Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Inflammation
Published in: Inflammation 1/2012

01-02-2012

Chemical Mediators of Inflammation and Resolution in Post-Operative Abdominal Aortic Aneurysm Patients

Authors: Padmini S. Pillai, Stanley Leeson, Timothy F. Porter, Christopher D. Owens, Ji Min Kim, Michael S. Conte, Charles N. Serhan, Simon Gelman

Published in: Inflammation | Issue 1/2012

Login to get access

Abstract

Temporal–metabolomic studies of local mediators during inflammation and its resolution uncovered novel pathways and mediators, e.g., lipoxins, resolvins, and protectins that stimulate key resolution responses. Since these studies were carried out with isolated human cells and in animal models, it is important to determine in humans whether temporal profiles between pro-inflammatory mediators and pro-resolving mediators are demonstrable in vivo. To this end, we examined patients undergoing abdominal aortic aneurysm (AAA) surgery. Profiles of mediators including eicosanoids were assessed in addition to pro-resolving mediators. The results demonstrate temporal relationships for local-acting peptides (e.g., VEGF, IL-10, TGFβ) and lipid mediators (leukotrienes and resolvins). In addition, profiles obtained for AAA patients divided into two groups based on their temporal profile: one group consistent with a pro-inflammatory and another with a resolving profile. Together, these translational metabolomic profiles demonstrate for the first time the temporal relationships between local mediators in humans relevant in inflammation resolution.
Literature
1.
Kumar, V., A.K. Abbas, N. Fausto, S.L. Robbins, and R.S. Cotran. 2005. Robbins and Cotran pathologic basis of disease, 7th ed. Philadelphia: Elsevier Saunders.
2.
Serhan, C.N., S.D. Brain, C.D. Buckley, D.W. Gilroy, C. Haslett, L.A. O’Neill, M. Perretti, A.G. Rossi, and J.L. Wallace. 2007. Resolution of inflammation: State of the art, definitions and terms. The FASEB Journal 21: 325–332.PubMedCrossRef
3.
Perry, V.H., C. Cunningham, and C. Holmes. 2007. Systemic infections and inflammation affect chronic neurodegeneration. Nature Reviews. Immunology 7: 161–167.PubMedCrossRef
4.
Hansson, G.K., and P. Libby. 2006. The immune response in atherosclerosis: A double-edged sword. Nature Reviews. Immunology 6: 508–519.PubMedCrossRef
5.
Laffey, J.G., J.F. Boylan, and D.C. Cheng. 2002. The systemic inflammatory response to cardiac surgery: Implications for the anesthesiologist. Anesthesiology 97: 215–252.PubMedCrossRef
6.
Gelman, S. 1995. The pathophysiology of aortic cross-clamping and unclamping. Anesthesiology 82: 1026–1060.PubMedCrossRef
7.
Serhan, C.N. 2007. Resolution phase of inflammation: Novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annual Review of Immunology 25: 101–137.PubMedCrossRef
8.
Samuelsson, B., S.E. Dahlen, J.A. Lindgren, C.A. Rouzer, and C.N. Serhan. 1987. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 237: 1171–1176.PubMedCrossRef
9.
Yedgar, S., M. Krimsky, Y. Cohen, and R.J. Flower. 2007. Treatment of inflammatory diseases by selective eicosanoid inhibition: A double-edged sword? Trends in Pharmacological Sciences 28: 459–464.PubMedCrossRef
10.
Levy, B.D., C.B. Clish, B. Schmidt, K. Gronert, and C.N. Serhan. 2001. Lipid mediator class switching during acute inflammation: Signals in resolution. Nature Immunology 2: 612–619.PubMedCrossRef
11.
Serhan, C.N., S. Hong, K. Gronert, S.P. Colgan, P.R. Devchand, G. Mirick, and R.L. Moussignac. 2002. Resolvins: A family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. The Journal of Experimental Medicine 196: 1025–1037.PubMedCrossRef
