Top

Open Access 11-05-2024 | Chronic Inflammatory Bowel Disease | Review Article

Physical activity in the prevention and management of inflammatory bowel disease: a systematic review

Authors: Carmela Protano, Francesca Gallè, Veronica Volpini, Andrea De Giorgi, Elisa Mazzeo, Francesca Ubaldi, Vincenzo Romano Spica, Matteo Vitali, Federica Valeriani

Published in: Journal of Public Health

Abstract

Aim

This study aimed to assess the potential role of physical activity (PA) in reducing the risk of developing inflammatory bowel diseases (IBDs) and in their management.

Subject and methods

A systematic review of literature was conducted up to October 2023 using the PubMed, Scopus, Web of Science and Cochrane Library databases. Observational studies, semi-experimental and experimental studies reporting PA effects were considered eligible. Data on disease status and PA characteristics, main outcomes and possible confounders were collected in a database. The Newcastle–Ottawa Quality Assessment Scale was used to assess risk of bias.

Results

Of the 29 articles included, six investigated PA and risk of IBDs and four of them showed an inverse relationship. Among the others, seven reported positive effects of PA on IBD symptoms, while all showed improvements in comorbidities, complications and quality of life.

Conclusion

PA seems to be effective in preventing or treating IBDs and their complications. Owing to the low quality of the majority of the studies and their heterogeneity, further research is needed to better understand which type and level of PA may be useful in the prevention and treatment of these diseases.

Anderson E, Durstine JL (2019) Physical activity, exercise, and chronic diseases: a brief review. Sports Med Health Sci 1(1):3–10. https://doi.org/10.1016/j.smhs.2019.08.006CrossRefPubMedPubMedCentral

Axelrad JE, Olén O, Askling J, Lebwohl B, Khalili H, Sachs MC, Ludvigsson JF (2019) Gastrointestinal infection increases odds of inflammatory bowel disease in a nationwide case-control study. Clin Gastroenterol Hepatol: Off Clin Pract J Am Gastroenterol Assoc 17(7):311-1322.e7. https://doi.org/10.1016/j.cgh.2018.09.034CrossRef

Burisch J, Jess T, Martinato M, Lakatos PL, ECCO -EpiCom, (2013) The burden of inflammatory bowel disease in Europe. J Crohn’s Colitis 7(4):322–337. https://doi.org/10.1016/j.crohns.2013.01.010CrossRef

Carnethon MR (2009) Physical activity and cardiovascular disease: how much is enough? Am J Lifestyle Med 3(1):44S-49S. https://doi.org/10.1177/1559827609332737CrossRefPubMed

Caviglia GP, Rosso C, Stalla F, Rizzo M, Massano A, Abate ML, Olivero A, Armandi A, Vanni E, Younes R, Fagoonee S, Pellicano R, Astegiano M, Saracco GM, Bugianesi E, Ribaldone DG (2020) On-treatment decrease of serum interleukin-6 as a predictor of clinical response to biologic therapy in patients with inflammatory bowel diseases. J Clin Med 9(3):800. https://doi.org/10.3390/jcm9030800CrossRefPubMedPubMedCentral

Caviglia GP, Garrone A, Bertolino C, Vanni R, Bretto E, Poshnjari A, Tribocco E, Frara S, Armandi A, Astegiano M, Saracco GM, Bertolusso L, Ribaldone DG (2023) Epidemiology of inflammatory bowel diseases: a population study in a healthcare district of North-West Italy. J Clin Med 12(2):641. https://doi.org/10.3390/jcm12020641CrossRefPubMedPubMedCentral

Coates MD, Dalessio S, Walter V, Stuart A, Tinsley A, Williams ED, Clarke K (2023) Lifestyle factors associated with abdominal pain in quiescent inflammatory bowel disease. Dig Dis Sci 68(11):4156–4165. https://doi.org/10.1007/s10620-023-08075-0CrossRefPubMed

