthcare professionals

Authors: Gustav Torisson, Lennart Minthon, Lars Stavenow, Elisabet Londos

Published in: BMC Geriatrics | Issue 1/2012

Login to get access

Abstract

Background

Detecting cognitive impairment in medical inpatients is important due to its association with adverse outcomes. Our aim was to study recognition of cognitive impairment and its association with mortality.

Methods

200 inpatients aged over 60 years were recruited at the Department of General Internal Medicine at University Hospital MAS in Malmö, Sweden. The MMSE (Mini-Mental State Examination) and the CDT (Clock-Drawing Test) were performed and related to recognition rates by patients, staff physicians, nurses and informants. The impact of abnormal cognitive test results on mortality was studied using a multivariable Cox proportional hazards regression.

Results

55 patients (28%) had no cognitive impairment while 68 patients (34%) had 1 abnormal test result (on MMSE or CDT) and 77 patients (39%) had 2 abnormal test results. Recognition by healthcare professionals was 12% in the group with 1 abnormal test and 44-64% in the group with 2 abnormal test results. In our model, cognitive impairment predicted 12-month mortality with a hazard ratio (95% CI) of 2.86 (1.28-6.39) for the group with 1 abnormal cognitive test and 3.39 (1.54-7.45) for the group with 2 abnormal test results.

Conclusions

Cognitive impairment is frequent in medical inpatients and associated with increased mortality. Recognition rates of cognitive impairment need to be improved in hospitals.
Appendix
Available only for authorised users
Literature
1.
go back to reference Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, et al: Global prevalence of dementia: a Delphi consensus study. Lancet. 2005, 366: 2112-2117.CrossRefPubMedPubMedCentral Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, et al: Global prevalence of dementia: a Delphi consensus study. Lancet. 2005, 366: 2112-2117.CrossRefPubMedPubMedCentral
2.
go back to reference Freedberg DE, Dave J, Kurth T, Gaziano JM, Bludau JH: Cognitive impairment over the age of 85: hospitalization and mortality. Arch Gerontol Geriatr. 2008, 46: 137-145. 10.1016/j.archger.2007.03.006.CrossRefPubMed Freedberg DE, Dave J, Kurth T, Gaziano JM, Bludau JH: Cognitive impairment over the age of 85: hospitalization and mortality. Arch Gerontol Geriatr. 2008, 46: 137-145. 10.1016/j.archger.2007.03.006.CrossRefPubMed
3.
go back to reference Inouye SK, Peduzzi PN, Robison JT, Hughes JS, Horwitz RI, Concato J: Importance of functional measures in predicting mortality among older hospitalized patients. JAMA. 1998, 279: 1187-1193. 10.1001/jama.279.15.1187.CrossRefPubMed Inouye SK, Peduzzi PN, Robison JT, Hughes JS, Horwitz RI, Concato J: Importance of functional measures in predicting mortality among older hospitalized patients. JAMA. 1998, 279: 1187-1193. 10.1001/jama.279.15.1187.CrossRefPubMed
4.
go back to reference Zuccala G, Pedone C, Cesari M, Onder G, Pahor M, Marzetti E, Lo Monaco MR, Cocchi A, Carbonin P, Bernabei R: The effects of cognitive impairment on mortality among hospitalized patients with heart failure. The Am J Med. 2003, 115: 97-103.CrossRefPubMed Zuccala G, Pedone C, Cesari M, Onder G, Pahor M, Marzetti E, Lo Monaco MR, Cocchi A, Carbonin P, Bernabei R: The effects of cognitive impairment on mortality among hospitalized patients with heart failure. The Am J Med. 2003, 115: 97-103.CrossRefPubMed
5.
go back to reference Fu C, Chute DJ, Farag ES, Garakian J, Cummings JL, Vinters HV: Comorbidity in dementia: an autopsy study. Arch Pathol Lab Med. 2004, 128: 32-38.PubMed Fu C, Chute DJ, Farag ES, Garakian J, Cummings JL, Vinters HV: Comorbidity in dementia: an autopsy study. Arch Pathol Lab Med. 2004, 128: 32-38.PubMed
6.
go back to reference Lopponen MK, Isoaho RE, Raiha IJ, Vahlberg TJ, Loikas SM, Takala TI, Puolijoki H, Irjala KM, Kivela SL: Undiagnosed diseases in patients with dementia–a potential target group for intervention. Dement Geriatr Cogn Disord. 2004, 18: 321-329. 10.1159/000080126.CrossRefPubMed Lopponen MK, Isoaho RE, Raiha IJ, Vahlberg TJ, Loikas SM, Takala TI, Puolijoki H, Irjala KM, Kivela SL: Undiagnosed diseases in patients with dementia–a potential target group for intervention. Dement Geriatr Cogn Disord. 2004, 18: 321-329. 10.1159/000080126.CrossRefPubMed
7.
go back to reference Raymont V, Bingley W, Buchanan A, David AS, Hayward P, Wessely S, Hotopf M: Prevalence of mental incapacity in medical inpatients and associated risk factors: cross-sectional study. Lancet. 2004, 364: 1421-1427. 10.1016/S0140-6736(04)17224-3.CrossRefPubMed Raymont V, Bingley W, Buchanan A, David AS, Hayward P, Wessely S, Hotopf M: Prevalence of mental incapacity in medical inpatients and associated risk factors: cross-sectional study. Lancet. 2004, 364: 1421-1427. 10.1016/S0140-6736(04)17224-3.CrossRefPubMed
8.
go back to reference Tierney MC, Charles J, Naglie G, Jaglal S, Kiss A, Fisher RH: Risk factors for harm in cognitively impaired seniors who live alone: a prospective study. J Am Geriatr Soc. 2004, 52: 1435-1441. 10.1111/j.0002-8614.2004.52404.x.CrossRefPubMed Tierney MC, Charles J, Naglie G, Jaglal S, Kiss A, Fisher RH: Risk factors for harm in cognitively impaired seniors who live alone: a prospective study. J Am Geriatr Soc. 2004, 52: 1435-1441. 10.1111/j.0002-8614.2004.52404.x.CrossRefPubMed
9.
go back to reference Han JH, Bryce SN, Ely EW, Kripalani S, Morandi A, Shintani A, Jackson JC, Storrow AB, Dittus RS, Schnelle J: The effect of cognitive impairment on the accuracy of the presenting complaint and discharge instruction comprehension in older emergency department patients. Ann Emerg Med. 2011, 57: 662-671. 10.1016/j.annemergmed.2010.12.002. e662CrossRefPubMedPubMedCentral Han JH, Bryce SN, Ely EW, Kripalani S, Morandi A, Shintani A, Jackson JC, Storrow AB, Dittus RS, Schnelle J: The effect of cognitive impairment on the accuracy of the presenting complaint and discharge instruction comprehension in older emergency department patients. Ann Emerg Med. 2011, 57: 662-671. 10.1016/j.annemergmed.2010.12.002. e662CrossRefPubMedPubMedCentral