12.
Serhan, C.N., C.B. Clish, J. Brannon, S.P. Colgan, N. Chiang, and K. Gronert. 2000. Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. The Journal of Experimental Medicine 192: 1197–1204.PubMedCrossRef
13.
Serhan, C.N., R. Yang, K. Martinod, K. Kasuga, P.S. Pillai, T.F. Porter, S.F. Oh, and M. Spite. 2009. Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions. The Journal of Experimental Medicine 206: 15–23.PubMedCrossRef
14.
Serhan, C.N., N. Chiang, and T.E. Van Dyke. 2008. Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators. Nature Reviews. Immunology 8: 349–361.PubMedCrossRef
15.
Schwab, J.M., N. Chiang, M. Arita, and C.N. Serhan. 2007. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature 447: 869–874.PubMedCrossRef
16.
Claria, J., and C.N. Serhan. 1995. Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proceedings of the National Academy of Sciences of the United States of America 92: 9475–9479.PubMedCrossRef
17.
Yang, R., Chiang, N., Oh, S. F., and Serhan, C. N. 2011. Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes. Curr. Protoc. Immunol. (in press).
18.
Samuelsson, B. 1982. From studies of biochemical mechanisms to novel biological mediators: prostaglandin endoperoxides, thromboxanes and leukotrienes. In Les Prix Nobel: Nobel Prizes, Presentations, Biographies and Lectures pp. 153–74, Almqvist & Wiksell, Stockholm
19.
20.
Clouse, W.D., J.W. Hallett Jr., H.V. Schaff, M.M. Gayari, D.M. Ilstrup, and L.J. Melton 3rd. 1998. Improved prognosis of thoracic aortic aneurysms: A population-based study. JAMA 280: 1926–1929.PubMedCrossRef
21.
Lederle, F.A., S.E. Wilson, G.R. Johnson, D.B. Reinke, F.N. Littooy, C.W. Acher, D.J. Ballard, L.M. Messina, I.L. Gordon, E.P. Chute, W.C. Krupski, S.J. Busuttil, G.W. Barone, S. Sparks, L.M. Graham, J.H. Rapp, M.S. Makaroun, G.L. Moneta, R.A. Cambria, R.G. Makhoul, D. Eton, H.J. Ansel, J.A. Freischlag, and D. Bandyk. 2002. Immediate repair compared with surveillance of small abdominal aortic aneurysms. The New England Journal of Medicine 346: 1437–1444.PubMedCrossRef
22.
Pronovost, P.J., M.W. Jenckes, T. Dorman, E. Garrett, M.J. Breslow, B.A. Rosenfeld, P.A. Lipsett, and E. Bass. 1999. Organizational characteristics of intensive care units related to outcomes of abdominal aortic surgery. JAMA 281: 1310–1317.PubMedCrossRef
23.
24.
Lamblin, N., P. Ratajczak, D. Hot, E. Dubois, M. Chwastyniak, O. Beseme, H. Drobecq, Y. Lemoine, M. Koussa, P. Amouyel, and F. Pinet. 2010. Profile of macrophages in human abdominal aortic aneurysms: a transcriptomic, proteomic, and antibody protein array study. J Proteome Res 9(7): 3720–3729.PubMedCrossRef
25.
Abdul-Hussien, H., R. Hanemaaijer, R. Kleemann, B.F. Verhaaren, J.H. van Bockel, and J.H. Lindeman. 2010. The pathophysiology of abdominal aortic aneurysm growth: Corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal artery aneurysms. Journal of Vascular Surgery 51: 1479–1487.PubMedCrossRef
26.
Brand, J.M., H. Kirchner, C. Poppe, and P. Schmucker. 1997. The effects of general anesthesia on human peripheral immune cell distribution and cytokine production. Clinical Immunology and Immunopathology 83: 190–194.PubMedCrossRef
27.
Barry, M.C., C. Kelly, P. Burke, S. Sheehan, H.P. Redmond, and D. Bouchier-Hayes. 1997. Immunological and physiological responses to aortic surgery: Effect of reperfusion on neutrophil and monocyte activation and pulmonary function. The British Journal of Surgery 84: 513–519.PubMedCrossRef
