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International Ophthalmology
Published in: International Ophthalmology 11/2019

01-11-2019 | Original Paper

Choroidal thickness in macular holes

Authors: Sabahattin Sul, Gökhan Gurelik, Şafak Korkmaz, Cemal Ozsaygili

Published in: International Ophthalmology | Issue 11/2019

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Abstract

Purpose

To determine the association between choroidal thickness (CT) and anatomic success in closed and open macular holes (MHs) following surgery.

Methods

One hundred and thirty-six eyes of 136 patients who underwent surgery due to primary MH were included in this study. Choroidal thickness was measured from various points (subfoveal, temporal, nasal, superior and inferior 1500 µm from the center of the fovea) in both eyes with MH and fellow eyes. We determined associations among the duration of symptoms, MH dimensions and CTs from various points with anatomic success and correlations between CT and MH dimensions and duration of symptoms.

Results

Choroidal thickness was significantly lower in eyes with MH than fellow eyes in both open and closed MHs. Base diameter [p = 0.025, odds ratio (OR) = 0.428], minimum hole diameter (p = 0.030, OR = 0.211) and duration of symptoms [p = 0.034, OR = 0.443] were significantly associated with anatomic success. However, CTs from various points were not associated with anatomic success despite a significant preoperative subfoveal CT difference between open and closed MHs (198 ± 21 µm in open MHs and 230 ± 30 µm in closed MHs; p < 0.001). Preoperative subfoveal CT was moderately correlated with base diameter (r = − 0.505, p < 0.001), minimum hole diameter (r = − 0.518, p < 0.001) and duration of symptoms (r = − 0.510, p < 0.001).

Conclusions

Failed MHs were associated with larger hole dimensions (base diameter and minimum hole diameter) and longer duration of symptoms. Preoperative subfoveal CT was thinner in open MHs, but there was no association with anatomic success. Choroidal thinning may be linked to larger and chronic MHs.
Literature
1.
Gass JD (1995) Reappraisal of biomicroscopic classification of stages of development of a macular hole. Am J Ophthalmol 119(6):752–759CrossRef
2.
Altaweel M, Ip M (2003) Macular hole: improved understanding of pathogenesis, staging, and management based on optical coherence tomography. Semin Ophthalmol 18:58–66CrossRef
3.
Wendel RT, Patel AC, Kelly NE, Salzano TC, Wells JW, Novack GD (1993) Vitreous surgery for macular holes. Ophthalmology 100(11):1671–1676CrossRef
4.
Haritoglou C, Gass CA, Schaumberger M, Gandorfer A, Ulbig MW, Kampik A (2002) Long-term follow-up after macular hole surgery with internal limiting membrane peeling. Am J Ophthalmo 134(5):661–666CrossRef
5.
Gordon LW, Glaser BM, Ie D, Thompson JT, Sjaarda RN (1995) Full-thickness macular hole formation in eyes with a pre-existing complete posterior vitreous detachment. Ophthalmology 102:1702–1705CrossRef
6.
Lee SH, Park KH, Kim JH, Heo JW, Yu HG, Yu YS et al (2010) Secondary macular hole formation after vitrectomy. Retina 30:1072–1077CrossRef
7.
Aras C, Ocakoglu O, Akova N (2004) Foveolar choroidal blood flow in idiopathic macular hole. Int Ophthalmol 25:225–231CrossRef
8.
Zhang P, Zhou M, Wu Y, Lu B, Li T, Zhao J et al (2017) Choroidalthickness inunilateal idiopathic macular hole: a cross-sectional study and meta-analysis. Retina 37(1):60–69CrossRef
9.
Willis AW, Garcia-Cosio JF (1996) Macular hole surgery: comparison of longstanding versus recent macular holes. Ophthalmology 103:1811–1814CrossRef
10.
Ip MS, Baker BJ, Duker JS, Reichel E, Baumal CR, Gangnon R et al (2002) Anatomical outcomes of surgery for idiopathic macular hole as determined by optical coherence tomography. Arch Ophthalmol 120(1):29–35CrossRef
11.
Wakely L, Rahman R, Stephenson JA (2012) Comparison of several methods of macular hole measurement using optical coherence tomography, and their value in predicting anatomical and visual outcomes. Br J Ophthalmol 96(7):1003–1007CrossRef
12.
Ullrich S, Haritoglou C, Gass C, Schaumberger M, Mw Ulbig, Kampik A et al (2002) Macular hole size as a prognostic factor in macular hole surgery. Br J Ophthalmol 86:390–393CrossRef
13.
Kusuhara S, Teraoka Escano MF, Fujii S, Nakanishi Y, Tamura Y, Nagai A et al (2004) Prediction of postoperative visual outcome based on hole configuration by optical coherence tomography in eyes with idiopathic macular holes. Am J Ophthalmol 138:709–716CrossRef
14.
Ruiz-Moreno JM, Staicu C, Pinero DP, Montero J, Lugo F, Amat P (2008) Optical coherence tomography predictive factors for macular hole surgery outcome. Br J Ophthalmol 92:640–644CrossRef
15.
Flügel C, Tamm ER, Mayer B, Lutjen-Drecoll E (1994) Species differences in choroidal vasodilative innervation: evidence for specific intrinsic nitrergic and VIP-positive neurons in the human eye. Investig Ophthalmol Vis Sci 35:592–599
16.
Xu LT, Srivastava SK, Ehlers JP, Kaiser PK (2015) Choroidal thickness in macular holes: a case-control study. Ophthalmic Surg Lasers Imaging Retina 46(1):33–37CrossRef
17.
Reibaldi M, Boscia F, Avitabile T, Uva MG, Russo V, Zagari M et al (2011) Enhanced depth imaging optical coherence tomography of the choroid in idiopathic macular hole: a cross-sectional prospective study. Am J Ophthalmol 151(1):112–117CrossRef
18.
Zeng J, Li J, Liu R, Chen X, Pan J, Tang S et al (2012) Choroidal thickness in both eyes of patients with unilateral idiopathic macular hole. Ophthalmology 119:2328–2333CrossRef
19.
Michalewska Z, Michalewski J, Nawrocka Z, Dulczewska-Cichecka K, Nawrocki J (2015) The outer choroidoscleral boundary in full-thickness macular holes before and after surgery—a swept-source OCT study. Graefes Arch Clin Exp Ophthalmol 253:2087–2093CrossRef
20.
Rawji MH, Flanagan JG (2001) Intraocular and interocular symmetry in normal retinal capillary perfusion. J Glaucoma 10:4–12CrossRef
21.
Teng Y, Yu M, Wang Y, Liu X, You Q, Liu W (2017) OCT angiography quantifying choriocapillary circulation in idiopathic macular hole before and after surgery. Graefes Arch Clin Exp Ophthalmol 255(5):893–902CrossRef
22.
Allen RD, Brown J, Zwick H (2004) Laser-induced macular holes demonstrate impaired choroidal perfusion. Retina 24:92–97CrossRef
Metadata
Title
Choroidal thickness in macular holes
Authors
Sabahattin Sul
Gökhan Gurelik
Şafak Korkmaz
Cemal Ozsaygili
Publication date
01-11-2019
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 11/2019
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-019-01108-6

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