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Open Access 12-02-2024 | Chronic Inflammatory Bowel Disease | RESEARCH

Risk of atrial fibrillation development in adolescent patients with inflammatory bowel disease

Authors: Doaa El Amrousy, Heba El Ashry, Sara Maher, Mohamed Hamza, Samir Hasan

Published in: European Journal of Pediatrics | Issue 4/2024

Abstract

There is increasing evidence linking chronic inflammation to the initiation and continuation of atrial fibrillation (AF). Inflammatory bowel diseases (IBD), namely (Crohn’s disease (CD) and ulcerative colitis (UC), are chronic systemic inflammatory disorders with both intestinal and extra-intestinal manifestations. Atrial electromechanical delay (EMD) has been known as an early marker of AF. The objective of this study was to evaluate the atrial electromechanical properties in children and adolescents with IBD during remission. One hundred IBD patients aged 12–17 years (50 with CD and 50 with UC) in remission state and 100 healthy controls were recruited for the study. Atrial electromechanical properties were measured using transthoracic echocardiography, tissue Doppler imaging, and simultaneous surface ECG recording. Interatrial EMD, left intra-atrial, and right intra-atrial EMD were calculated. IBD patients in remission state have significantly prolonged left and right intra-atrial EMD and interatrial EMD compared to healthy controls (P = 0.03, P = 0.02, and P = 0.01 respectively). No statistical difference was observed between CD and UC in terms of inter- and intra-atrial EMDs.

Conclusion: Atrial EMD is increased in pediatric patients with IBD indicating the increased risk of AF development. Measurement of atrial EMD parameters might be used to predict the risk of the development of AF in pediatric patients with IBD.

What is Known: • There is increasing evidence linking chronic inflammation to the initiation and continuation of atrial fibrillation (AF). • Inflammatory bowel diseases are chronic systemic inflammatory disorders with both intestinal and extra-intestinal manifestations. • Atrial electromechanical delay (EMD) has been reported as an early marker of AF.
What is New: • Atrial EMD is increased in pediatric patients with IBD indicating the increased risk of AF development. • Measurement of atrial EMD parameters might be used to predict the risk of the development of AF in pediatric patients with IBD.

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Title: Risk of atrial fibrillation development in adolescent patients with inflammatory bowel disease
Authors: Doaa El Amrousy
Heba El Ashry
Sara Maher
Mohamed Hamza
Samir Hasan
Publication date: 12-02-2024
Publisher: Springer Berlin Heidelberg
Keywords: Chronic Inflammatory Bowel Disease
Atrial Fibrillation
Ulcerative Colitis
Crohn's Disease
Electrocardiography
Electrocardiography
Published in: European Journal of Pediatrics / Issue 4/2024
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-024-05468-9

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Risk of atrial fibrillation development in adolescent patients with inflammatory bowel disease

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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