Skip to main content
Top
Published in: Journal of Nephrology 2/2024

16-01-2024 | Chronic Kidney Disease | Original Article

General practitioners’ representation of early-stage CKD is a barrier to adequate management and patient empowerment: a phenomenological study

Authors: Agnès Oude Engberink, Guillaume Tessier, Ilham Kamil, Gérard Bourrel, Olivier Moranne

Published in: Journal of Nephrology | Issue 2/2024

Login to get access

Abstract

Background

In high-income countries, chronic kidney disease (CKD) affects over 10% of the population. Identifying these patients early is a priority, especially as new treatments are available to reduce the risk of cardiovascular and renal morbidity. We aimed at understanding the management and care pathway of patients with early-to-moderate CKD defined as an estimated glomerular filtration rate (eGFR) ≥ 45 mL/min/1.73 m2 (CKD-EPI), by analyzing the experience of general practitioners in a region in France.

Methods

This qualitative semiopragmatic phenomenological study analyzed in-depth interviews held with a purposive sample (age, gender, training, type of practice, rural/urban context) of 24 general practitioners, with triangulation of research until data saturation.

Results

From diagnostic, etiological and prognostic viewpoints, the general practitioners enrolled in our study perceived CKD as a complex, poorly-defined clinical entity in asymptomatic and multimorbid patients. They distinguished it from a rare condition they considered as ‘mainly renal’. The fact that they did not perceive early-stage CKD as a disease was a hindrance to patient care, which should protect the kidneys with a preventive approach. Indeed, general practitioners perceived CKD patient management as a pathway requiring a personalized, integrative model, common to all chronic diseases, without necessarily involving a nephrologist, at least in the early stages.

Conclusions

This study shows how the general practitioners’ representations influence their attitudes and interventions. Clarifying the concept of early-stage CKD by taking factors like age and etiology into account would facilitate personalized management of this heterogeneous, often multimorbid, population. Finally, organizational models to support patient empowerment in an integrative care pathway must be established and validated.

