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20-11-2023 | Chronic Pancreatitis | Original Article

Pregnancy Outcomes in Patients with Early-Onset Idiopathic Chronic Pancreatitis

Authors: Gauri Kumbhar, Sudipta Dhar Chowdhury, Santosh Benjamin, Reuben Thomas Kurien, Ajith Thomas, Amit Dutta, Ebby George Simon, A. J. Joseph

Published in: Digestive Diseases and Sciences | Issue 1/2024

Abstract

Background

Early-onset idiopathic chronic pancreatitis (EOICP) is a disease that affects young individuals. Data on pregnancy outcomes in EOICP are limited.

Aim

To assess the pregnancy outcomes in patients with EOICP and the effect of pregnancy on the course of EOICP.

Methods

Patients with EOICP with disease onset before their pregnancy were recruited. Data regarding demographic variables, disease duration, pregnancy outcomes, and course of illness were noted.

Results

50 patients were included in the study contributing to a total of 86 pregnancies. The mean age of onset of symptoms and at the time of delivery was 17.95 (5.71) and 23.44 (4.28) years, respectively. Gestational diabetes (GD) and gestational hypertension (GH) noted in one (1.5%) each. 3 (4.5%) pregnancies were preterm. 19 (22.1%) pregnancies did not have successful outcomes (7 (8.1%) were induced abortions). 12 (15.2%) pregnancies had spontaneous pregnancy losses. 8 (10.1%) were spontaneous abortions and 4 (5.1%) were stillbirths. Of 67 successful pregnancies, 33 (49.3%) pregnancies were delivered by LSCS. Compared to average rates of LSCS in India, this was significantly higher (21.5% vs 49.3%—p ≤ 0.001). The average birth weight was 2.87 (0.48) kg. There was one (1.5%) neonatal death. Compared to the published Indian data, there was no significant difference in the incidence of spontaneous pregnancy losses, GD, GH, preterm labor, and birth weight.

Pancreatic pain was reported by 21 (42%) women in total 27 (31.4%) pregnancies. There was no difference in maternal or fetal outcomes between pregnancies with or without pancreatic pain. There were no pancreatitis-related complications reported during the pregnancies.

Conclusion

The present study shows that mothers affected with EOICP have pregnancy outcomes similar to healthy women in India.

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Title: Pregnancy Outcomes in Patients with Early-Onset Idiopathic Chronic Pancreatitis
Authors: Gauri Kumbhar
Sudipta Dhar Chowdhury
Santosh Benjamin
Reuben Thomas Kurien
Ajith Thomas
Amit Dutta
Ebby George Simon
A. J. Joseph
Publication date: 20-11-2023
Publisher: Springer US
Keywords: Chronic Pancreatitis
Gestational Diabetes
Gestational Diabetes
Pancreatogenic Diabetes
Pancreatitis
Preterm Labor
Published in: Digestive Diseases and Sciences / Issue 1/2024
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-023-08174-y

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