Determination of the prebiotic activity of wheat arabinogalactan peptide (AGP) using batch culture fermentation

go back to reference JMares D, Stone B (1973) Studies on wheat endosperm I. Chemical composition and ultrastructure of the cell walls. Aust J Biol Sci 26:793. https://doi.org/10.1071/BI9730793 CrossRef JMares D, Stone B (1973) Studies on wheat endosperm I. Chemical composition and ultrastructure of the cell walls. Aust J Biol Sci 26:793. https://​doi.​org/​10.​1071/​BI9730793 CrossRef

go back to reference Huynh B-L, Palmer L, Mather DE, Wallwork H, Graham RD, Welch RM, Stangoulis JCR (2008) Genotypic variation in wheat grain fructan content revealed by a simplified HPLC method. J Cereal Sci 48:369–378. https://doi.org/10.1016/j.jcs.2007.10.004 CrossRef Huynh B-L, Palmer L, Mather DE, Wallwork H, Graham RD, Welch RM, Stangoulis JCR (2008) Genotypic variation in wheat grain fructan content revealed by a simplified HPLC method. J Cereal Sci 48:369–378. https://​doi.​org/​10.​1016/​j.​jcs.​2007.​10.​004 CrossRef

go back to reference Loosveld A-MA, Grobet PJ, Delcour JA (1997) Contents and structural features of water-extractable arabinogalactan in wheat flour fractions. J Agric Food Chem 45:1998–2002. https://doi.org/10.1021/jf960901k CrossRef Loosveld A-MA, Grobet PJ, Delcour JA (1997) Contents and structural features of water-extractable arabinogalactan in wheat flour fractions. J Agric Food Chem 45:1998–2002. https://​doi.​org/​10.​1021/​jf960901k CrossRef

go back to reference Loosveld A, Maes C, van Casteren WHM, Schols HA, Grobet PJ, Delcour JA (1998) Structural Variation and levels of water-extractable arabinogalactan-peptide in European wheat flours. Cereal Chem J 75:815–819. https://doi.org/10.1094/CCHEM.1998.75.6.815 CrossRef Loosveld A, Maes C, van Casteren WHM, Schols HA, Grobet PJ, Delcour JA (1998) Structural Variation and levels of water-extractable arabinogalactan-peptide in European wheat flours. Cereal Chem J 75:815–819. https://​doi.​org/​10.​1094/​CCHEM.​1998.​75.​6.​815 CrossRef

go back to reference Van den Bulck K, Loosveld A-MA, Courtin CM, Proost P, Van Damme J, Robben J, Mort A, Delcour JA (2002) Amino acid sequence of wheat flour arabinogalactan-peptide, identical to part of grain softness protein GSP-1, leads to improved structural model. Cereal Chem J 79:329–331. https://doi.org/10.1094/CCHEM.2002.79.3.329 CrossRef Van den Bulck K, Loosveld A-MA, Courtin CM, Proost P, Van Damme J, Robben J, Mort A, Delcour JA (2002) Amino acid sequence of wheat flour arabinogalactan-peptide, identical to part of grain softness protein GSP-1, leads to improved structural model. Cereal Chem J 79:329–331. https://​doi.​org/​10.​1094/​CCHEM.​2002.​79.​3.​329 CrossRef

go back to reference Tryfona T, Liang H-C, Kotake T, Kaneko S, Marsh J, Ichinose H, Lovegrove A, Tsumuraya Y, Shewry PR, Stephens E, Dupree P (2010) Carbohydrate structural analysis of wheat flour arabinogalactan protein. Carbohydr Res 345:2648–2656. https://doi.org/10.1016/j.carres.2010.09.018 CrossRefPubMed Tryfona T, Liang H-C, Kotake T, Kaneko S, Marsh J, Ichinose H, Lovegrove A, Tsumuraya Y, Shewry PR, Stephens E, Dupree P (2010) Carbohydrate structural analysis of wheat flour arabinogalactan protein. Carbohydr Res 345:2648–2656. https://​doi.​org/​10.​1016/​j.​carres.​2010.​09.​018 CrossRefPubMed

go back to reference Wilkinson MD, Tosi P, Lovegrove A, Corol DI, Ward JL, Palmer R, Powers S, Passmore D, Webster G, Marcus SE (2017) The Gsp-1 genes encode the wheat arabinogalactan peptide. J Cereal Sci 74:155–164CrossRef Wilkinson MD, Tosi P, Lovegrove A, Corol DI, Ward JL, Palmer R, Powers S, Passmore D, Webster G, Marcus SE (2017) The Gsp-1 genes encode the wheat arabinogalactan peptide. J Cereal Sci 74:155–164CrossRef