Graphical abstract

Appendix
Available only for authorised users
Literature
1.
go back to reference Elliott MJ, Gil S, Hemmelgarn BR et al (2017) A scoping review of adult chronic kidney disease clinical pathways for primary care. Nephrol Dial Transplant 32:838–846PubMed Elliott MJ, Gil S, Hemmelgarn BR et al (2017) A scoping review of adult chronic kidney disease clinical pathways for primary care. Nephrol Dial Transplant 32:838–846PubMed
2.
go back to reference Couser WG, Remuzzi G, Mendis S, Tonelli M (2011) The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int 80:1258–1270CrossRefPubMed Couser WG, Remuzzi G, Mendis S, Tonelli M (2011) The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int 80:1258–1270CrossRefPubMed
3.
go back to reference Matsushita K, Coresh J, Sang Y et al (2015) Kidney measures beyond traditional risk factors for cardiovascular prediction: a collaborative meta-analysis. Lancet Diabetes Endocrinol 3:514–525CrossRefPubMedPubMedCentral Matsushita K, Coresh J, Sang Y et al (2015) Kidney measures beyond traditional risk factors for cardiovascular prediction: a collaborative meta-analysis. Lancet Diabetes Endocrinol 3:514–525CrossRefPubMedPubMedCentral
4.
go back to reference Meraz-Muñoz AY, Weinstein J, Wald R (2021) eGFR decline after SGLT2 inhibitor initiation: the tortoise and the hare reimagined. Kidney360 2:1042–1047CrossRefPubMedPubMedCentral Meraz-Muñoz AY, Weinstein J, Wald R (2021) eGFR decline after SGLT2 inhibitor initiation: the tortoise and the hare reimagined. Kidney360 2:1042–1047CrossRefPubMedPubMedCentral
5.
go back to reference Legrand K, Speyer E, Stengel B et al (2020) Perceived health and quality of life in patients with CKD, including those with kidney failure: findings from national surveys in France. Am J Kidney Dis 75:868–878CrossRefPubMed Legrand K, Speyer E, Stengel B et al (2020) Perceived health and quality of life in patients with CKD, including those with kidney failure: findings from national surveys in France. Am J Kidney Dis 75:868–878CrossRefPubMed
6.
go back to reference Shlipak MG, Tummalapalli SL, Boulware LE et al (2021) The case for early identification and intervention of chronic kidney disease: conclusions from a kidney disease: improving global outcomes (KDIGO) controversies conference. Kidney Int 99:34–47CrossRefPubMed Shlipak MG, Tummalapalli SL, Boulware LE et al (2021) The case for early identification and intervention of chronic kidney disease: conclusions from a kidney disease: improving global outcomes (KDIGO) controversies conference. Kidney Int 99:34–47CrossRefPubMed
7.
go back to reference Torreggiani M (2022) Referral of patients with chronic kidney disease: inconsistencies between guidelines and real-life practice, more questions than answers. J Nephrol 35:1371–1373CrossRefPubMedPubMedCentral Torreggiani M (2022) Referral of patients with chronic kidney disease: inconsistencies between guidelines and real-life practice, more questions than answers. J Nephrol 35:1371–1373CrossRefPubMedPubMedCentral
8.
go back to reference Levin A, Stevens P, Bilous RW et al (2013) Kidney disease: Improving global outcomes (KDIGO) CKD work group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 3:1–150 Levin A, Stevens P, Bilous RW et al (2013) Kidney disease: Improving global outcomes (KDIGO) CKD work group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 3:1–150
9.
go back to reference Tonelli M, Dickinson JA (2020) Early detection of CKD: implications for low-income, middle-income, and high-income countries. J Am Soc Nephrol 31:1931–1940CrossRefPubMedPubMedCentral Tonelli M, Dickinson JA (2020) Early detection of CKD: implications for low-income, middle-income, and high-income countries. J Am Soc Nephrol 31:1931–1940CrossRefPubMedPubMedCentral
10.
go back to reference Tonelli M, Wiebe N, Manns BJ et al (2018) Comparison of the complexity of patients seen by different medical subspecialists in a universal health care system. JAMA Netw Open 1:e184852CrossRefPubMedPubMedCentral Tonelli M, Wiebe N, Manns BJ et al (2018) Comparison of the complexity of patients seen by different medical subspecialists in a universal health care system. JAMA Netw Open 1:e184852CrossRefPubMedPubMedCentral
11.
go back to reference HAS 2021 Synthèse, MRC de l’adulte: les points critiques du parcours. Document de travail 23 juin 2021 HAS 2021 Synthèse, MRC de l’adulte: les points critiques du parcours. Document de travail 23 juin 2021
12.
go back to reference Weckmann GFC, Stracke S, Haase A et al (2018) Diagnosis and management of non-dialysis chronic kidney disease in ambulatory care: a systematic review of clinical practice guidelines. BMC Nephrol 19:258CrossRefPubMedPubMedCentral Weckmann GFC, Stracke S, Haase A et al (2018) Diagnosis and management of non-dialysis chronic kidney disease in ambulatory care: a systematic review of clinical practice guidelines. BMC Nephrol 19:258CrossRefPubMedPubMedCentral
13.
go back to reference Llewellyn S (2019) The chronic care model, kidney disease, and primary care: a scoping review. Nephrol Nurs J 46:301–328PubMed Llewellyn S (2019) The chronic care model, kidney disease, and primary care: a scoping review. Nephrol Nurs J 46:301–328PubMed
14.
