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Published in: Calcified Tissue International 6/2023

Open Access 24-10-2023 | Cholesteatoma | Original Research

Cholesteatoma Severely Impacts the Integrity and Bone Material Quality of the Incus

Authors: Maximilian M. Delsmann, Paul Bonik, Ana Ocokoljic, Sophia M. Häussler, Klaus Püschel, Mark Praetorius, Michael Amling, Jonathan Peichl, Tim Rolvien

Published in: Calcified Tissue International | Issue 6/2023

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Abstract

Cholesteatoma can lead to progressive destruction of the auditory ossicles along with conductive hearing loss but precise data on the microstructural, cellular, and compositional aspects of affected ossicles are not available. Here, we obtained incus specimens from patients who had cholesteatoma with conductive hearing loss. Incudes were evaluated by micro-computed tomography, histomorphometry on undecalcified sections, quantitative backscattered electron imaging, and nanoindentation. Results were compared with two control groups taken from patients with chronic otitis media as well as from skeletally intact donors at autopsy. The porosity of incus specimens was higher in cholesteatoma than in chronic otitis media, along with a higher osteoclast surface per bone surface. Histomorphometric assessment revealed higher osteoid levels and osteocyte numbers in cholesteatoma incudes. Incudes affected by cholesteatoma also showed lower matrix mineralization compared with specimens from healthy controls and chronic otitis media. Furthermore, the modulus-to-hardness ratio was higher in cholesteatoma specimens compared with controls. Taken together, we demonstrated increased porosity along with increased osteoclast indices, impaired matrix mineralization, and altered biomechanical properties as distinct features of the incus in cholesteatoma. Based on our findings, a possible impact of impaired bone quality on conductive hearing loss should be further explored.
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Metadata
Title
Cholesteatoma Severely Impacts the Integrity and Bone Material Quality of the Incus
Authors
Maximilian M. Delsmann
Paul Bonik
Ana Ocokoljic
Sophia M. Häussler
Klaus Püschel
Mark Praetorius
Michael Amling
Jonathan Peichl
Tim Rolvien
Publication date
24-10-2023
Publisher
Springer US
Published in
Calcified Tissue International / Issue 6/2023
Print ISSN: 0171-967X
Electronic ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-023-01144-6

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