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Published in: Child's Nervous System 8-9/2005

01-08-2005 | Special Annual Issue

Childhood craniopharyngioma: Vancouver experience

Authors: Juliette Hukin, Johann Visser, Michael Sargent, Karen Goddard, Chris Fryer, Paul Steinbok

Published in: Child's Nervous System | Issue 8-9/2005

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Abstract

Objective

To present our institution’s experience in the management of childhood craniopharyngioma since 1982.

Methods

We retrospectively reviewed the records of all children diagnosed with craniopharyngioma at our children’s hospital from its opening in 1982 through to 2003. One neuroradiologist systematically reviewed the neuroimaging. Kaplan–Meier curves were used to analyze the progression-free survival and the overall survival from the time of the first definitive intervention.

Conclusions

Most children diagnosed with craniopharyngioma are long-term survivors. Survivors suffer from multiple deficits in the long term. A conservative surgical and radiotherapeutic approach and avoiding interventions that are known to cause severe morbidity may minimize these. The use of intracystic bleomycin is a strategy that allows the delay of more aggressive therapies in select patients.
Literature
1.
go back to reference Baskin DS, Wilson CB (1986) Surgical management of craniopharyngiomas. A review of 74 cases. J Neurosurg 65(1):22–27 Baskin DS, Wilson CB (1986) Surgical management of craniopharyngiomas. A review of 74 cases. J Neurosurg 65(1):22–27
2.
go back to reference Bunin GR, Surawicz TS, Witman PA, Preston-Martin S, Davis F, Bruner JM (1998) The descriptive epidemiology of craniopharyngioma. J Neurosurg 89:547–551PubMed Bunin GR, Surawicz TS, Witman PA, Preston-Martin S, Davis F, Bruner JM (1998) The descriptive epidemiology of craniopharyngioma. J Neurosurg 89:547–551PubMed
3.
go back to reference Danoff BF, Cowchock FS, Kramer S (1983) Childhood craniapharyngioma: survival, local control, endocrine and neurologic function following radiotherapy. Int J Radiat Oncol Biol Phys 9:171–175PubMed Danoff BF, Cowchock FS, Kramer S (1983) Childhood craniapharyngioma: survival, local control, endocrine and neurologic function following radiotherapy. Int J Radiat Oncol Biol Phys 9:171–175PubMed
4.
go back to reference Gonc EN, Yordam N, Ozon A, Alikasifoglu A, Kandemir N (2004) Endocrinological outcome of different treatment options in children with craniopharyngioma: a retrospective analysis of 66 cases. Pediatr Neurosurg 40:112–119CrossRefPubMed Gonc EN, Yordam N, Ozon A, Alikasifoglu A, Kandemir N (2004) Endocrinological outcome of different treatment options in children with craniopharyngioma: a retrospective analysis of 66 cases. Pediatr Neurosurg 40:112–119CrossRefPubMed
5.
go back to reference Hader WJ, Steinbok P, Hukin J, Fryer C (2000) Intratumoral therapy with bleomycin for cystic craniopharyngiomas in children. Pediatr Neurosurg 33:211–218CrossRefPubMed Hader WJ, Steinbok P, Hukin J, Fryer C (2000) Intratumoral therapy with bleomycin for cystic craniopharyngiomas in children. Pediatr Neurosurg 33:211–218CrossRefPubMed
6.
go back to reference Laws ER Jr, Thapar K (1994) The diagnosis and management of craniopharyngioma. Growth Genet Horm 10(3):6–11 Laws ER Jr, Thapar K (1994) The diagnosis and management of craniopharyngioma. Growth Genet Horm 10(3):6–11
7.
go back to reference Merchant TE, Kiehna EN, Sanford RA, Mulhern RK, Thompson SJ, Wilson MW, Lustig RH, Kun LE (2002) Craniopharyngioma: the St. Jude children’s research hospital experience 1984–2001. Int J Radiat Oncol Biol Phys 53(3):533–542CrossRefPubMed Merchant TE, Kiehna EN, Sanford RA, Mulhern RK, Thompson SJ, Wilson MW, Lustig RH, Kun LE (2002) Craniopharyngioma: the St. Jude children’s research hospital experience 1984–2001. Int J Radiat Oncol Biol Phys 53(3):533–542CrossRefPubMed
8.
go back to reference Poretti A, Grotzer MA, Ribi K, Schonle E, Boltshauser E (2004) Outcome of craniopharyngioma in children: long-term complications and quality of life. Dev Med Child Neurol 46:220–229CrossRefPubMed Poretti A, Grotzer MA, Ribi K, Schonle E, Boltshauser E (2004) Outcome of craniopharyngioma in children: long-term complications and quality of life. Dev Med Child Neurol 46:220–229CrossRefPubMed
9.
go back to reference Richmond IL, Wara WM, Wilson CB (1980) Role of radiation therapy in the management of craniopharyngiomas in children. Neurosurgery 6(5):513–517PubMed Richmond IL, Wara WM, Wilson CB (1980) Role of radiation therapy in the management of craniopharyngiomas in children. Neurosurgery 6(5):513–517PubMed
10.
go back to reference Riva D, Pantaleoni C, Devoti M, Saletti V, Nichelli F, Giorgi C (1998) Late neuropsychological and behavioural outcome of children surgically treated for craniopharyngioma. Childs Nerv Syst 14:179–184CrossRefPubMed Riva D, Pantaleoni C, Devoti M, Saletti V, Nichelli F, Giorgi C (1998) Late neuropsychological and behavioural outcome of children surgically treated for craniopharyngioma. Childs Nerv Syst 14:179–184CrossRefPubMed
11.
go back to reference Stripp DCH, Maity A, Janss AJ, Belasco JB, Tochner ZA, Goldwein JW, Moshang T, Rorke LB, Phillips PC, Sutton LN, Shu HG (2004) Surgery with or without radiation therapy in the management of craniopharyngiomas in children and young adults. Int J Radiat Oncol Biol Phys 58(3):714–720 Stripp DCH, Maity A, Janss AJ, Belasco JB, Tochner ZA, Goldwein JW, Moshang T, Rorke LB, Phillips PC, Sutton LN, Shu HG (2004) Surgery with or without radiation therapy in the management of craniopharyngiomas in children and young adults. Int J Radiat Oncol Biol Phys 58(3):714–720
Metadata
Title
Childhood craniopharyngioma: Vancouver experience
Authors
Juliette Hukin
Johann Visser
Michael Sargent
Karen Goddard
Chris Fryer
Paul Steinbok
Publication date
01-08-2005
Publisher
Springer-Verlag
Published in
Child's Nervous System / Issue 8-9/2005
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-005-1220-7

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