go back to reference Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, Verbeke K, Reid G (2017) Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) Consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. https://doi.org/10.1038/nrgastro.2017.75 CrossRefPubMed Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, Verbeke K, Reid G (2017) Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) Consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. https://​doi.​org/​10.​1038/​nrgastro.​2017.​75 CrossRefPubMed

go back to reference Gibson GR, Roberfroid MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 125:1401–1412CrossRefPubMed Gibson GR, Roberfroid MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 125:1401–1412CrossRefPubMed

go back to reference Kolida S, Gibson GR (2007) Prebiotic capacity of inulin-type fructans. J Nutr 137:2503S–2506S. https://doi.org/10.1093/jn/137.11.2503S CrossRefPubMed Kolida S, Gibson GR (2007) Prebiotic capacity of inulin-type fructans. J Nutr 137:2503S–2506S. https://​doi.​org/​10.​1093/​jn/​137.​11.​2503S CrossRefPubMed

go back to reference Broekaert WF, Courtin CM, Verbeke K, Van de Wiele T, Verstraete W, Delcour JA (2011) Prebiotic and other health-related effects of cereal-derived arabinoxylans, arabinoxylan-oligosaccharides, and xylooligosaccharides. Crit Rev Food Sci Nutr 51:178–194. https://doi.org/10.1080/10408390903044768 CrossRefPubMed Broekaert WF, Courtin CM, Verbeke K, Van de Wiele T, Verstraete W, Delcour JA (2011) Prebiotic and other health-related effects of cereal-derived arabinoxylans, arabinoxylan-oligosaccharides, and xylooligosaccharides. Crit Rev Food Sci Nutr 51:178–194. https://​doi.​org/​10.​1080/​1040839090304476​8 CrossRefPubMed

go back to reference Carlson JL, Erickson JM, Hess JM, Gould TJ, Slavin JL (2017) Prebiotic dietary fiber and gut health: comparing the in vitro fermentations of beta-glucan, inulin and xylooligosaccharide. Nutrients 9:1361. https://doi.org/10.3390/nu9121361 CrossRefPubMedCentral Carlson JL, Erickson JM, Hess JM, Gould TJ, Slavin JL (2017) Prebiotic dietary fiber and gut health: comparing the in vitro fermentations of beta-glucan, inulin and xylooligosaccharide. Nutrients 9:1361. https://​doi.​org/​10.​3390/​nu9121361 CrossRefPubMedCentral

go back to reference Hughes SA, Shewry PR, Gibson GR, McCleary BV, Rastall RA (2008) In vitro fermentation of oat and barley derived β-glucans by human faecal microbiota: in vitro fermentation of cereal β-glucans. FEMS Microbiol Ecol 64:482–493. https://doi.org/10.1111/j.1574-6941.2008.00478.x CrossRefPubMed Hughes SA, Shewry PR, Gibson GR, McCleary BV, Rastall RA (2008) In vitro fermentation of oat and barley derived β-glucans by human faecal microbiota: in vitro fermentation of cereal β-glucans. FEMS Microbiol Ecol 64:482–493. https://​doi.​org/​10.​1111/​j.​1574-6941.​2008.​00478.​x CrossRefPubMed

go back to reference Marsh JT, Tryfona T, Powers SJ, Stephens E, Dupree P, Shewry PR, Lovegrove A (2011) Determination of the N-glycosylation patterns of seed proteins: applications to determine the authenticity and substantial equivalence of genetically modified (GM) crops. J Agric Food Chem 59:8779–8788. https://doi.org/10.1021/jf2010854 CrossRefPubMed Marsh JT, Tryfona T, Powers SJ, Stephens E, Dupree P, Shewry PR, Lovegrove A (2011) Determination of the N-glycosylation patterns of seed proteins: applications to determine the authenticity and substantial equivalence of genetically modified (GM) crops. J Agric Food Chem 59:8779–8788. https://​doi.​org/​10.​1021/​jf2010854 CrossRefPubMed

go back to reference Rycroft CE, Jones MR, Gibson GR, Rastall RA (2001) A comparative in vitro evaluation of the fermentation properties of prebiotic oligosaccharides. J Appl Microbiol 91:878–887. https://doi.org/10.1046/j.1365-2672.2001.01446.x CrossRefPubMed Rycroft CE, Jones MR, Gibson GR, Rastall RA (2001) A comparative in vitro evaluation of the fermentation properties of prebiotic oligosaccharides. J Appl Microbiol 91:878–887. https://​doi.​org/​10.​1046/​j.​1365-2672.​2001.​01446.​x CrossRefPubMed

