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Journal of Gastrointestinal Surgery

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01-06-2013 | 2012 SSAT Plenary Presentation

Chronic Use of PPI and H₂ Antagonists Decreases the Risk of Pouchitis After IPAA for Ulcerative Colitis

Authors: Lisa S. Poritz, Rishabh Sehgal, Arthur S. Berg, Lacee Laufenberg, Christine Choi, Emmanuelle D. Williams

Published in: Journal of Gastrointestinal Surgery | Issue 6/2013

Abstract

Introduction

Bacteria have been implicated in the development of pouchitis after ileal pouch anal anastomosis. The change in gastric pH with the use of proton pump inhibitors and H₂ antagonists may lead to alteration of enteric bacteria. We hypothesized that chronic use of these medications would decrease the incidence of pouchitis.

Methods

Patients who had undergone ileal pouch anal anastomosis for ulcerative colitis were classified by history of pouchitis. Patients were further classified by their use of proton pump inhibitors, H₂ blockers, antacids, and other known risk factors for pouchitis.

Results

Eighty-five patients were identified. There was a statistically significant increase in the use of daily acid suppression in patients without pouchitis. There was also a statistically significant increase in the use of antacids in patients without pouchitis. Occasional use of acid suppression did not alter the rate of pouchitis.

Conclusions

Our data suggest that the daily use of proton pump inhibitors, H₂ antagonists, or antacids is associated with a decreased risk of pouchitis in ulcerative colitis. Occasional use of these agents did not seem to afford the same protection. These data suggest that altering the pH of the gastrointestinal tract may influence the development of pouchitis.

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Title: Chronic Use of PPI and H2 Antagonists Decreases the Risk of Pouchitis After IPAA for Ulcerative Colitis
Authors: Lisa S. Poritz
Rishabh Sehgal
Arthur S. Berg
Lacee Laufenberg
Christine Choi
Emmanuelle D. Williams
Publication date: 01-06-2013
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 6/2013
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-013-2172-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Chronic Use of PPI and H₂ Antagonists Decreases the Risk of Pouchitis After IPAA for Ulcerative Colitis

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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