Coward S, Clement F, Benchimol EI, Bernstein CN, Avina-Zubieta JA, Bitton A, Carroll MW, Hazlewood G, Jacobson K, Jelinski S, Deardon R, Jones JL, Kuenzig ME, Leddin D, McBrien KA, Murthy SK, Nguyen GC, Otley AR, Panaccione R, Rezaie A, Kaplan GG (2019) Past and future burden of inflammatory bowel diseases based on modeling of population-based data. Gastroenterology 156(5):1345-1353.e4. https://doi.org/10.1053/j.gastro.2019.01.002CrossRefPubMed

Cronin O, Barton W, Moran C, Sheehan D, Whiston R, Nugent H, McCarthy Y, Molloy CB, O’Sullivan O, Cotter PD, Molloy MG, Shanahan F (2019) Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory bowel disease: a randomized controlled cross-over trial. BMC Gastroenterol 19(1):29. https://doi.org/10.1186/s12876-019-0952-xCrossRefPubMedPubMedCentral

DeFilippis EM, Tabani S, Warren RU, Christos PJ, Bosworth BP, Scherl EJ (2016) Exercise and self-reported limitations in patients with inflammatory bowel disease. Dig Dis Sci 61(1):215–220. https://doi.org/10.1007/s10620-015-3832-4CrossRefPubMed

D’Incà R, Varnier M, Mestriner C, Martines D, D’Odorico A, Sturniolo GC (1999) Effect of moderate exercise on Crohn’s disease patients in remission. Ital J Gastroenterol Hepatol 31(3):205–210PubMed

Dorelli B, Gallè F, De Vito C, Duranti G, Iachini M, Zaccarin M, Preziosi Standoli J, Ceci R, Romano F, Liguori G, Romano Spica V, Sabatini S, Valeriani F, Cattaruzza MS (2021) Can physical activity influence human gut microbiota composition independently of diet? Syst Rev Nutri 13(6):1890. https://doi.org/10.3390/nu13061890CrossRef

Elsenbruch S, Langhorst J, Popkirowa K, Müller T, Luedtke R, Franken U, Paul A, Spahn G, Michalsen A, Janssen OE, Schedlowski M, Dobos GJ (2005) Effects of mind-body therapy on quality of life and neuroendocrine and cellular immune functions in patients with ulcerative colitis. Psychother Psychosom 74(5):277–287. https://doi.org/10.1159/000086318CrossRefPubMed

Furuya Y, Fukai K, Nakazawa S, Kojimahara N, Hoshi K, Toyota A, Tatemichi M (2022) Occupational physical activity differentially affects the risk for developing later-onset Crohn’s disease and ulcerative colitis among middle-aged and older populations. Scand J Gastroenterol 57(2):206–213. https://doi.org/10.1080/00365521.2021.1999495CrossRefPubMed

Gallè F, Valeriani F, Cattaruzza MS, Gianfranceschi G, Liguori R, Antinozzi M, Mederer B, Liguori G, Romano Spica V (2020) Mediterranean diet, physical activity and gut microbiome composition: a cross-sectional study among healthy young Italian adults. Nutrients 12(7):2164. https://doi.org/10.3390/nu12072164CrossRefPubMedPubMedCentral

Gatt K, Schembri J, Katsanos KH, Christodoulou D, Karmiris K, Kopylov U, Pontas C, Koutroubakis IE, Foteinogiannopoulou K, Fabian A, Molnar T, Zammit D, Fragaki M, Balomenos D, Zingboim N, Ben Horin S, Mantzaris GJ, Ellul P (2019) Inflammatory Bowel Disease [IBD] and physical activity: a study on the impact of diagnosis on the level of exercise amongst patients With IBD. J Crohns Colitis 13(6):686–692. https://doi.org/10.1093/ecco-jcc/jjy214CrossRefPubMed

Gohil K, Carramusa B (2014) Ulcerative colitis and Crohn’s disease. P & t: A Peer-Rev J Formul Manag 39(8):576–577

Hammer T, Langholz E (2020) The epidemiology of inflammatory bowel disease: balance between East and West? A narrative review. Digest Med Res 3. https://doi.org/10.21037/dmr-20-149