go back to reference Rycroft CE, Jones MR, Gibson GR, Rastall RA (2001) Fermentation properties of gentio-oligosaccharides. Lett Appl Microbiol 32:156–161. https://doi.org/10.1046/j.1472-765x.2001.00875.x CrossRefPubMed Rycroft CE, Jones MR, Gibson GR, Rastall RA (2001) Fermentation properties of gentio-oligosaccharides. Lett Appl Microbiol 32:156–161. https://​doi.​org/​10.​1046/​j.​1472-765x.​2001.​00875.​x CrossRefPubMed

go back to reference Langendijk PS, Schut F, Jansen GJ, Raangs GC, Kamphuis GR, Wilkinson MH, Welling GW (1995) Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific 16S RRNA-targeted probes and its application in fecal samples. Appl Environ Microbiol 61:3069–3075CrossRefPubMedPubMedCentral Langendijk PS, Schut F, Jansen GJ, Raangs GC, Kamphuis GR, Wilkinson MH, Welling GW (1995) Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific 16S RRNA-targeted probes and its application in fecal samples. Appl Environ Microbiol 61:3069–3075CrossRefPubMedPubMedCentral

go back to reference Manz W, Amann R, Ludwig W, Vancanneyt M, Schleifer K-H (1996) Application of a suite of 16S RRNA-specific oligonucleotide probes designed to investigate bacteria of the phylum cytophaga-flavobacter-bacteroides in the natural environment. Microbiology 142:1097–1106CrossRefPubMed Manz W, Amann R, Ludwig W, Vancanneyt M, Schleifer K-H (1996) Application of a suite of 16S RRNA-specific oligonucleotide probes designed to investigate bacteria of the phylum cytophaga-flavobacter-bacteroides in the natural environment. Microbiology 142:1097–1106CrossRefPubMed

go back to reference Harmsen HJM, Elfferich P, Schut F, Welling GW (1999) A 16S RRNA-targeted probe for detection of lactobacilli and enterococci in faecal samples by fluorescent in situ hybridization. Microb Ecol Health Dis. https://doi.org/10.3402/mehd.v11i1.7876 CrossRef Harmsen HJM, Elfferich P, Schut F, Welling GW (1999) A 16S RRNA-targeted probe for detection of lactobacilli and enterococci in faecal samples by fluorescent in situ hybridization. Microb Ecol Health Dis. https://​doi.​org/​10.​3402/​mehd.​v11i1.​7876 CrossRef

go back to reference Harmsen HJM, Wildeboer-Veloo ACM, Grijpstra J, Knol J, Degener JE, Welling GW (2000) Development of 16S RRNA-based probes for the coriobacterium group and the atopobium cluster and their application for enumeration of coriobacteriaceae in human feces from volunteers of different age groups. Appl Environ Microbiol 66:4523–4527. https://doi.org/10.1128/AEM.66.10.4523-4527.2000 CrossRefPubMedPubMedCentral Harmsen HJM, Wildeboer-Veloo ACM, Grijpstra J, Knol J, Degener JE, Welling GW (2000) Development of 16S RRNA-based probes for the coriobacterium group and the atopobium cluster and their application for enumeration of coriobacteriaceae in human feces from volunteers of different age groups. Appl Environ Microbiol 66:4523–4527. https://​doi.​org/​10.​1128/​AEM.​66.​10.​4523-4527.​2000 CrossRefPubMedPubMedCentral

go back to reference Walker AW, Duncan SH, McWilliam Leitch EC, Child MW, Flint HJ (2005) PH and peptide supply can radically alter bacterial populations and short-chain fatty acid ratios within microbial communities from the human colon. Appl Environ Microbiol 71:3692–3700. https://doi.org/10.1128/AEM.71.7.3692-3700.2005 CrossRefPubMedPubMedCentral Walker AW, Duncan SH, McWilliam Leitch EC, Child MW, Flint HJ (2005) PH and peptide supply can radically alter bacterial populations and short-chain fatty acid ratios within microbial communities from the human colon. Appl Environ Microbiol 71:3692–3700. https://​doi.​org/​10.​1128/​AEM.​71.​7.​3692-3700.​2005 CrossRefPubMedPubMedCentral

go back to reference Franks AH, Harmsen HJ, Raangs GC, Jansen GJ, Schut F, Welling GW (1998) Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specific 16S RRNA-targeted oligonucleotide probes. Appl Environ Microbiol 64:3336–3345CrossRefPubMedPubMedCentral Franks AH, Harmsen HJ, Raangs GC, Jansen GJ, Schut F, Welling GW (1998) Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specific 16S RRNA-targeted oligonucleotide probes. Appl Environ Microbiol 64:3336–3345CrossRefPubMedPubMedCentral

go back to reference Hold GL, Schwiertz A, Aminov RI, Blaut M, Flint HJ (2003) Oligonucleotide probes that detect quantitatively significant groups of butyrate-producing bacteria in human feces. Appl Environ Microbiol 69:4320–4324. https://doi.org/10.1128/AEM.69.7.4320-4324.2003 CrossRefPubMedPubMedCentral Hold GL, Schwiertz A, Aminov RI, Blaut M, Flint HJ (2003) Oligonucleotide probes that detect quantitatively significant groups of butyrate-producing bacteria in human feces. Appl Environ Microbiol 69:4320–4324. https://​doi.​org/​10.​1128/​AEM.​69.​7.​4320-4324.​2003 CrossRefPubMedPubMedCentral

go back to reference Ciucanu I, Kerek F (1984) A simple and rapid method for the permethylation of carbohydrates. Carbohydr Res 131:209–217. https://doi.org/10.1016/0008-6215(84)85242-8 CrossRef Ciucanu I, Kerek F (1984) A simple and rapid method for the permethylation of carbohydrates. Carbohydr Res 131:209–217. https://​doi.​org/​10.​1016/​0008-6215(84)85242-8 CrossRef

go back to reference Snart J, Bibiloni R, Grayson T, Lay C, Zhang H, Allison GE, Laverdiere JK, Temelli F, Vasanthan T, Bell R, Tannock GW (2006) Supplementation of the diet with high-viscosity beta-glucan results in enrichment for lactobacilli in the rat cecum. Appl Environ Microbiol 72:1925–1931. https://doi.org/10.1128/AEM.72.3.1925-1931.2006 CrossRefPubMedPubMedCentral Snart J, Bibiloni R, Grayson T, Lay C, Zhang H, Allison GE, Laverdiere JK, Temelli F, Vasanthan T, Bell R, Tannock GW (2006) Supplementation of the diet with high-viscosity beta-glucan results in enrichment for lactobacilli in the rat cecum. Appl Environ Microbiol 72:1925–1931. https://​doi.​org/​10.​1128/​AEM.​72.​3.​1925-1931.​2006 CrossRefPubMedPubMedCentral

go back to reference Hughes SA, Shewry PR, Li L, Gibson GR, Sanz ML, Rastall RA (2007) In vitro fermentation by human fecal microflora of wheat arabinoxylans. J Agric Food Chem 55:4589–4595. https://doi.org/10.1021/jf070293g CrossRefPubMed Hughes SA, Shewry PR, Li L, Gibson GR, Sanz ML, Rastall RA (2007) In vitro fermentation by human fecal microflora of wheat arabinoxylans. J Agric Food Chem 55:4589–4595. https://​doi.​org/​10.​1021/​jf070293g CrossRefPubMed

go back to reference Cummings JH (1981) Short chain fatty acids in the human colon. Gut 22:763CrossRefPubMedPubMedCentral Cummings JH (1981) Short chain fatty acids in the human colon. Gut 22:763CrossRefPubMedPubMedCentral

go back to reference Cummings JH, Macfarlane GT (1997) Colonic microflora: nutrition and health. Nutrition 13:476–478CrossRefPubMed Cummings JH, Macfarlane GT (1997) Colonic microflora: nutrition and health. Nutrition 13:476–478CrossRefPubMed

