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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 5/2020

01-05-2020 | Chronic Inflammatory Bowel Disease | Editorial

Mixed Bag: How C. Difficile Can Cause Pouchitis

Author: Michael J. Stewart

Published in: Digestive Diseases and Sciences | Issue 5/2020

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Excerpt

Clostridium difficile infection (CDI), a major cause of healthcare associated infections, has become a consistent frustration of hospital-based clinicians. Worldwide, the highest rates of hospital-associated CDI occur in North America, where an estimated 7.14 of 1000 hospital admissions are complicated by CDI [1]. Clostridium difficile is a fastidious spore-forming gram-positive anaerobic bacterium that causes infections ranging from mild diarrhea to fulminant colitis. One of the strongest risk factors for CDI is prior antibiotic exposure resulting presumably from the disruption of the intestinal microbiota, although a number of other risk factors have been identified. …
Literature
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Balsells E, Shi T, Leese C, et al. Global burden of Clostridium difficile infections: A systematic review and meta-analysis. J Glob Health. 2019;9:407.
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Nguyen G, Kaplan GG, Harris ML, Brant SR. A national survey of the prevalence and impact of Clostridium difficile infection among hospitalized inflammatory bowel disease patients. Am J Gastroenterol. 2008;103:1443–1450.CrossRef
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Ananthakrishnan AN, McGinley EL, Saeian K, Binion DG. Temporal trends in disease outcomes related to clostridium difficile infection in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2011;17:976–983.CrossRef
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Joshi NM, Marks IH, Crowson R, Ball D, Rampton DS. Incidence and outcome of Clostridium difficile infection in hospitalized patients with inflammatory bowel disease in the UK. J Crohn’s Colitis. 2017;11:70–76.CrossRef
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Seril DN, Shen B. Clostridium difficile infection in the postcolectomy patient. Inflamm Bowel Dis 2014;2014:2450–2469.CrossRef
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Kistangari G, Lopez R, Shen B. Frequency and Risk Factors of Clostridium difficile Infection in Hospitalized Patients with Pouchitis: A Population-based Study. Inflamm Bowel Dis. 2017;23:661–671.CrossRef
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Shen BO, Jiang ZD, Fazio VW, et al. Clostridium difficile Infection in Patients With Ileal Pouch-Anal Anastomosis. Clin Gastroenterol Hepatol. 2008;6:782–788.CrossRef
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Li Y, Qian J, Queener E, Shen B. Risk factors and outcome of PCR-detected clostridium difficile infection in ileal pouch patients. Inflamm Bowel Dis. 2013;19:397–403.CrossRef
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Nguyen GC, Murthy SK, Bressler B, et al. Quality of Care and Outcomes among Hospitalized Inflammatory Bowel Disease Patients: A Multicenter Retrospective Study. Inflamm Bowel Dis. 2017;23:695–701.CrossRef
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Regnault H, Bourrier A, Lalande V, et al. Prevalence and risk factors of Clostridium difficile infection in patients hospitalized for flare of inflammatory bowel disease: A retrospective assessment. Dig Liver Dis. 2014;46:1086–1092.CrossRef
Metadata
Title
Mixed Bag: How C. Difficile Can Cause Pouchitis
Author
Michael J. Stewart
Publication date
01-05-2020
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 5/2020
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-019-05992-x

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