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BMC Pediatrics
Published in: BMC Pediatrics 1/2019

Open Access 01-12-2019 | Childhood Asthma | Research article

Effects of particulate matter (PM) on childhood asthma exacerbation and control in Xiamen, China

Authors: Jinzhun Wu, Taoling Zhong, Yu Zhu, Dandan Ge, Xiaoliang Lin, Qiyuan Li

Published in: BMC Pediatrics | Issue 1/2019

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Abstract

Background

The short-term effects of particulate matter (PM) exposure on childhood asthma exacerbation and disease control rate is not thoroughly assessed in Chinese population yet. The previous toxic effects of PM exposure are either based on long-term survey or experimental data from cell lines or mouse models, which also needs to be validated by real-world evidences.

Methods

We evaluated the short-term effects of PM exposure on asthma exacerbation in a Chinese population of 3106 pediatric outpatientsand disease control rate (DCR) in a population of 3344 children using case-crossover design. All the subjects enrolled are non-hospitalized outpatients. All data for this study were collected from the electronic health record (EHR) in the period between January 1, 2016 and June 30, 2018 in Xiamen, China.

Results

We found that exposure to PM2.5 and PM10 within the past two weeks was significantly associated with elevated risk of exacerbation (OR = 1.049, p < 0.001 for PM2.5and OR = 1.027, p < 0.001 for PM10). In addition, exposure to PM10 was associated with decreased DCR (OR = 0.976 for PM10, p < 0.001).

Conclusions

Our results suggest that exposure to both PM10 and PM2.5 has significant short-term effects on childhood asthma exacerbation and DCR, which serves as useful epidemiological parameters for clinical management of asthma risk in the sensitive population.
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Metadata
Title
Effects of particulate matter (PM) on childhood asthma exacerbation and control in Xiamen, China
Authors
Jinzhun Wu
Taoling Zhong
Yu Zhu
Dandan Ge
Xiaoliang Lin
Qiyuan Li
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2019
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-019-1530-7

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