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European Journal of Nuclear Medicine and Molecular Imaging

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01-07-2017 | Short Communication

Clinical feasibility of ⁹⁰Y digital PET/CT for imaging microsphere biodistribution following radioembolization

Authors: Chadwick L. Wright, Katherine Binzel, Jun Zhang, Evan J. Wuthrick, Michael V. Knopp

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 7/2017

Abstract

Purpose

The purpose of this study was to evaluate the clinical feasibility of next generation solid-state digital photon counting PET/CT (dPET/CT) technology and imaging findings in patients following ⁹⁰Y microsphere radioembolization in comparison with standard of care (SOC) bremsstrahlung SPECT/CT (bSPECT/CT).

Methods

Five patients underwent SOC ⁹⁰Y bremsstrahlung imaging immediately following routine radioembolization with 3.5 ± 1.7 GBq of ⁹⁰Y-labeled glass microspheres. All patients also underwent dPET/CT imaging at 29 ± 11 h following radioembolization. Matched pairs comparison was used to compare image quality, image contrast and ⁹⁰Y biodistribution between dPET/CT and bSPECT/CT images. Volumetric assessments of ⁹⁰Y activity using different isocontour thresholds on dPET/CT and bSPECT/CT images were also compared.

Results

Digital PET/CT consistently provided better visual image quality and ⁹⁰Y-to-background image contrast while depicting ⁹⁰Y biodistribution than bSPECT/CT. Isocontour volumetric assessment using a 1% threshold precisely outlined ⁹⁰Y activity and the treatment volume on dPET/CT images, whereas a more restrictive 20% threshold on bSPECT/CT images was needed to obtain comparable treatment volumes. The use of a less restrictive 10% threshold isocontour on bSPECT/CT images grossly overestimated the treatment volume when compared with the 1% threshold on dPET/CT images.

Conclusions

Digital PET/CT is clinically feasible for the assessment of ⁹⁰Y microsphere biodistribution following radioembolization, and provides better visual image quality and image contrast than routine bSPECT/CT with comparable acquisition times. With further optimization and clinical validation, dPET technology may allow faster and more accurate imaging-based assessment of ⁹⁰Y microsphere biodistribution.

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Title: Clinical feasibility of 90Y digital PET/CT for imaging microsphere biodistribution following radioembolization
Authors: Chadwick L. Wright
Katherine Binzel
Jun Zhang
Evan J. Wuthrick
Michael V. Knopp
Publication date: 01-07-2017
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 7/2017
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-017-3694-4

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Springer Medicine

Clinical feasibility of ⁹⁰Y digital PET/CT for imaging microsphere biodistribution following radioembolization

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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