go back to reference Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto J-M, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, Hansen T, Hattori M, Hayashi T, Kleerebezem M, Kurokawa K, Leclerc M, Levenez F, Manichanh C, Nielsen HB, Nielsen T, Pons N, Poulain J, Qin J, Sicheritz-Ponten T, Tims S, Torrents D, Ugarte E, Zoetendal EG, Wang J, Guarner F, Pedersen O, de Vos WM, Brunak S, Doré J, Antolín M, Artiguenave F, Blottiere HM, Almeida M, Brechot C, Cara C, Chervaux C, Cultrone A, Delorme C, Denariaz G, Dervyn R, Foerstner KU, Friss C, van de Guchte M, Guedon E, Haimet F, Huber W, van Hylckama-Vlieg J, Jamet A, Juste C, Kaci G, Knol J, Lakhdari O, Layec S, Le Roux K, Maguin E, Mérieux A, Melo Minardi R, M’rini C, Muller J, Oozeer R, Parkhill J, Renault P, Rescigno M, Sanchez N, Sunagawa S, Torrejon A, Turner K, Vandemeulebrouck G, Varela E, Winogradsky Y, Zeller G, Weissenbach J, Ehrlich SD, Bork P (2011) Enterotypes of the human gut microbiome. Nature 473:174–180. https://doi.org/10.1038/nature09944 CrossRefPubMedPubMedCentral Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto J-M, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, Hansen T, Hattori M, Hayashi T, Kleerebezem M, Kurokawa K, Leclerc M, Levenez F, Manichanh C, Nielsen HB, Nielsen T, Pons N, Poulain J, Qin J, Sicheritz-Ponten T, Tims S, Torrents D, Ugarte E, Zoetendal EG, Wang J, Guarner F, Pedersen O, de Vos WM, Brunak S, Doré J, Antolín M, Artiguenave F, Blottiere HM, Almeida M, Brechot C, Cara C, Chervaux C, Cultrone A, Delorme C, Denariaz G, Dervyn R, Foerstner KU, Friss C, van de Guchte M, Guedon E, Haimet F, Huber W, van Hylckama-Vlieg J, Jamet A, Juste C, Kaci G, Knol J, Lakhdari O, Layec S, Le Roux K, Maguin E, Mérieux A, Melo Minardi R, M’rini C, Muller J, Oozeer R, Parkhill J, Renault P, Rescigno M, Sanchez N, Sunagawa S, Torrejon A, Turner K, Vandemeulebrouck G, Varela E, Winogradsky Y, Zeller G, Weissenbach J, Ehrlich SD, Bork P (2011) Enterotypes of the human gut microbiome. Nature 473:174–180. https://​doi.​org/​10.​1038/​nature09944 CrossRefPubMedPubMedCentral

go back to reference Singh J, Rivenson A, Tomita M, Shimamura S, Ishibashi N, Reddy BS (1997) Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulates the intermediate biomarkers of colon carcinogenesis. Carcinogenesis 18:833–841CrossRefPubMed Singh J, Rivenson A, Tomita M, Shimamura S, Ishibashi N, Reddy BS (1997) Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulates the intermediate biomarkers of colon carcinogenesis. Carcinogenesis 18:833–841CrossRefPubMed

go back to reference Zanotti I, Turroni F, Piemontese A, Mancabelli L, Milani C, Viappiani A, Prevedini G, Sanchez B, Margolles A, Elviri L (2015) Evidence for cholesterol-lowering activity by Bifidobacterium bifidum PRL2010 through gut microbiota modulation. Appl Microbiol Biotechnol 99:6813–6829CrossRefPubMed Zanotti I, Turroni F, Piemontese A, Mancabelli L, Milani C, Viappiani A, Prevedini G, Sanchez B, Margolles A, Elviri L (2015) Evidence for cholesterol-lowering activity by Bifidobacterium bifidum PRL2010 through gut microbiota modulation. Appl Microbiol Biotechnol 99:6813–6829CrossRefPubMed

go back to reference Rivière A, Selak M, Lantin D, Leroy F, De Vuyst L (2016) Bifidobacteria and butyrate-producing colon bacteria: importance and strategies for their stimulation in the human gut. Front Microbiol. https://doi.org/10.3389/fmicb.2016.00979 CrossRefPubMedPubMedCentral Rivière A, Selak M, Lantin D, Leroy F, De Vuyst L (2016) Bifidobacteria and butyrate-producing colon bacteria: importance and strategies for their stimulation in the human gut. Front Microbiol. https://​doi.​org/​10.​3389/​fmicb.​2016.​00979 CrossRefPubMedPubMedCentral

go back to reference Kurakawa T, Ogata K, Matsuda K, Tsuji H, Kubota H, Takada T, Kado Y, Asahara T, Takahashi T, Nomoto K (2015) Diversity of intestinal clostridium coccoides group in the Japanese population, as demonstrated by reverse transcription-quantitative PCR. Popoff, M.R., Ed. PLoS One 10:e0126226. https://doi.org/10.1371/journal.pone.0126226 CrossRefPubMedPubMedCentral Kurakawa T, Ogata K, Matsuda K, Tsuji H, Kubota H, Takada T, Kado Y, Asahara T, Takahashi T, Nomoto K (2015) Diversity of intestinal clostridium coccoides group in the Japanese population, as demonstrated by reverse transcription-quantitative PCR. Popoff, M.R., Ed. PLoS One 10:e0126226. https://​doi.​org/​10.​1371/​journal.​pone.​0126226 CrossRefPubMedPubMedCentral