go back to reference Greer RC, Liu Y, Cavanaugh K et al (2019) Primary care physicians’ perceived barriers to nephrology referral and co-management of patients with CKD: a qualitative study. J Gen Intern Med 34:1228–1235CrossRefPubMedPubMedCentral Greer RC, Liu Y, Cavanaugh K et al (2019) Primary care physicians’ perceived barriers to nephrology referral and co-management of patients with CKD: a qualitative study. J Gen Intern Med 34:1228–1235CrossRefPubMedPubMedCentral
15.
go back to reference Schulz C, Messikh Z, Reboul P et al (2022) Characteristics of outpatients referred for a first consultation with a nephrologist: impact of different guidelines. J Nephrol 35:1375–1385CrossRefPubMed Schulz C, Messikh Z, Reboul P et al (2022) Characteristics of outpatients referred for a first consultation with a nephrologist: impact of different guidelines. J Nephrol 35:1375–1385CrossRefPubMed
16.
go back to reference van Dipten C, van Berkel S, van Gelder VA et al (2017) Adherence to chronic kidney disease guidelines in primary care patients is associated with comorbidity. Fam Pract 34:459–466CrossRefPubMed van Dipten C, van Berkel S, van Gelder VA et al (2017) Adherence to chronic kidney disease guidelines in primary care patients is associated with comorbidity. Fam Pract 34:459–466CrossRefPubMed
17.
go back to reference van Dipten C, van Berkel S, de Grauw WJC et al (2018) General practitioners’ perspectives on management of early-stage chronic kidney disease: a focus group study. BMC Fam Pract 19:81CrossRefPubMedPubMedCentral van Dipten C, van Berkel S, de Grauw WJC et al (2018) General practitioners’ perspectives on management of early-stage chronic kidney disease: a focus group study. BMC Fam Pract 19:81CrossRefPubMedPubMedCentral
18.
go back to reference Sperati CJ, Soman S, Agrawal V et al (2019) Primary care physicians’ perceptions of barriers and facilitators to management of chronic kidney disease: a mixed methods study. PLoS ONE 14:e0221325CrossRefPubMedPubMedCentral Sperati CJ, Soman S, Agrawal V et al (2019) Primary care physicians’ perceptions of barriers and facilitators to management of chronic kidney disease: a mixed methods study. PLoS ONE 14:e0221325CrossRefPubMedPubMedCentral
19.
go back to reference Neale EP, Middleton J, Lambert K (2020) Barriers and enablers to detection and management of chronic kidney disease in primary healthcare: a systematic review. BMC Nephrol 21:83CrossRefPubMedPubMedCentral Neale EP, Middleton J, Lambert K (2020) Barriers and enablers to detection and management of chronic kidney disease in primary healthcare: a systematic review. BMC Nephrol 21:83CrossRefPubMedPubMedCentral
20.
go back to reference Fracso D, Bourrel G, Jorgensen C et al (2022) The chronic disease Self-Management Programme: a phenomenological study for empowering vulnerable patients with chronic diseases included in the EFFICHRONIC project. Health Expect 25:947–958CrossRefPubMedPubMedCentral Fracso D, Bourrel G, Jorgensen C et al (2022) The chronic disease Self-Management Programme: a phenomenological study for empowering vulnerable patients with chronic diseases included in the EFFICHRONIC project. Health Expect 25:947–958CrossRefPubMedPubMedCentral
21.
go back to reference Tong A, Sainsbury P, Craig J (2007) Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care 19:349–357CrossRefPubMed Tong A, Sainsbury P, Craig J (2007) Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care 19:349–357CrossRefPubMed
22.
go back to reference Palinkas LA, Horwitz SM, Green CA et al (2015) Purposeful sampling for qualitative data collection and analysis in mixed method implementation research. Adm Policy Ment Health 42:533–544CrossRefPubMedPubMedCentral Palinkas LA, Horwitz SM, Green CA et al (2015) Purposeful sampling for qualitative data collection and analysis in mixed method implementation research. Adm Policy Ment Health 42:533–544CrossRefPubMedPubMedCentral
23.
go back to reference Peirce CS (1935) Pragmatism and pragmaticism and scientific metaphysics. In: Weiss P (ed) Hartshorne C. Belknap Press: : An Imprint of Harvard University Press, Boston Peirce CS (1935) Pragmatism and pragmaticism and scientific metaphysics. In: Weiss P (ed) Hartshorne C. Belknap Press: : An Imprint of Harvard University Press, Boston
24.
go back to reference Glaser BG, Strauss AL (1967) The discovery of grounded theory: strategies for qualitative research. Aldine Transaction, Chicago Glaser BG, Strauss AL (1967) The discovery of grounded theory: strategies for qualitative research. Aldine Transaction, Chicago
25.
go back to reference Oliva-Damaso N, Delanaye P, Oliva-Damaso E et al (2022) Risk-based versus GFR threshold criteria for nephrology referral in chronic kidney disease. Clin Kidney J 15:1996–2005CrossRefPubMedPubMedCentral Oliva-Damaso N, Delanaye P, Oliva-Damaso E et al (2022) Risk-based versus GFR threshold criteria for nephrology referral in chronic kidney disease. Clin Kidney J 15:1996–2005CrossRefPubMedPubMedCentral
26.
go back to reference Tiu H, Fagerlin A, Roney M et al (2018) Provider perspectives on chronic kidney disease diagnosis delivery. Clin Nephrol 89:205–213CrossRefPubMed Tiu H, Fagerlin A, Roney M et al (2018) Provider perspectives on chronic kidney disease diagnosis delivery. Clin Nephrol 89:205–213CrossRefPubMed
27.
go back to reference Chu CD, Powe NR, Shlipak MG et al (2022) Albuminuria testing and nephrology care among insured US adults with chronic kidney disease: a missed opportunity. BMC Prim Care 23:299CrossRefPubMedPubMedCentral Chu CD, Powe NR, Shlipak MG et al (2022) Albuminuria testing and nephrology care among insured US adults with chronic kidney disease: a missed opportunity. BMC Prim Care 23:299CrossRefPubMedPubMedCentral
28.
go back to reference James G, Garcia Sanchez JJ, Carrero JJ et al (2022) Low adherence to kidney disease: improving global outcomes 2012 CKD clinical practice guidelines despite clear evidence of utility. Kidney Int Rep 7:2059–2070CrossRefPubMedPubMedCentral James G, Garcia Sanchez JJ, Carrero JJ et al (2022) Low adherence to kidney disease: improving global outcomes 2012 CKD clinical practice guidelines despite clear evidence of utility. Kidney Int Rep 7:2059–2070CrossRefPubMedPubMedCentral
29.
go back to reference Weckmann G, Wirkner J, Kasbohm E et al (2022) Monitoring and management of chronic kidney disease in ambulatory care—nalysis of clinical and claims data from a population-based study. BMC Health Serv Res 22:1330CrossRefPubMedPubMedCentral Weckmann G, Wirkner J, Kasbohm E et al (2022) Monitoring and management of chronic kidney disease in ambulatory care—nalysis of clinical and claims data from a population-based study. BMC Health Serv Res 22:1330CrossRefPubMedPubMedCentral
30.
go back to reference Litvin CB, Nietert PJ, Jenkins RG et al (2020) Translating CKD research into primary care practice: a group-randomized study. J Gen Intern Med 35:1435–1443CrossRefPubMed Litvin CB, Nietert PJ, Jenkins RG et al (2020) Translating CKD research into primary care practice: a group-randomized study. J Gen Intern Med 35:1435–1443CrossRefPubMed
31.
go back to reference Van den Bulck SA, Vankrunkelsven P, Goderis G et al (2020) Developing quality indicators for chronic kidney disease in primary care, extractable from the electronic medical record. A Rand-modified Delphi method. BMC Nephrol 21:161CrossRefPubMedPubMedCentral Van den Bulck SA, Vankrunkelsven P, Goderis G et al (2020) Developing quality indicators for chronic kidney disease in primary care, extractable from the electronic medical record. A Rand-modified Delphi method. BMC Nephrol 21:161CrossRefPubMedPubMedCentral
33.
go back to reference Mok Y, Ballew SH, Stacey RB et al (2021) Albuminuria and prognosis among individuals with atherosclerotic cardiovascular disease: the ARIC study. J Am Coll Cardiol 78:87–89CrossRefPubMed Mok Y, Ballew SH, Stacey RB et al (2021) Albuminuria and prognosis among individuals with atherosclerotic cardiovascular disease: the ARIC study. J Am Coll Cardiol 78:87–89CrossRefPubMed
34.
go back to reference Ghimire A, Ye F, Hemmelgarn B et al (2022) Trends in nephrology referral patterns for patients with chronic kidney disease: retrospective cohort study. PLoS ONE 17:e0272689CrossRefPubMedPubMedCentral Ghimire A, Ye F, Hemmelgarn B et al (2022) Trends in nephrology referral patterns for patients with chronic kidney disease: retrospective cohort study. PLoS ONE 17:e0272689CrossRefPubMedPubMedCentral
35.
go back to reference Vassalotti JA, Boucree SC (2022) Integrating CKD into US primary care: bridging the knowledge and implementation gaps. Kidney International Reports 7:389–396CrossRefPubMedPubMedCentral Vassalotti JA, Boucree SC (2022) Integrating CKD into US primary care: bridging the knowledge and implementation gaps. Kidney International Reports 7:389–396CrossRefPubMedPubMedCentral
36.
go back to reference Smith ZG, McNicoll L, Clark TL et al (2016) Medical neighborhood model for the care of chronic kidney disease patients. Am J Nephrol 44:308–315CrossRefPubMed Smith ZG, McNicoll L, Clark TL et al (2016) Medical neighborhood model for the care of chronic kidney disease patients. Am J Nephrol 44:308–315CrossRefPubMed
37.
go back to reference Pesce F, Pasculli D, Pasculli G et al (2022) “The disease awareness innovation network” for chronic kidney disease identification in general practice. J Nephrol 35:2057–2065CrossRefPubMedPubMedCentral Pesce F, Pasculli D, Pasculli G et al (2022) “The disease awareness innovation network” for chronic kidney disease identification in general practice. J Nephrol 35:2057–2065CrossRefPubMedPubMedCentral
38.
go back to reference Taylor DM, Nimmo AM, Caskey FJ et al (2023) Complex interventions across primary and secondary care to optimize population kidney health: a systematic review and realist synthesis to understand contexts, mechanisms, and outcomes. Clin J Am Soc Nephrol 18:563–572CrossRefPubMed Taylor DM, Nimmo AM, Caskey FJ et al (2023) Complex interventions across primary and secondary care to optimize population kidney health: a systematic review and realist synthesis to understand contexts, mechanisms, and outcomes. Clin J Am Soc Nephrol 18:563–572CrossRefPubMed
Metadata
Title
General practitioners’ representation of early-stage CKD is a barrier to adequate management and patient empowerment: a phenomenological study
Authors
Agnès Oude Engberink
Guillaume Tessier
Ilham Kamil
Gérard Bourrel
Olivier Moranne
Publication date
16-01-2024
Publisher
Springer International Publishing
Published in
Journal of Nephrology / Issue 2/2024
Print ISSN: 1121-8428
Electronic ISSN: 1724-6059
DOI
https://doi.org/10.1007/s40620-023-01838-y

Other articles of this Issue 2/2024

Journal of Nephrology 2/2024 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine