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01-04-2014 | Psychiatry and Preclinical Psychiatric Studies - Short communication

Change in electrodermal activity after acute tryptophan depletion associated with aggression in young people with attention deficit hyperactivity disorder (ADHD)

Authors: G. G. von Polier, C. S. Biskup, W. F. Kötting, S. Bubenzer, K. Helmbold, A. Eisert, T. J. Gaber, F. D. Zepf

Published in: Journal of Neural Transmission | Issue 4/2014

Abstract

We investigated the impact of acute tryptophan depletion (ATD) and reduced brain serotonin synthesis on physiological arousal in 15 young people with ADHD participating in an aggression-inducing game. ATD was not associated with altered physiological arousal, as indexed by electrodermal activity (EDA). Baseline aggression was negatively correlated with the mean ATD effect on EDA. In accordance with the low arousal theory related to aggressive behavior, subjects with reduced physiological responsiveness/lower electrodermal reactivity to ATD tended to display elevated externalizing behavior.

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Title: Change in electrodermal activity after acute tryptophan depletion associated with aggression in young people with attention deficit hyperactivity disorder (ADHD)
Authors: G. G. von Polier
C. S. Biskup
W. F. Kötting
S. Bubenzer
K. Helmbold
A. Eisert
T. J. Gaber
F. D. Zepf
Publication date: 01-04-2014
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 4/2014
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-1119-5

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Change in electrodermal activity after acute tryptophan depletion associated with aggression in young people with attention deficit hyperactivity disorder (ADHD)

Abstract

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Abstract

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