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Child's Nervous System

Published in:

01-10-2007 | Original Paper

Prevalence of neural tube defects in economically and socially deprived area of China

Authors: Jie Liu, Guo Z. Yang, Jin L. Zhou, Shi P. Cao, David H. W. Chau, Hsiang-fu Kung, Marie C. Lin

Published in: Child's Nervous System | Issue 10/2007

Abstract

Objective

This paper aims to understand the situation and epidemiology trend of neural tube defects in Guizhou province, China from 1996 to 2004.

Study design

Pregnant women from 17 hospitals in Guizhou province were chosen for investigation of perinatal infants from January 1996 to December 2004.

Results

Of 1,208 birth defect cases studied in this 9-year period, a total of 122 cases were identified as neural tube defects (NTD), making up a 10.10% of the total birth defects. The average prevalence rate of NTD was 12.21 per 10,000 births; however, there is no significant difference between the genders. In this study, the age of mothers during pregnancy was shown to be one of the major factors affecting the prevalence rate of NTD and the differences between infants with or without NTD and the usage of folic acid as a supplement during pregnancy were found to be statistical significant.

Conclusion

NTD was found to be the most common and serious form of human birth defect in Guizhou province. For prevention, folic acid supplement is thought to be efficacious in inhibiting NTD, and thus, it is essential for people in socially deprived areas to effectively reduce the prevalence of NTD in China.

Botto LD, Lisi A, Robert-Gnansia E, Erickson JD, Vollset SE, Mastroiacovo P, Botting B, Cocchi G, de Vigan C, de Walle H, Feijoo M, Irgens LM, McDonnell B, Merlob P, Ritvanen A, Scarano G, Siffel C, Metneki J, Stoll C, Smithells R, Goujard J (2005) International retrospective cohort study of neural tube defects in relation to folic acid recommendations: are the recommendations working? BMJ 330:571PubMedCrossRef

Cabrera RM, Hill DS, Etheredge AJ, Finnell RH (2004) Investigations into the etiology of neural tube defects. Birth Defects Res C Embryo Today 72:330–344PubMedCrossRef

Cheng ZP (2003) Current state of development of neural tube defects. Pract Prev Med 10:263–265

Chi H, Sarkisian MR, Rakic P, Flavell RA (2005) Loss of mutagen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. Proc Natl Acad Sci U S A 102:3846–3851PubMedCrossRef

Dai L, Zhu J, Zhou GX, Wang YP, Wu YQ, Miao L, Liang J (2002) Dynamic monitoring of neural tube defects in China during 1996 to 2000. Chin J Prev Med 36:402–406

Dai L, Zhu J, Zhou GX, Wu YQ, Wang YP, Miao L, Liang J (2003) Clinical features of 3798 prenatal suffering from syndromes neural tube defects. Chin J Obstet Gynecol 38:17–20

Ding XP (2005) Birth-defect intervention project—an important way to realize birth health. In: Ding XP, Li CG (eds) 1st edn. Renlei Yichuan Yu Yousheng. People’s Military Medical, Beijing, pp92–98

Gurniak CB, Perlas E, Witke W (2005) The actin depolymerizing factor n-coiling is essential for neural tube morphogenesis and neural crest cell migration. Dev Biol 278:231–241PubMedCrossRef

La G, Su HQ, Li YZ, Wang YY (2003) Statistical analysis on the prevalence of neural tube defects in the past ten years in Beijing. Chin J Birth Health Hered 11:122–124

10.

Lv Y, Chen JQ, Lin ZR, Hua H, Gong H (2002) An investigation on the application of folic acid in the prevention of prenatal occurrence of neural tube defects. Nanjing Med Univ J 22:259–260

11.

Rothenberg SP, da Costa MP, Sequeira JM, Cracco J, Roberts JL, Weedon J, Quadros EV (2004) Autoantibodies against foliate receptors in women with a pregnancy complicated by a neural-tube defect. N Engl J Med 350:134–142PubMedCrossRef

12.

Saitsu H, Yamada S, Uwabe C, Ishibashi M, Shiota K (2004) Development of the posterior neural tube in human embryos. Anat Embryol (Berl) 209:107–117

13.

Shaw GM, Carmichael SL, Yang W, Schaffer DM (2005) Preconception dietary intake of myo-inositol and neural tube defects in offspring. Birth Defects Res A Clin Mol Teratol 73:184–187PubMedCrossRef

14.

Sheu WH, Chin HM, Lee WJ, Wan CJ, Su HY, Lang HF (2005) Prospective evaluation of folic acid supplementation on plasma homocysteine concentrations during weight reduction: a randomized, double-blinded, placebo-controlled study in obese women. Life Sci 76:2137–2145PubMedCrossRef

15.

Tang ZH (2000) Suspected dangerous factors causing neural tube defects. Chin J Fam Plann 3:140–142

16.

Ye KW, Li S, Zheng JC, Hung SX, Chen X, Wang TM, Ren AG, Wang LN, Li Z (2002) Prevalence of neural tube defects at birth in 30 counties and cities of China. 1993–2000. J Peking Univ (Health Sci) 34:204–209

17.

Zhang L, Li ZW, Ren AG, Li Z (2003) Factors influencing folic acid supplementary behavior of women in reproductive age. Foreign Med Sci (Sect Matern Child Health) 14:328–330

18.

Zheng MM, Hu YL (2003) Neural tube defects and their etiology. Foreign Med Sci (Sect Matern Child Health) 14:282–284

Title: Prevalence of neural tube defects in economically and socially deprived area of China
Authors: Jie Liu
Guo Z. Yang
Jin L. Zhou
Shi P. Cao
David H. W. Chau
Hsiang-fu Kung
Marie C. Lin
Publication date: 01-10-2007
Publisher: Springer-Verlag
Published in: Child's Nervous System / Issue 10/2007
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-007-0344-3

At a glance: The STEP trials

Springer Medicine

Prevalence of neural tube defects in economically and socially deprived area of China

Abstract

Objective

Study design

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Study design

Results

Conclusion

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