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Critical Care
Published in: Critical Care 1/2015

01-12-2015 | Letter

Clinical solutions: not always what they seem?

Authors: Anne Burke-Gaffney, Benedict C Creagh-Brown

Published in: Critical Care | Issue 1/2015

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Excerpt

Brenner and colleagues [1], in their article published in Critical Care, showed elevated levels of the reactive carbonyl species (RCS) methylglyoxal (MG) in the circulation of patients with septic shock. We commend the authors’ bravery in launching this molecule into a field well-populated with biomarkers and where clinical diagnosis persists as the ‘gold standard’ [2]. …
Literature
1.
Brenner T, Fleming T, Uhle F, Silaff S, Schmitt F, Salgado E, et al. Methylglyoxal as a new biomarker in patients with septic shock: an observational clinical study. Crit Care. 2014;18:683.CrossRef
2.
Prucha M, Bellingan G, Zazula R. Sepsis biomarkers. Clin Chim Acta. 2015;440c:97–103.CrossRef
3.
Hirahara I, Kusano E, Yanagiba S, Miyata Y, Ando Y, Muto S, et al. Peritoneal injury by methylglyoxal in peritoneal dialysis. Perit Dial Int. 2006;26:380–92.CrossRef
4.
Inagi R, Miyata T, Ueda Y, Yoshino A, Nangaku M, van Ypersele Strihou de C, et al. Efficient in vitro lowering of carbonyl stress by the glyoxalase system in conventional glucose peritoneal dialysis fluid. Kidney Int. 2002;62:679–87.CrossRef
Metadata
Title
Clinical solutions: not always what they seem?
Authors
Anne Burke-Gaffney
Benedict C Creagh-Brown
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2015
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-015-0870-4

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