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Pediatric Cardiology
Published in: Pediatric Cardiology 5/2013

01-06-2013 | Letter to the Editor

Clinical Implications of a New Model of Kawasaki Disease Arteriopathy

Authors: Anne H. Rowley, Jan M. Orenstein

Published in: Pediatric Cardiology | Issue 5/2013

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Excerpt

Our recent light and electron microscopic study investigating 41 cases of Kawasaki disease (KD) [4] identified three distinct and apparently related pathologic processes that challenge long-held views [1, 2] concerning the history and fate of the arteriopathy and coronary artery aneurysms (CAAs): necrotizing arteritis (NA), subacute/chronic (SA/C) vasculitis, and luminal myofibroblastic proliferation (LMP). These findings have implications for the study of myofibroblasts, wound healing, vasculitis, myocarditis, and atherosclerosis, as well as significant clinical implications for KD. …
Literature
1.
Amano S, Hazama F, Hamashima Y (1979) Pathology of Kawasaki disease: I. Pathology and morphogenesis of the vascular changes. Jpn Circ J 43:633–643PubMedCrossRef
2.
Fujiwara H, Hamashima Y (1978) Pathology of the heart in Kawasaki disease. Pediatrics 61:100–107PubMed
3.
Landing BH, Larson EJ (1987) Pathological features of Kawasaki disease (mucocutaneous lymph node syndrome). Am J Cardiovasc Pathol 1:218–229PubMed
4.
Orenstein JM, Shulman ST, Fox LM et al (2012) Three linked vasculopathic processes characterize Kawasaki disease: a light and transmission electron microscopic study. PLoS ONE 7:e38998PubMedCrossRef
5.
Rowley AH, Baker SC, Shulman ST et al (2011) Ultrastructural, immunofluorescence, and RNA evidence support the hypothesis of a “new” virus associated with Kawasaki disease. J Infect Dis 203:1021–1030PubMedCrossRef
Metadata
Title
Clinical Implications of a New Model of Kawasaki Disease Arteriopathy
Authors
Anne H. Rowley
Jan M. Orenstein
Publication date
01-06-2013
Publisher
Springer-Verlag
Published in
Pediatric Cardiology / Issue 5/2013
Print ISSN: 0172-0643
Electronic ISSN: 1432-1971
DOI
https://doi.org/10.1007/s00246-013-0660-1

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