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European Archives of Oto-Rhino-Laryngology

Open Access 22-03-2024 | Cholesteatoma | Otology

Occurrence of mucosa-affecting diseases of the upper airways in middle ear cholesteatoma patients: a nationwide case–control study

Authors: Agnes Modée Borgström, Hanna Mogensen, Cecilia Engmér Berglin, Johan Knutsson, Åsa Bonnard

Published in: European Archives of Oto-Rhino-Laryngology

Abstract

Purpose

Exploring a possible link between upper airway inflammation and the development of cholesteatoma by studying the association between mucosa-affecting diseases of the upper airways and cholesteatoma surgery.

Methods

This is a nationwide case–control study of 10,618 patients who underwent surgery for cholesteatoma in Sweden between 1987 and 2018. The cases were identified in the National Patient Register and 21,235 controls matched by age, sex and place of residency were included from national population registers. Odds ratios (OR) and corresponding 95% confidence intervals were used to assess the association between six types of mucosa-affecting diseases of the upper airways and cholesteatoma surgery.

Results

Chronic rhinitis, chronic sinusitis and nasal polyposis were more common in cholesteatoma patients than in controls (OR 1.5 to 2.5) as were both adenoid and tonsil surgery (OR > 4) where the strongest association was seen for adenoid surgery. No association was seen between allergic rhinitis and cholesteatoma.

Conclusion

This study supports an association between mucosa-affecting diseases of the upper airways and cholesteatoma. Future studies should aim to investigate the mechanisms connecting mucosa-affecting diseases of the upper airways and cholesteatoma formation regarding genetic, anatomical, inflammatory and mucosa properties.

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Title: Occurrence of mucosa-affecting diseases of the upper airways in middle ear cholesteatoma patients: a nationwide case–control study
Authors: Agnes Modée Borgström
Hanna Mogensen
Cecilia Engmér Berglin
Johan Knutsson
Åsa Bonnard
Publication date: 22-03-2024
Publisher: Springer Berlin Heidelberg
Keywords: Cholesteatoma
Tonsillectomy
Allergic Rhinitis
Published in: European Archives of Oto-Rhino-Laryngology
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-024-08567-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Occurrence of mucosa-affecting diseases of the upper airways in middle ear cholesteatoma patients: a nationwide case–control study

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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