Henderson B, Meurs J, Lamers CR, Batista GL, Materić D, Bertinetto CG, Bongers CCWG, Holzinger R, Harren FJM, Jansen JJ, Hopman MTE, Cristescu SM (2022) Non-invasive monitoring of inflammation in inflammatory bowel disease patients during prolonged exercise via exhaled breath volatile organic compounds. Metabolites 12(3):224. https://doi.org/10.3390/metabo12030224CrossRefPubMedPubMedCentral

Hlavaty T, Toth J, Koller T, Krajcovicova A, Oravcova S, Zelinkova Z, Huorka M (2013) Smoking, breastfeeding, physical inactivity, contact with animals, and size of the family influence the risk of inflammatory bowel disease: a Slovak case-control study. United Eur Gastroenterol J 1(2):109–119. https://doi.org/10.1177/2050640613478011CrossRef

Holik D, Včev A, Milostić-Srb A, Salinger Ž, Ivanišević Z, Včev I, Miškulin M (2019) The effect of daily physical activity on the activity of inflammatory bowel diseases in therapy-free patients. Acta Clinica Croatica 58(2):202–212. https://doi.org/10.20471/acc.2019.58.02.02

Huang Y, Chen Z (2016) Inflammatory bowel disease related innate immunity and adaptive immunity. Am J Transl Res 8(6):2490–2497

Imbrizi M, Magro F, Coy CSR (2023) Pharmacological therapy in inflammatory bowel diseases: a narrative review of the past 90 years. Pharmaceuticals (basel, Switzerland) 16(9):1272. https://doi.org/10.3390/ph16091272CrossRefPubMed

Jaiswal V, Batra N, Dagar M, Butey S, Huang H, Chia JE, Naz S, Endurance EO, Raj N, Patel S, Maroo D, Ang SP, Hanif M, Mukherjee D, Sarfraz Z, Shrestha AB, Song D (2023) Inflammatory bowel disease and associated cardiovascular disease outcomes: a systematic review. Medicine 102(6):e32775. https://doi.org/10.1097/MD.0000000000032775CrossRefPubMedPubMedCentral

Jones PD, Kappelman MD, Martin CF, Chen W, Sandler RS, Long MD (2015) Exercise decreases risk of future active disease in patients with inflammatory bowel disease in remission. Inflamm Bowel Dis 21(5):1063–1071. https://doi.org/10.1097/MIB.0000000000000333CrossRefPubMed

Jones K, Baker K, Speight RA, Thompson NP, Tew GA (2020) Randomised clinical trial: combined impact and resistance training in adults with stable Crohn’s disease. Aliment Pharmacol Ther 52(6):964–975. https://doi.org/10.1111/apt.16002CrossRefPubMed

Kaplan GG (2015) The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol 12(12):720–727. https://doi.org/10.1038/nrgastro.2015.150CrossRefPubMed

Kaplan GG, Windsor JW (2021) The four epidemiological stages in the global evolution of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol 18(1):56–66. https://doi.org/10.1038/s41575-020-00360-xCrossRefPubMed

Khalili H, Huang ES, Ananthakrishnan AN, Higuchi L, Richter JM, Fuchs CS, Chan AT (2012) Geographical variation and incidence of inflammatory bowel disease among US women. Gut 61(12):1686–1692. https://doi.org/10.1136/gutjnl-2011-301574CrossRefPubMed

Khalili H, Ananthakrishnan AN, Konijeti GG, Liao X, Higuchi LM, Fuchs CS, Spiegelman D, Richter JM, Korzenik JR, Chan AT (2013) Physical activity and risk of inflammatory bowel disease: prospective study from the Nurses’ Health Study cohorts. BMJ (clinical Research Ed) 347:f6633. https://doi.org/10.1136/bmj.f6633CrossRefPubMed

Kim B, Chae J, Kim EH, Yang HI, Cheon JH, Kim TI, Kim WH, Jeon JY, Park SJ (2021) Physical activity and quality of life of patients with inflammatory bowel disease. Medicine 100(27):e26290. https://doi.org/10.1097/MD.0000000000026290CrossRefPubMedPubMedCentral

Klare P, Nigg J, Nold J, Haller B, Krug AB, Mair S, Thoeringer CK, Christle JW, Schmid RM, Halle M, Huber W (2015) The impact of a ten-week physical exercise program on health-related quality of life in patients with inflammatory bowel disease: a prospective randomized controlled trial. Digestion 91(3):239–247. https://doi.org/10.1159/000371795CrossRefPubMed

Klein I, Reif S, Farbstein H, Halak A, Gilat T (1998) Preillness non dietary factors and habits in inflammatory bowel disease. Ital J Gastroenterol Hepatol 30(3):247–251PubMed

Kuenzig ME, Manuel DG, Donelle J, Benchimol EI (2020) Life expectancy and health-adjusted life expectancy in people with inflammatory bowel disease. CMAJ: Can Med Assoc J 192(45):E1394-E1402. https://doi.org/10.1503/cmaj.190976

Kugathasan S, Nebel J, Skelton JA, Markowitz J, Keljo D, Rosh J, LeLeiko N, Mack D, Griffiths A, Bousvaros A, Evans J, Mezoff A, Moyer S, Oliva-Hemker M, Otley A, Pfefferkorn M, Crandall W, Wyllie R, Hyams J, Wisconsin Pediatric Inflammatory Bowel Disease Alliance, Pediatric Inflammatory Bowel Disease Collaborative Research Group (2007) Body mass index in children with newly diagnosed inflammatory bowel disease: observations from two multicenter North American inception cohorts. J Pediats 151(5):523-527https://doi.org/10.1016/j.jpeds.2007.04.004

Lamers CR, de Roos NM, Bongers CCWG, Ten Haaf DSM, Hartman YAW, Witteman BJM, Hopman MTE (2021a) Repeated prolonged moderate-intensity walking exercise does not appear to have harmful effects on inflammatory markers in patients with inflammatory bowel disease. Scand J Gastroenterol 56(1):30–37. https://doi.org/10.1080/00365521.2020.1845791CrossRefPubMed

Lamers CR, de Roos NM, Koppelman LJM, Hopman MTE, Witteman BJM (2021b) Patient experiences with the role of physical activity in inflammatory bowel disease: results from a survey and interviews. BMC Gastroenterol 21(1):172. https://doi.org/10.1186/s12876-021-01739-zCrossRefPubMedPubMedCentral

Lamers CR, de Roos NM, Heerink HH, van de Worp-Kalter LA, Witteman BJM (2022) Lower impact of disease on daily life and less fatigue in patients with inflammatory bowel disease following a lifestyle intervention. Inflamm Bowel Dis 28(12):1791–1799. https://doi.org/10.1093/ibd/izac027CrossRefPubMedPubMedCentral

Lautenschlager SA, Barry MP, Rogler G, Biedermann L, Schreiner P, Siebenhüner AR, Swiss IBD Cohort Study Group (2023) Lifestyle factors associated with inflammatory bowel disease: data from the Swiss IBD cohort study. BMC Gastroenterol 23(1):71.https://doi.org/10.1186/s12876-023-02692-9

Lee N, Radford-Smith G, Taaffe DR (2005) Bone loss in Crohn’s disease: exercise as a potential countermeasure. Inflamm Bowel Dis 11(12):1108–1118. https://doi.org/10.1097/01.mib.0000192325.28168.08CrossRefPubMed

Lo CH, Khalili H, Song M, Lochhead P, Burke KE, Richter JM, Giovannucci EL, Chan AT, Ananthakrishnan AN (2021) Healthy lifestyle is associated with reduced mortality in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol: Off Clin Pract J Am Gastroenterol Assoc 19(1):87–95. https://doi.org/10.1016/j.cgh.2020.02.047CrossRef

Mack DE, Wilson PM, Gilmore JC, Gunnell KE (2011) Leisure-time physical activity in Canadians living with Crohn disease and ulcerative colitis: population-based estimates. Gastroenterol Nurs: Off J Soc Gastroenterol Nurses Associat 34(4):288–294. https://doi.org/10.1097/SGA.0b013e3182248732CrossRef

Molodecky NA, Soon IS, Rabi DM, Ghali WA, Ferris M, Chernoff G, Benchimol EI, Panaccione R, Ghosh S, Barkema HW, Kaplan GG (2012) Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 142(1):46-e30. https://doi.org/10.1053/j.gastro.2011.10.001CrossRefPubMed

Ng V, Millard W, Lebrun C, Howard J (2007) Low-intensity exercise improves quality of life in patients with Crohn’s disease. Clin J Sport Med: Off J Can Acad Sport Med 17(5):384–388. https://doi.org/10.1097/JSM.0b013e31802b4fdaCrossRef

Nishida Y, Hosomi S, Kobayashi Y, Nakata R, Ominami M, Nadatani Y, Fukunaga S, Otani K, Tanaka F, Nagami Y, Taira K, Kamata N, Fujiwara Y (2023) Impact of the COVID-19 pandemic on the lifestyle and psychosocial behavior of patients with inflammatory bowel diseases: a narrative review. Healthcare (basel, Switzerland) 11(19):2642. https://doi.org/10.3390/healthcare11192642CrossRefPubMed

O’Reilly C, Mills S, Rea MC, Lavelle A, Ghosh S, Hill C, Ross RP (2023) Interplay between inflammatory bowel disease therapeutics and the gut microbiome reveals opportunities for novel treatment approaches. Microbiome Res Rep 2(4):35. https://doi.org/10.20517/mrr.2023.41

Ordille AJ, Phadtare S (2023) Intensity-specific considerations for exercise for patients with inflammatory bowel disease. Gastroenterol Report 11:goad004. https://doi.org/10.1093/gastro/goad004

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (clinical Research Ed) 372:71. https://doi.org/10.1136/bmj.n71CrossRef

Parigi TL, D’Amico F, Abreu MT, Dignass A, Dotan I, Magro F, Griffiths AM, Jairath V, Iacucci M, Mantzaris GJ, O’Morain C, Reinisch W, Sachar DB, Turner D, Yamamoto T, Rubin DT, Peyrin-Biroulet L, Ghosh S, Danese S (2023) Difficult-to-treat inflammatory bowel disease: results from an international consensus meeting. Lancet Gastroenterol Hepatol 8(9):853–859. https://doi.org/10.1016/S2468-1253(23)00154-1CrossRefPubMed

Rasmussen NF, Bech BH, Rubin KH, Andersen V (2021) Associations between participation in, intensity of, and time spent on leisure time physical activity and risk of inflammatory bowel disease among older adults (PA-IBD): a prospective cohort study. BMC Public Health 21(1):634. https://doi.org/10.1186/s12889-021-10492-7CrossRefPubMedPubMedCentral

Ratajczak-Pawłowska AE, Michalak M, Szymczak-Tomczak A, Rychter AM, Zawada A, Skoracka K, Dobrowolska A, Krela-Kaźmierczak I (2023) Physical activity, quality of diet and bone mineral density in patients with inflammatory bowel disease. J Human Nutri Dietetics: Off J British Dietetic Assoc 36(5):1692–1700. https://doi.org/10.1111/jhn.13199CrossRef

Robinson RJ, Krzywicki T, Almond L, al-Azzawi F, Abrams K, Iqbal SJ, Mayberry JF (1998) Effect of a low-impact exercise program on bone mineral density in Crohn’s disease: a randomized controlled trial. Gastroenterology 115(1):36-41.https://doi.org/10.1016/s0016-5085(98)70362-2

Sahu P, Kedia S, Ahuja V, Tandon RK (2021) Diet and nutrition in the management of inflammatory bowel disease. Indian J Gastroenterol: Off J Indian Soc Gastroenterol 40(3):253–264. https://doi.org/10.1007/s12664-021-01163-xCrossRef

Schuch FB, Vancampfort D (2021) Physical activity, exercise, and mental disorders: it is time to move on. Trends in Psychiat Psychother 43(3):177–184. https://doi.org/10.47626/2237-6089-2021-0237

Sharif K, Watad A, Bragazzi NL, Lichtbroun M, Amital H, Shoenfeld Y (2018) Physical activity and autoimmune diseases: get moving and manage the disease. Autoimmun Rev 17(1):53–72. https://doi.org/10.1016/j.autrev.2017.11.010CrossRefPubMed

Spijkerman R, Hesselink L, Bertinetto C, Bongers CCWG, Hietbrink F, Vrisekoop N, Leenen LPH, Hopman MTE, Jansen JJ, Koenderman L (2021) Refractory neutrophils and monocytes in patients with inflammatory bowel disease after repeated bouts of prolonged exercise. Cytometry. part B, clinical cytometry 100(6):676–682. https://doi.org/10.1002/cyto.b.21996

Steensberg A, Toft AD, Bruunsgaard H, Sandmand M, Halkjaer-Kristensen J, Pedersen BK (2001) Strenuous exercise decreases the percentage of type 1 T cells in the circulation. J Appl Physiol (Bethesda, Md.: 1985) 91(4):1708–1712. https://doi.org/10.1152/jappl.2001.91.4.1708

Taylor K, Scruggs PW, Balemba OB, Wiest MM, Vella CA (2018) Associations between physical activity, resilience, and quality of life in people with inflammatory bowel disease. Eur J Appl Physiol 118(4):829–836. https://doi.org/10.1007/s00421-018-3817-zCrossRefPubMed

Tew GA, Jones K, Mikocka-Walus A (2016) Physical activity habits, limitations, and predictors in people with inflammatory bowel disease: a large cross-sectional online survey. Inflamm Bowel Dis 22(12):2933–2942. https://doi.org/10.1097/MIB.0000000000000962CrossRefPubMed

Torres J, Gomes C, Jensen CB, Agrawal M, Ribeiro-Mourão F, Jess T, Colombel JF, Allin KH, Burisch J (2023) Risk factors for developing inflammatory bowel disease within and across families with a family history of IBD. J Crohns Colitis 17(1):30–36. https://doi.org/10.1093/ecco-jcc/jjac111CrossRefPubMed

Ungaro R, Bernstein CN, Gearry R, Hviid A, Kolho KL, Kronman MP, Shaw S, Van Kruiningen H, Colombel JF, Atreja A (2014) Antibiotics associated with increased risk of new-onset Crohn’s disease but not ulcerative colitis: a meta-analysis. Am J Gastroenterol 109(11):1728–1738. https://doi.org/10.1038/ajg.2014.246CrossRefPubMed

Valenzuela PL, Ruilope LM, Santos-Lozano A, Wilhelm M, Kränkel N, Fiuza-Luces C, Lucia A (2023) Exercise benefits in cardiovascular diseases: from mechanisms to clinical implementation. Eur Heart J 44(21):1874–1889. https://doi.org/10.1093/eurheartj/ehad170CrossRefPubMed

Van Der Sloot KW, Joshi AD, Bellavance DR, Gilpin KK, Stewart KO, Lochhead P, Garber JJ, Giallourakis C, Yajnik V, Ananthakrishnan AN, Alizadeh BZ, Xavier RJ, Khalili H (2017) Visceral adiposity, genetic susceptibility, and risk of complications among individuals with Crohn’s disease. Inflamm Bowel Dis 23(1):82–88. https://doi.org/10.1097/MIB.0000000000000978

van Langenberg DR, Gibson PR (2010) Systematic review: fatigue in inflammatory bowel disease. Aliment Pharmacol Ther 32(2):131–143. https://doi.org/10.1111/j.1365-2036.2010.04347.xCrossRefPubMed

