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The Journal of Headache and Pain

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Open Access 01-12-2024 | Cluster Headache | Methodology

Commentary on 2022 guidelines on clinical trial design in cluster headache and further suggestions

Authors: Ioana Medrea, Stewart J. Tepper, Donliang Wang, Paul G. Mathew, Mark Burish

Published in: The Journal of Headache and Pain | Issue 1/2024

Abstract

Background

New guidelines for cluster headache clinical trials were recently published. We welcome these new guidelines and raise additional considerations in trial methodologies.

Main body

We present non-inferiority trials to overcome ethical issues with placebo use, and additionally discuss issues with trial recruitment.

Conclusions

We highlight some possible issues and solutions to be considered with the recently published cluster headache trial guidelines.

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Title: Commentary on 2022 guidelines on clinical trial design in cluster headache and further suggestions
Authors: Ioana Medrea
Stewart J. Tepper
Donliang Wang
Paul G. Mathew
Mark Burish
Publication date: 01-12-2024
Publisher: Springer Milan
Keywords: Cluster Headache
Headache
Sumatriptan
Zolmitriptan
Published in: The Journal of Headache and Pain / Issue 1/2024
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-024-01732-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Commentary on 2022 guidelines on clinical trial design in cluster headache and further suggestions

Abstract

Background

Main body

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Main body

Conclusions

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