28.
Mayers, I., and D. Johnson. 1998. The nonspecific inflammatory response to injury. Canadian Journal of Anaesthesia 45: 871–879.PubMedCrossRef
29.
Franke, A., W. Lante, V. Fackeldey, H.P. Becker, C. Thode, W.D. Kuhlmann, and A. Markewitz. 2002. Proinflammatory and antiinflammatory cytokines after cardiac operation: Different cellular sources at different times. The Annals of Thoracic Surgery 74: 363–370. discussion 70-1.PubMedCrossRef
30.
Norwood, M.G., T. Horsburgh, M.J. Bown, and R.D. Sayers. 2005. Neutrophil activation occurs in the lower-limbs of patients undergoing elective repair of abdominal aortic aneurysm. European Journal of Vascular and Endovascular Surgery 29: 390–394.PubMed
31.
Wu, S.-H., P.-Y. Liao, P.-L. Yin, Y.-M. Zhang, and L. Dong. 2009. Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis. The American Journal of Pathology 174: 115–122.PubMedCrossRef
32.
Wu, S.-H., P.-Y. Liao, P.-L. Yin, Y.-M. Zhang, and L. Dong. 2009. Inverse temporal changes of lipoxin A4 and leukotrienes in children with Henoch-Schönlein purpura. Prostaglandins Leukotrienes and Essential Fatty Acids 80: 177–183.CrossRef
33.
Morris, T., M. Stables, P. Colville-Nash, J. Newson, G. Bellingan, P.M. de Souza, and D.W. Gilroy. 2010. Dichotomy in duration and severity of acute inflammatory responses in humans arising from differentially expressed proresolution pathways. Proceedings of the National Academy of Sciences of the United States of America 107: 8842–8847.PubMedCrossRef
34.
Morris, T., M. Stables, A. Hobbs, P. de Souza, P. Colville-Nash, T. Warner, J. Newson, G. Bellingan, and D.W. Gilroy. 2009. Effects of low-dose aspirin on acute inflammatory responses in humans. Journal of Immunology 183: 2089–2096.CrossRef
35.
Terrando, N., C. Monaco, D. Ma, B.M. Foxwell, M. Feldmann, and M. Maze. 2010. Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proceedings of the National Academy of Sciences of the United States of America 107: 20518–22.PubMedCrossRef
36.
Ho, K.J., M. Spite, C.D. Owens, H. Lancero, A.H. Kroemer, R. Pande, M.A. Creager, C.N. Serhan, and M.S. Conte. 2010. Aspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis. The American Journal of Pathology 177: 2116–2123.PubMedCrossRef
37.
Zhang, F., H. Yang, Z. Pan, Z. Wang, J.M. Wolosin, P. Gjorstrup, and P.S. Reinach. 2010. Dependence of resolvin-induced increases in corneal epithelial cell migration on EGF receptor transactivation. Investigative Ophthalmology and Visual Science 51: 5601–5609.PubMedCrossRef
38.
Baker, N., S.J. O’Meara, M. Scannell, P. Maderna, and C. Godson. 2009. Lipoxin A4: Anti-inflammatory and anti-angiogenic impact on endothelial cells. Journal of Immunology 182: 3819–3826.CrossRef
39.
Maldonado-Pèriz, D., E. Golightly, F.C. Denison, H.N. Jabbour, and J.E. Norman. 2010. A role for lipoxin A4 as anti-inflammatory and proresolution mediator in human parturition. FASEB J. doi:10.​1096/​fj.​10-170340.
40.
Birnbaum, Y., Y. Ye, Y. Lin, S.Y. Freeberg, M.-H. Huang, J.R. Perez-Polo, and B.F. Uretsky. 2007. Aspirin augments 15-epi-lipoxin A4 production by lipopolysaccharide, but blocks the pioglitazone and atorvastatin induction of 15-epi-lipoxin A4 in the rat heart. Prostaglandins & Other Lipid Mediators 83: 89–98.CrossRef
41.
Planagumà, A., M.A. Pfeffer, G. Rubin, R. Croze, M. Uddin, C.N. Serhan, and B.D. Levy. 2010. Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4. Mucosal Immunol 3: 270–279.PubMedCrossRef
42.
