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Child's Nervous System
Published in: Child's Nervous System 10/2007

01-10-2007 | Case Report

Chiari I malformation and idiopathic growth hormone deficiency in siblings: report of three cases

Authors: R. Lee Murphy, R. Shane Tubbs, Paul A. Grabb, W. Jerry Oakes

Published in: Child's Nervous System | Issue 10/2007

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Abstract

Introduction

The authors report a case of three brothers.

Case descriptions

Two of these siblings presented with congenital growth hormone deficiency (GHD) and Chiari I malformation (CIM). The third younger brother has been found not to have GHD or the CIM.

Discussion

Sparse cases of these two clinical occurrences have been reported. Further, the posterior cranial fossa (PF) has been determined to be altered in patients with CIM and GHD.

Conclusion

Our current case reports strengthen the association between these two pathological entities and, to our knowledge, is the first description of both defects in siblings.
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Metadata
Title
Chiari I malformation and idiopathic growth hormone deficiency in siblings: report of three cases
Authors
R. Lee Murphy
R. Shane Tubbs
Paul A. Grabb
W. Jerry Oakes
Publication date
01-10-2007
Publisher
Springer-Verlag
Published in
Child's Nervous System / Issue 10/2007
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-007-0374-x

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