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Keynote webinar | Spotlight on medication adherence

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Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
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Annals of Hematology
Published in: Annals of Hematology 7/2016

01-06-2016 | Letter to the Editor

Clinical response to ruxolitinib in CSF3R T618-mutated chronic neutrophilic leukemia

Authors: Maximilian Stahl, Mina L. Xu, David P. Steensma, Raajit Rampal, Melissa Much, Amer M Zeidan

Published in: Annals of Hematology | Issue 7/2016

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Excerpt

Dear Editor, …
Literature
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Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, Bottomly D, Wilmot B, McWeeney SK, Tognon CE, Pond JB, Collins RH, Goueli B, Oh ST, Deininger MW, Chang BH, Loriaux MM, Druker BJ, Tyner JW (2013) Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med 368(19):1781–1790. doi:10.​1056/​NEJMoa1214514 CrossRefPubMedPubMedCentral
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Dao KH, Solti MB, Maxson JE, Winton EF, Press RD, Druker BJ, Tyner JW (2014) Significant clinical response to JAK1/2 inhibition in a patient with CSF3R-T618I-positive atypical chronic myeloid leukemia. Leukemia Res Rep 3(2):67–69. doi:10.​1016/​j.​lrr.​2014.​07.​002 CrossRef
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Lasho TL, Mims A, Elliott MA, Finke C, Pardanani A, Tefferi A (2014) Chronic neutrophilic leukemia with concurrent CSF3R and SETBP1 mutations: single colony clonality studies, in vitro sensitivity to JAK inhibitors and lack of treatment response to ruxolitinib. Leukemia 28(6):1363–1365. doi:10.​1038/​leu.​2014.​39 CrossRefPubMed
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Makishima H, Yoshida K, Nguyen N, Przychodzen B, Sanada M, Okuno Y, Ng KP, Gudmundsson KO, Vishwakarma BA, Jerez A, Gomez-Segui I, Takahashi M, Shiraishi Y, Nagata Y, Guinta K, Mori H, Sekeres MA, Chiba K, Tanaka H, Muramatsu H, Sakaguchi H, Paquette RL, McDevitt MA, Kojima S, Saunthararajah Y, Miyano S, Shih LY, Du Y, Ogawa S, Maciejewski JP (2013) Somatic SETBP1 mutations in myeloid malignancies. Nat Genet 45(8):942–946. doi:10.​1038/​ng.​2696 CrossRefPubMedPubMedCentral
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Elliott MA, Pardanani A, Hanson CA, Lasho TL, Finke CM, Belachew AA, Tefferi A (2015) ASXL1 mutations are frequent and prognostically detrimental in CSF3R-mutated chronic neutrophilic leukemia. Am J Hematol 90(7):653–656. doi:10.​1002/​ajh.​24031 CrossRefPubMed
Metadata
Title
Clinical response to ruxolitinib in CSF3R T618-mutated chronic neutrophilic leukemia
Authors
Maximilian Stahl
Mina L. Xu
David P. Steensma
Raajit Rampal
Melissa Much
Amer M Zeidan
Publication date
01-06-2016
Publisher
Springer Berlin Heidelberg
Published in
Annals of Hematology / Issue 7/2016
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-016-2664-4

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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