Di Gennaro, A., D. Wågsäter, M.I. Mäyränpää, A. Gabrielsen, J. Swedenborg, A. Hamsten, B. Samuelsson, P. Eriksson, and J.Z. Haeggström. 2010. Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm. Proceedings of the National Academy of Sciences of the United States of America 107: 21093–21097.PubMedCrossRef
43.
Galle, C., V. De Maertelaer, S. Motte, L. Zhou, P. Stordeur, J.P. Delville, R. Li, J. Ferreira, M. Goldman, P. Capel, J.C. Wautrecht, O. Pradier, and J.P. Dereume. 2000. Early inflammatory response after elective abdominal aortic aneurysm repair: A comparison between endovascular procedure and conventional surgery. Journal of Vascular Surgery 32: 234–246.PubMedCrossRef
44.
Chiang, N., S. Hurwitz, P.M. Ridker, and C.N. Serhan. 2006. Aspirin has a gender-dependent impact on antiinflammatory 15-epi-lipoxin A4 formation: A randomized human trial. Arteriosclerosis, Thrombosis, and Vascular Biology 26: e14–e17.PubMedCrossRef
45.
Chiang, N., E.A. Bermudez, P.M. Ridker, S. Hurwitz, and C.N. Serhan. 2004. Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial. Proceedings of the National Academy of Sciences of the United States of America 101: 15178–15183.PubMedCrossRef
46.
Dona, M., G. Fredman, J.M. Schwab, N. Chiang, M. Arita, A. Goodarzi, G. Cheng, U.H. von Andrian, and C.N. Serhan. 2008. Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets. Blood 112: 848–855.PubMedCrossRef
47.
Vane, J. R. 1982. Adventures and excursions in bioassay: the stepping stones to prostacyclin. In Les Prix Nobel: Nobel Prizes, Presentations, Biographies and Lectures pp. 181–206, Almqvist & Wiksell, Stockholm
48.
Massagué, J. 1990. The transforming growth factor-beta family. Annual Review of Cell Biology 6: 597–641.PubMedCrossRef
49.
Ferrara, N. 2004. Vascular endothelial growth factor: Basic science and clinical progress. Endocrine Reviews 25: 581–611.PubMedCrossRef
50.
Serbina, N., T. Jia, T. Hohl, and E. Pamer. 2008. Monocyte-mediated defense against microbial pathogens. Annual Review of Immunology 26: 421–452.PubMedCrossRef
51.
Andre, P. 2004. P-selectin in haemostasis. British Journal Haematology 126: 298–306.CrossRef
52.
DiStasi, M.R., and K. Ley. 2009. Opening the flood-gates: How neutrophil-endothelial interactions regulate permeability. Trends in Immunology 30: 547–556.PubMedCrossRef
Metadata
Title
Chemical Mediators of Inflammation and Resolution in Post-Operative Abdominal Aortic Aneurysm Patients
Authors
Padmini S. Pillai
Stanley Leeson
Timothy F. Porter
Christopher D. Owens
Ji Min Kim
Michael S. Conte
Charles N. Serhan
Simon Gelman
Publication date
01-02-2012
Publisher
Springer US
Published in
Inflammation / Issue 1/2012
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-011-9294-8

Other articles of this Issue 1/2012

Inflammation 1/2012 Go to the issue

OriginalPaper

Effects of TGF-β and b-FGF on the Potential of Peripheral Blood-Borne Stem Cells and Bone Marrow-Derived Stem Cells in Wound Healing in a Murine Model

OriginalPaper

Redistribution of Tight Junction Proteins During EPEC Infection In Vivo

OriginalPaper

Attenuation of Hyperoxia-induced Lung Injury in Rats by Adrenomedullin

OriginalPaper

Inhibitory Effects of Prior Low-dose X-irradiation on Cold-induced Brain Injury in Mouse

OriginalPaper

Cholesterol 27-Hydroxylase but Not Apolipoprotein apoE Contributes to A2A Adenosine Receptor Stimulated Reverse Cholesterol Transport

OriginalPaper

Soluble Urokinase Plasminogen Activator Receptor (suPAR) is Associated with Metabolic Changes in HIV-1-Infected Africans: A Prospective Study
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits