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Open Access 25-03-2024 | Cholangitis | BRIEF REPORT

COVID-19-associated secondary sclerosing cholangitis with liver transplantation

Authors: Anne Kristin Fischer, Dirk Stippel, Ali Canbay, Dirk Nierhoff, Michael Thomas, Jan Best, Reinhard Büttner, Uta Drebber

Published in: Virchows Archiv

Abstract

We report on two cases of orthotopic liver transplantation (OLTX) due to SARS-Cov2-associated secondary sclerosing cholangitis (SSC) following long-term artificial respiration and extra-corporal membrane oxygenation in intensive care. Under these conditions, SSC is a rapidly progredient biliary disease featuring degenerative cholangiopathy, loss of bile ducts, ductular and parenchymal cholestasis, biliary fibrosis, and finally cirrhosis. Reduced perfusion and oxygenation of the peribiliary plexus, severe concurrent infections, and secondary medico-toxic effects appear to play a crucial role in the pathogenesis of the disease. A direct cytopathic effect of SARS-Cov2 on endothelial cells followed by thrombosis and fibrosing obliteration in all parts of the vascular bed of the liver may enhance the virus-associated liver disease and particularly SSC.

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Title: COVID-19-associated secondary sclerosing cholangitis with liver transplantation
Authors: Anne Kristin Fischer
Dirk Stippel
Ali Canbay
Dirk Nierhoff
Michael Thomas
Jan Best
Reinhard Büttner
Uta Drebber
Publication date: 25-03-2024
Publisher: Springer Berlin Heidelberg
Keywords: Cholangitis
COVID-19
Liver Transplantation
Liver Transplantation
Liver Transplantation
Liver Transplantation
Liver Transplantation
Published in: Virchows Archiv
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-024-03753-4

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Springer Medicine

COVID-19-associated secondary sclerosing cholangitis with liver transplantation

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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