go back to reference Stewart ML, Timm DA, Slavin JL (2008) Fructooligosaccharides exhibit more rapid fermentation than long-chain inulin in an in vitro fermentation system. Nutrition Research 28:329–334CrossRefPubMed Stewart ML, Timm DA, Slavin JL (2008) Fructooligosaccharides exhibit more rapid fermentation than long-chain inulin in an in vitro fermentation system. Nutrition Research 28:329–334CrossRefPubMed

go back to reference Fincher GB, Sawyer WH, Stone BA (1974) Chemical and physical properties of an arabinogalactan-peptide from wheat endosperm. Biochem J 139:535–545. https://doi.org/10.1042/bj1390535 CrossRefPubMedPubMedCentral Fincher GB, Sawyer WH, Stone BA (1974) Chemical and physical properties of an arabinogalactan-peptide from wheat endosperm. Biochem J 139:535–545. https://​doi.​org/​10.​1042/​bj1390535 CrossRefPubMedPubMedCentral

go back to reference Izydorczyk M, Biliaderis CG, Bushuk W (1991) Comparison of the structure and composition of water-soluble pentosans from different wheat varieties. Cereal Chem 68:139–144 Izydorczyk M, Biliaderis CG, Bushuk W (1991) Comparison of the structure and composition of water-soluble pentosans from different wheat varieties. Cereal Chem 68:139–144

go back to reference Van den Bulck K, Swennen K, Loosveld A-MA, Courtin CM, Brijs K, Proost P, Van Damme J, Van Campenhout S, Mort A, Delcour JA (2005) Isolation of cereal arabinogalactan-peptides and structural comparison of their carbohydrate and peptide moieties. J Cereal Sci 41:59–67CrossRef Van den Bulck K, Swennen K, Loosveld A-MA, Courtin CM, Brijs K, Proost P, Van Damme J, Van Campenhout S, Mort A, Delcour JA (2005) Isolation of cereal arabinogalactan-peptides and structural comparison of their carbohydrate and peptide moieties. J Cereal Sci 41:59–67CrossRef

go back to reference Macfarlane GT, Gibson GR, Cummings JH (1992) Comparison of fermentation reactions in different regions of the human colon. J Appl Bacteriol 72:57–64PubMed Macfarlane GT, Gibson GR, Cummings JH (1992) Comparison of fermentation reactions in different regions of the human colon. J Appl Bacteriol 72:57–64PubMed

go back to reference Van Laere KMJ, Hartemink R, Bosveld M, Schols HA, Voragen AGJ (2000) Fermentation of plant cell wall derived polysaccharides and their corresponding oligosaccharides by intestinal bacteria. J Agric Food Chem 48:1644–1652. https://doi.org/10.1021/jf990519i CrossRefPubMed Van Laere KMJ, Hartemink R, Bosveld M, Schols HA, Voragen AGJ (2000) Fermentation of plant cell wall derived polysaccharides and their corresponding oligosaccharides by intestinal bacteria. J Agric Food Chem 48:1644–1652. https://​doi.​org/​10.​1021/​jf990519i CrossRefPubMed

go back to reference Khalil NA, Walton GE, Gibson GR, Tuohy KM, Andrews SC (2014) In vitro batch cultures of gut microbiota from healthy and ulcerative colitis (UC) subjects suggest that sulphate-reducing bacteria levels are raised in UC and by a protein-rich diet. Int J Food Sci Nutr 65:79–88. https://doi.org/10.3109/09637486.2013.825700 CrossRefPubMed Khalil NA, Walton GE, Gibson GR, Tuohy KM, Andrews SC (2014) In vitro batch cultures of gut microbiota from healthy and ulcerative colitis (UC) subjects suggest that sulphate-reducing bacteria levels are raised in UC and by a protein-rich diet. Int J Food Sci Nutr 65:79–88. https://​doi.​org/​10.​3109/​09637486.​2013.​825700 CrossRefPubMed

go back to reference Coutinho CMLM, Coutinho-Silva R, Zinkevich V, Pearce CB, Ojcius DM, Beech I (2017) Sulphate-reducing bacteria from ulcerative colitis patients induce apoptosis of gastrointestinal epithelial cells. Microb Pathog 112:126–134CrossRefPubMed Coutinho CMLM, Coutinho-Silva R, Zinkevich V, Pearce CB, Ojcius DM, Beech I (2017) Sulphate-reducing bacteria from ulcerative colitis patients induce apoptosis of gastrointestinal epithelial cells. Microb Pathog 112:126–134CrossRefPubMed

go back to reference Rowan FE, Docherty NG, Coffey JC, O’Connell PR (2009) Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis. Br J Surg 96:151–158. https://doi.org/10.1002/bjs.6454 CrossRefPubMed Rowan FE, Docherty NG, Coffey JC, O’Connell PR (2009) Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis. Br J Surg 96:151–158. https://​doi.​org/​10.​1002/​bjs.​6454 CrossRefPubMed

go back to reference Windey K, De Preter V, Verbeke K (2012) Relevance of protein fermentation to gut health. Mol Nutr Food Res 56:184–196. https://doi.org/10.1002/mnfr.201100542 CrossRefPubMed Windey K, De Preter V, Verbeke K (2012) Relevance of protein fermentation to gut health. Mol Nutr Food Res 56:184–196. https://​doi.​org/​10.​1002/​mnfr.​201100542 CrossRefPubMed

go back to reference Roberfroid M, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I, Wolvers D, Watzl B, Szajewska H, Stahl B, Guarner F, Respondek F, Whelan K, Coxam V, Davicco M-J, Léotoing L, Wittrant Y, Delzenne NM, Cani PD, Neyrinck AM, Meheust A (2010) Prebiotic effects: metabolic and health benefits. Br J Nutr 104:S1–S63. https://doi.org/10.1017/S0007114510003363 CrossRefPubMed Roberfroid M, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I, Wolvers D, Watzl B, Szajewska H, Stahl B, Guarner F, Respondek F, Whelan K, Coxam V, Davicco M-J, Léotoing L, Wittrant Y, Delzenne NM, Cani PD, Neyrinck AM, Meheust A (2010) Prebiotic effects: metabolic and health benefits. Br J Nutr 104:S1–S63. https://​doi.​org/​10.​1017/​S000711451000336​3 CrossRefPubMed

go back to reference Fincher GB, Stone BA (1974) A water-soluble arabinogalactan-peptide from wheat endosperm. Aust J Biol Sci 27:117–132CrossRef Fincher GB, Stone BA (1974) A water-soluble arabinogalactan-peptide from wheat endosperm. Aust J Biol Sci 27:117–132CrossRef

go back to reference Blaut M (2002) Relationship of prebiotics and food to intestinal microflora. Eur J Nutr 41:i11–i16CrossRefPubMed Blaut M (2002) Relationship of prebiotics and food to intestinal microflora. Eur J Nutr 41:i11–i16CrossRefPubMed

go back to reference Vinolo MAR, Rodrigues HG, Nachbar RT, Curi R (2011) Regulation of inflammation by short chain fatty acids. Nutrients 3:858–876. https://doi.org/10.3390/nu3100858 CrossRefPubMedPubMedCentral Vinolo MAR, Rodrigues HG, Nachbar RT, Curi R (2011) Regulation of inflammation by short chain fatty acids. Nutrients 3:858–876. https://​doi.​org/​10.​3390/​nu3100858 CrossRefPubMedPubMedCentral

go back to reference Dass NB, John AK, Bassil AK, Crumbley CW, Shehee WR, Maurio FP, Moore GBT, Taylor CM, Sanger GJ (2007) The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation. Neurogastroenterol Motil 19:66–74CrossRefPubMed Dass NB, John AK, Bassil AK, Crumbley CW, Shehee WR, Maurio FP, Moore GBT, Taylor CM, Sanger GJ (2007) The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation. Neurogastroenterol Motil 19:66–74CrossRefPubMed

go back to reference Morrison DJ, Preston T (2016) Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes 7:189–200. https://doi.org/10.1080/19490976.2015.1134082 CrossRefPubMedPubMedCentral Morrison DJ, Preston T (2016) Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes 7:189–200. https://​doi.​org/​10.​1080/​19490976.​2015.​1134082 CrossRefPubMedPubMedCentral

go back to reference Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DL, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M, Ohno H (2011) Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469:543–547. https://doi.org/10.1038/nature09646 CrossRefPubMed Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DL, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M, Ohno H (2011) Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469:543–547. https://​doi.​org/​10.​1038/​nature09646 CrossRefPubMed

go back to reference Bindels LB, Delzenne NM, Cani PD, Walter J (2015) Towards a more comprehensive concept for prebiotics. Nat Rev Gastroenterol Hepatol 12:303CrossRefPubMed Bindels LB, Delzenne NM, Cani PD, Walter J (2015) Towards a more comprehensive concept for prebiotics. Nat Rev Gastroenterol Hepatol 12:303CrossRefPubMed

go back to reference Kamlage B, Gruhl R, Blaut M (1997) Isolation and characterization of two new homoacetogenic hydrogen-utilizing bacteria from the human intestinal tract that are closely related to clostridium coccoides. Appl Environ Microbiol 63:7CrossRef Kamlage B, Gruhl R, Blaut M (1997) Isolation and characterization of two new homoacetogenic hydrogen-utilizing bacteria from the human intestinal tract that are closely related to clostridium coccoides. Appl Environ Microbiol 63:7CrossRef

go back to reference Duncan SH, Louis P, Flint HJ (2004) Lactate-utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product. Appl Environ Microbiol 70:5810–5817. https://doi.org/10.1128/AEM.70.10.5810-5817.2004 CrossRefPubMedPubMedCentral Duncan SH, Louis P, Flint HJ (2004) Lactate-utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product. Appl Environ Microbiol 70:5810–5817. https://​doi.​org/​10.​1128/​AEM.​70.​10.​5810-5817.​2004 CrossRefPubMedPubMedCentral

go back to reference Belenguer A, Holtrop G, Duncan SH, Anderson SE, Calder AG, Flint HJ, Lobley GE (2011) Rates of production and utilization of lactate by microbial communities from the human colon. FEMS Microbiol Ecol 77:107–119CrossRefPubMed Belenguer A, Holtrop G, Duncan SH, Anderson SE, Calder AG, Flint HJ, Lobley GE (2011) Rates of production and utilization of lactate by microbial communities from the human colon. FEMS Microbiol Ecol 77:107–119CrossRefPubMed

go back to reference Barcenilla A, Pryde SE, Martin JC, Duncan SH, Stewart CS, Henderson C, Flint HJ (2000) Phylogenetic relationships of butyrate-producing bacteria from the human gut. Appl Environ Microbiol 66:1654–1661CrossRefPubMedPubMedCentral Barcenilla A, Pryde SE, Martin JC, Duncan SH, Stewart CS, Henderson C, Flint HJ (2000) Phylogenetic relationships of butyrate-producing bacteria from the human gut. Appl Environ Microbiol 66:1654–1661CrossRefPubMedPubMedCentral

go back to reference Bourriaud C, Robins RJ, Martin L, Kozlowski F, Tenailleau E, Cherbut C, Michel C (2005) Lactate is mainly fermented to butyrate by human intestinal microfloras but inter-individual variation is evident. J Appl Microbiol 99:201–212. https://doi.org/10.1111/j.1365-2672.2005.02605.x CrossRefPubMed Bourriaud C, Robins RJ, Martin L, Kozlowski F, Tenailleau E, Cherbut C, Michel C (2005) Lactate is mainly fermented to butyrate by human intestinal microfloras but inter-individual variation is evident. J Appl Microbiol 99:201–212. https://​doi.​org/​10.​1111/​j.​1365-2672.​2005.​02605.​x CrossRefPubMed

go back to reference Louis P, Young P, Holtrop G, Flint HJ (2010) Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene. Environ Microbiol 12:304–314. https://doi.org/10.1111/j.1462-2920.2009.02066.x CrossRefPubMed Louis P, Young P, Holtrop G, Flint HJ (2010) Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene. Environ Microbiol 12:304–314. https://​doi.​org/​10.​1111/​j.​1462-2920.​2009.​02066.​x CrossRefPubMed

go back to reference Pham VT, Lacroix C, Braegger CP, Chassard C (2017) Lactate-utilizing community is associated with gut microbiota dysbiosis in colicky infants. Sci Rep. https://doi.org/10.1038/s41598-017-11509-1 CrossRefPubMedPubMedCentral Pham VT, Lacroix C, Braegger CP, Chassard C (2017) Lactate-utilizing community is associated with gut microbiota dysbiosis in colicky infants. Sci Rep. https://​doi.​org/​10.​1038/​s41598-017-11509-1 CrossRefPubMedPubMedCentral