Published in:
10-12-2023 | Cholangitis | ASO Author Reflections
ASO Author Reflections: Impact of Neutrophil Extracellular Traps on Extrahepatic Cholangiocarcinomas
Authors:
Hiroyuki Yamamoto, MD, Yoshitsugu Nakanishi, MD, PhD, Satoshi Hirano, MD, PhD
Published in:
Annals of Surgical Oncology
|
Issue 2/2024
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Excerpt
Malignant tumors and the immune system are closely associated, and tumor-related inflammation is an important host-related factor that may affect the prognosis of patients with tumors.
1 In recent years, neutrophil extracellular traps (NETs), which originate from neutrophils, have received much attention for their role in tumor biology.
2 In patients with extrahepatic cholangiocarcinoma (EHCC), preoperative cholangitis often occurs due to obstruction of the bile ducts, and some studies have reported that patients who develop preoperative cholangitis have a poor prognosis.
3 Although inflammation is known to play an important role in tumor progression,
4 the mechanism by which preoperative cholangitis worsens the prognosis of patients with EHCC remains unclear. …