Wang R, Li Z, Liu S, Zhang D (2023) Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: a systematic analysis based on the global burden of disease study 2019. BMJ Open 13(3):e065186. https://doi.org/10.1136/bmjopen-2022-065186CrossRefPubMedPubMedCentral

Watanabe J, Furukawa S, Yagi S, Shiraishi K, Hanayama M, Tange K, Hashimoto Y, Kitahata S, Mori K, Ninomiya T, Suzuki S, Shibata N, Murakami H, Ohashi K, Hasebe A, Tomida H, Yamamoto Y, Takeshita E, Ikeda Y, Hiasa Y (2021) Time spent per day in strenuous activity and total physical activity are inversely associated with mucosal healing but not with clinical remission in patients with ulcerative colitis. Ann Gastroenterol 34(6):796–801. https://doi.org/10.20524/aog.2021.0663

Watters C, Wright S, Robinson R, Krzywicki T, Almond L, Shevlin M, Mayberry JF (2001) Positive and negative wellbeing as predictors of exercise uptake in Crohn’s disease: an exploratory study. Psychol Health Med 6(3):293–299. https://doi.org/10.1080/13548500123365CrossRef

Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P (2021) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm. Accessed 7 Feb 2024

Wiestler M, Kockelmann F, Kück M, Kerling A, Tegtbur U, Manns MP, Attaran-Bandarabadi M, Bachmann O (2019) Quality of life is associated with wearable-based physical activity in patients with inflammatory bowel disease: a prospective, observational study. Clin Transl Gastroenterol 10(11):e00094. https://doi.org/10.14309/ctg.0000000000000094

Winer DA, Luck H, Tsai S, Winer S (2016) The Intestinal Immune System in Obesity and Insulin Resistance. Cell Metab 23(3):413–426. https://doi.org/10.1016/j.cmet.2016.01.003CrossRefPubMed

Wojcik-Grzybek D, Hubalewska-Mazgaj M, Surmiak M, Sliwowski Z, Dobrut A, Mlodzinska A, Wojcik A, Kwiecien S, Magierowski M, Mazur-Bialy A, Bilski J, Brzozowski T (2022) The combination of intestinal alkaline phosphatase treatment with moderate physical activity alleviates the severity of experimental colitis in obese mice via modulation of gut microbiota, attenuation of proinflammatory cytokines, oxidative stress biomarkers and DNA oxidative damage in colonic mucosa. Int J Mol Sci 23(6):2964. https://doi.org/10.3390/ijms23062964CrossRefPubMedPubMedCentral

Yeshi K, Ruscher R, Hunter L, Daly NL, Loukas A, Wangchuk P (2020) Revisiting inflammatory bowel disease: pathology, treatments, challenges and emerging therapeutics including drug leads from natural products. J Clin Med 9(5):1273. https://doi.org/10.3390/jcm9051273CrossRefPubMedPubMedCentral

Zhuo C, Zhao J, Chen M, Lu Y (2021) Physical activity and risks of cardiovascular diseases: a mendelian randomization study. Front Cardiovasc Med 8:722154. https://doi.org/10.3389/fcvm.2021.722154CrossRefPubMedPubMedCentral

Title: Physical activity in the prevention and management of inflammatory bowel disease: a systematic review
Authors: Carmela Protano
Francesca Gallè
Veronica Volpini
Andrea De Giorgi
Elisa Mazzeo
Francesca Ubaldi
Vincenzo Romano Spica
Matteo Vitali
Federica Valeriani
Publication date: 11-05-2024
Publisher: Springer Berlin Heidelberg
Keywords: Chronic Inflammatory Bowel Disease
Crohn's Disease
Ulcerative Colitis
Published in: Journal of Public Health
Print ISSN: 2198-1833
Electronic ISSN: 1613-2238
DOI: https://doi.org/10.1007/s10389-024-02278-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Physical activity in the prevention and management of inflammatory bowel disease: a systematic review

Abstract

Aim

Subject and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Aim

Subject and methods

Results

Conclusion

Please log in to get access to this content