10.
go back to reference Bowler C, Boyle A, Branford M, Cooper SA, Harper R, Lindesay J: Detection of psychiatric disorders in elderly medical inpatients. Age Ageing. 1994, 23: 307-311. 10.1093/ageing/23.4.307.CrossRefPubMed Bowler C, Boyle A, Branford M, Cooper SA, Harper R, Lindesay J: Detection of psychiatric disorders in elderly medical inpatients. Age Ageing. 1994, 23: 307-311. 10.1093/ageing/23.4.307.CrossRefPubMed
11.
go back to reference Douzenis A, Michopoulos I, Gournellis R, Christodoulou C, Kalkavoura C, Michalopoulou PG, Fineti K, Patapis P, Protopapas K, Lykouras L: Cognitive decline and dementia in elderly medical inpatients remain underestimated and underdiagnosed in a recently established university general hospital in Greece. Arch Gerontol Geriatr. 2010, 50: 147-150. 10.1016/j.archger.2009.03.001.CrossRefPubMed Douzenis A, Michopoulos I, Gournellis R, Christodoulou C, Kalkavoura C, Michalopoulou PG, Fineti K, Patapis P, Protopapas K, Lykouras L: Cognitive decline and dementia in elderly medical inpatients remain underestimated and underdiagnosed in a recently established university general hospital in Greece. Arch Gerontol Geriatr. 2010, 50: 147-150. 10.1016/j.archger.2009.03.001.CrossRefPubMed
12.
go back to reference Harwood DM, Hope T, Jacoby R: Cognitive impairment in medical inpatients. II: Do physicians miss cognitive impairment?. Age Ageing. 1997, 26: 37-39.CrossRefPubMed Harwood DM, Hope T, Jacoby R: Cognitive impairment in medical inpatients. II: Do physicians miss cognitive impairment?. Age Ageing. 1997, 26: 37-39.CrossRefPubMed
13.
go back to reference Inouye SK, Foreman MD, Mion LC, Katz KH, Cooney LM: Nurses' recognition of delirium and its symptoms: comparison of nurse and researcher ratings. Arch Intern Med. 2001, 161: 2467-2473. 10.1001/archinte.161.20.2467.CrossRefPubMed Inouye SK, Foreman MD, Mion LC, Katz KH, Cooney LM: Nurses' recognition of delirium and its symptoms: comparison of nurse and researcher ratings. Arch Intern Med. 2001, 161: 2467-2473. 10.1001/archinte.161.20.2467.CrossRefPubMed
14.
go back to reference Souder E, O'Sullivan PS: Nursing documentation versus standardized assessment of cognitive status in hospitalized medical patients. Applied nursing research : ANR. 2000, 13: 29-36. 10.1016/S0897-1897(00)80016-6.CrossRefPubMed Souder E, O'Sullivan PS: Nursing documentation versus standardized assessment of cognitive status in hospitalized medical patients. Applied nursing research : ANR. 2000, 13: 29-36. 10.1016/S0897-1897(00)80016-6.CrossRefPubMed
15.
go back to reference Brayne C, Fox C, Boustani M: Dementia screening in primary care: is it time?. JAMA. 2007, 298: 2409-2411. 10.1001/jama.298.20.2409.CrossRefPubMed Brayne C, Fox C, Boustani M: Dementia screening in primary care: is it time?. JAMA. 2007, 298: 2409-2411. 10.1001/jama.298.20.2409.CrossRefPubMed
16.
go back to reference Chodosh J, Petitti DB, Elliott M, Hays RD, Crooks VC, Reuben DB, Galen Buckwalter J, Wenger N: Physician recognition of cognitive impairment: evaluating the need for improvement. J Am Geriatrics Soc. 2004, 52: 1051-1059. 10.1111/j.1532-5415.2004.52301.x.CrossRef Chodosh J, Petitti DB, Elliott M, Hays RD, Crooks VC, Reuben DB, Galen Buckwalter J, Wenger N: Physician recognition of cognitive impairment: evaluating the need for improvement. J Am Geriatrics Soc. 2004, 52: 1051-1059. 10.1111/j.1532-5415.2004.52301.x.CrossRef
17.
go back to reference Olafsdottir M, Skoog I, Marcusson J: Detection of dementia in primary care: the Linkoping study. Dement Geriatr Cogn Disord. 2000, 11: 223-229. 10.1159/000017241.CrossRefPubMed Olafsdottir M, Skoog I, Marcusson J: Detection of dementia in primary care: the Linkoping study. Dement Geriatr Cogn Disord. 2000, 11: 223-229. 10.1159/000017241.CrossRefPubMed
18.
go back to reference Lopponen M, Raiha I, Isoaho R, Vahlberg T, Kivela SL: Diagnosing cognitive impairment and dementia in primary health care – a more active approach is needed. Age Ageing. 2003, 32: 606-612. 10.1093/ageing/afg097.CrossRefPubMed Lopponen M, Raiha I, Isoaho R, Vahlberg T, Kivela SL: Diagnosing cognitive impairment and dementia in primary health care – a more active approach is needed. Age Ageing. 2003, 32: 606-612. 10.1093/ageing/afg097.CrossRefPubMed
19.
go back to reference Sternberg SA, Wolfson C, Baumgarten M: Undetected dementia in community-dwelling older people: the Canadian Study of Health and Aging. J Am Geriatr Soc. 2000, 48: 1430-1434.CrossRefPubMed Sternberg SA, Wolfson C, Baumgarten M: Undetected dementia in community-dwelling older people: the Canadian Study of Health and Aging. J Am Geriatr Soc. 2000, 48: 1430-1434.CrossRefPubMed
20.
go back to reference Abdulrab K, Heun R: Subjective memory impairment a review of its definitions indicates the need for a comprehensive set of standardised and validated criteria. European psychiatry : the J Association of European Psychiatrists. 2008, 23: 321-330. 10.1016/j.eurpsy.2008.02.004.CrossRef Abdulrab K, Heun R: Subjective memory impairment a review of its definitions indicates the need for a comprehensive set of standardised and validated criteria. European psychiatry : the J Association of European Psychiatrists. 2008, 23: 321-330. 10.1016/j.eurpsy.2008.02.004.CrossRef
21.
go back to reference Amariglio RE, Townsend MK, Grodstein F, Sperling RA, Rentz DM: Specific subjective memory complaints in older persons may indicate poor cognitive function. J Am Geriatr Soc. 2011, 59: 1612-1617. 10.1111/j.1532-5415.2011.03543.x.CrossRefPubMedPubMedCentral Amariglio RE, Townsend MK, Grodstein F, Sperling RA, Rentz DM: Specific subjective memory complaints in older persons may indicate poor cognitive function. J Am Geriatr Soc. 2011, 59: 1612-1617. 10.1111/j.1532-5415.2011.03543.x.CrossRefPubMedPubMedCentral
22.
go back to reference Potter J, George J: The prevention, diagnosis and management of delirium in older people: concise guidelines. Clin Med. 2006, 6: 303-308.CrossRef Potter J, George J: The prevention, diagnosis and management of delirium in older people: concise guidelines. Clin Med. 2006, 6: 303-308.CrossRef
23.
go back to reference Downton JH: Falls in the Elderly. 1993, Hodder Arnold, London Downton JH: Falls in the Elderly. 1993, Hodder Arnold, London
24.
go back to reference Ek AC, Unosson M, Bjurulf P: The modified Norton scale and the nutritional state. Scand J Caring Sci. 1989, 3: 183-187.CrossRefPubMed Ek AC, Unosson M, Bjurulf P: The modified Norton scale and the nutritional state. Scand J Caring Sci. 1989, 3: 183-187.CrossRefPubMed
25.
go back to reference Charlson M, Szatrowski TP, Peterson J, Gold J: Validation of a combined comorbidity index. J Clin Epidemiol. 1994, 47: 1245-1251. 10.1016/0895-4356(94)90129-5.CrossRefPubMed Charlson M, Szatrowski TP, Peterson J, Gold J: Validation of a combined comorbidity index. J Clin Epidemiol. 1994, 47: 1245-1251. 10.1016/0895-4356(94)90129-5.CrossRefPubMed
26.
go back to reference Folstein MF, Folstein SE, McHugh PR: "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975, 12: 189-198. 10.1016/0022-3956(75)90026-6.CrossRefPubMed Folstein MF, Folstein SE, McHugh PR: "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975, 12: 189-198. 10.1016/0022-3956(75)90026-6.CrossRefPubMed
27.
go back to reference Shulman KI: Clock-drawing: is it the ideal cognitive screening test?. Int J Geriatr Psychiatry. 2000, 15: 548-561. 10.1002/1099-1166(200006)15:6<548::AID-GPS242>3.0.CO;2-U.CrossRefPubMed Shulman KI: Clock-drawing: is it the ideal cognitive screening test?. Int J Geriatr Psychiatry. 2000, 15: 548-561. 10.1002/1099-1166(200006)15:6<548::AID-GPS242>3.0.CO;2-U.CrossRefPubMed
28.
go back to reference Manos PJ: The utility of the ten-point clock test as a screen for cognitive impairment in general hospital patients. Gen Hosp Psychiatry. 1997, 19: 439-444. 10.1016/S0163-8343(97)00072-8.CrossRefPubMed Manos PJ: The utility of the ten-point clock test as a screen for cognitive impairment in general hospital patients. Gen Hosp Psychiatry. 1997, 19: 439-444. 10.1016/S0163-8343(97)00072-8.CrossRefPubMed
29.
go back to reference Logsdon RG, Gibbons LE, McCurry SM, Teri L: Assessing quality of life in older adults with cognitive impairment. Psychosom Med. 2002, 64: 510-519.CrossRefPubMed Logsdon RG, Gibbons LE, McCurry SM, Teri L: Assessing quality of life in older adults with cognitive impairment. Psychosom Med. 2002, 64: 510-519.CrossRefPubMed
Metadata
Title
Cognitive impairment is undetected in medical inpatients: a study of mortality and recognition amongst healthcare professionals
Authors
Gustav Torisson
Lennart Minthon
Lars Stavenow
Elisabet Londos
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2012
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/1471-2318-12-47

Other articles of this Issue 1/2012

BMC Geriatrics 1/2012 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.