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01-04-2014 | Neurology and Preclinical Neurological Studies - Short communication

Clinical subtypes in Parkinson’s disease: the impact of MAPT haplotypes

Authors: Maria Elena Di Battista, Esterina Pascale, Carlo Purcaro, Francesca Passarelli, Emanuela Passarelli, Renzo Guglielmi, Nicola Vanacore, Giuseppe Meco

Published in: Journal of Neural Transmission | Issue 4/2014

Abstract

The H1 haplotype of the MAPT gene influences the risk of PD and has been related to the development of PDD. We evaluated the influence of MAPT haplotypes on the expression of motor features in PD patients. We genotyped, for the MAPT haplotypes H1 and H2, a sample of 181 PD patients with distinct clinical subtypes: tremor dominant and non-tremor dominant (NTD). Our results indicate that the MAPT haplotypes contribute to the expression of motor features of PD. H1 homozygous PD patients are significantly more likely to present a NTD phenotype, a clinical subtype characterized by widespread pathological degeneration, than H2 carriers.

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Title: Clinical subtypes in Parkinson’s disease: the impact of MAPT haplotypes
Authors: Maria Elena Di Battista
Esterina Pascale
Carlo Purcaro
Francesca Passarelli
Emanuela Passarelli
Renzo Guglielmi
Nicola Vanacore
Giuseppe Meco
Publication date: 01-04-2014
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 4/2014
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-1117-7

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Clinical subtypes in Parkinson’s disease: the impact of MAPT haplotypes

Abstract

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Springer Medicine

Abstract

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