Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Archives of Virology
Published in: Archives of Virology 2/2017

Open Access 01-02-2017 | Original Article

Characterization of a recombinant Newcastle disease virus expressing the glycoprotein of bovine ephemeral fever virus

Authors: Minmin Zhang, Jinying Ge, Zhiyuan Wen, Weiye Chen, Xijun Wang, Renqiang Liu, Zhigao Bu

Published in: Archives of Virology | Issue 2/2017

Login to get access

Abstract

Bovine ephemeral fever (BEF) is caused by the arthropod-borne bovine ephemeral fever virus (BEFV), which is a member of the family Rhabdoviridae and the genus Ephemerovirus. BEFV causes an acute febrile infection in cattle and water buffalo. In this study, a recombinant Newcastle disease virus (NDV) expressing the glycoprotein (G) of BEFV (rL-BEFV-G) was constructed, and its biological characteristics in vitro and in vivo, pathogenicity, and immune response in mice and cattle were evaluated. BEFV G enabled NDV to spread from cell to cell. rL-BEFV-G remained nonvirulent in poultry and mice compared with vector LaSota virus. rL-BEFV-G triggered a high titer of neutralizing antibodies against BEFV in mice and cattle. These results suggest that rL-BEFV-G might be a suitable candidate vaccine against BEF.
Literature
1.
Alexander D (1997) Newcastle disease and other avian paramyxovirus infections. In: Diseases of poultry, vol 50014. Iowa State University Press, Ames, pp 541–569
2.
Bevan L (1912) Ephemeral fever or three day sickness of cattle. Vet J 68:458–461
3.
Buijs PR, Verhagen JH, van Eijck CH, van den Hoogen BG (2015) Oncolytic viruses: From bench to bedside with a focus on safety. Hum Vaccines immunother 11:1573–1584CrossRef
4.
5.
Bukreyev A, Collins PL (2008) Newcastle disease virus as a vaccine vector for humans. Curr Opinion Mol Ther 10:46–55
6.
Coetzer J, Thomson G, Tustin R (1994) Infectious diseases of livestock with special reference to Southern Africa, vol 1. Oxford University Press, Southern Africa
7.
Coll JM (1997) Synthetic peptides from the heptad repeats of the glycoproteins of rabies, vesicular stomatitis and fish rhabdoviruses bind phosphatidylserine. Arch Virol 142:2089–2097CrossRefPubMed
8.
DiNapoli JM, Nayak B, Yang L, Finneyfrock BW, Cook A, Andersen H, Torres-Velez F, Murphy BR, Samal SK, Collins PL, Bukreyev A (2010) Newcastle disease virus-vectored vaccines expressing the hemagglutinin or neuraminidase protein of H5N1 highly pathogenic avian influenza virus protect against virus challenge in monkeys. J Virol 84:1489–1503CrossRefPubMed
9.
DiNapoli JM, Yang L, Samal SK, Murphy BR, Collins PL, Bukreyev A (2010) Respiratory tract immunization of non-human primates with a Newcastle disease virus-vectored vaccine candidate against Ebola virus elicits a neutralizing antibody response. Vaccine 29:17–25CrossRefPubMedPubMedCentral
10.
Gaudin Y, Tuffereau C, Durrer P, Flamand A, Ruigrok RW (1995) Biological function of the low-pH, fusion-inactive conformation of rabies virus glycoprotein (G): G is transported in a fusion-inactive state-like conformation. J Virol 69:5528–5534PubMedPubMedCentral
11.
Gaudin Y, Raux H, Flamand A, Ruigrok RW (1996) Identification of amino acids controlling the low-pH-induced conformational change of rabies virus glycoprotein. J Virol 70:7371–7378PubMedPubMedCentral
12.
Ge J, Deng G, Wen Z, Tian G, Wang Y, Shi J, Wang X, Li Y, Hu S, Jiang Y, Yang C, Yu K, Bu Z, Chen H (2007) Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses. J Virol 81:150–158CrossRefPubMed
13.
Ge J, Wang X, Tao L, Wen Z, Feng N, Yang S, Xia X, Yang C, Chen H, Bu Z (2011) Newcastle disease virus-vectored rabies vaccine is safe, highly immunogenic, and provides long-lasting protection in dogs and cats. J Virol 85:8241–8252CrossRefPubMedPubMedCentral
14.
Ge J, Wang X, Tian M, Wen Z, Feng Q, Qi X, Gao H, Wang X, Bu Z (2014) Novel in-ovo chimeric recombinant Newcastle disease vaccine protects against both Newcastle disease and infectious bursal disease. Vaccine 32:1514–1521CrossRefPubMed
15.
Ge J, Wang X, Tian M, Gao Y, Wen Z, Yu G, Zhou W, Zu S, Bu Z (2015) Recombinant Newcastle disease viral vector expressing hemagglutinin or fusion of canine distemper virus is safe and immunogenic in minks. Vaccine 33:2457–2462CrossRefPubMed
16.
Goff PH, Krammer F, Hai R, Seibert CW, Margine I, Garcia-Sastre A, Palese P (2013) Induction of cross-reactive antibodies to novel H7N9 influenza virus by recombinant Newcastle disease virus expressing a North American lineage H7 subtype hemagglutinin. J Virol 87:8235–8240CrossRefPubMedPubMedCentral
17.
Hertig C, Pye AD, Hyatt AD, Davis SS, McWilliam SM, Heine HG, Walker PJ, Boyle DB (1996) Vaccinia virus-expressed bovine ephemeral fever virus G but not G(NS) glycoprotein induces neutralizing antibodies and protects against experimental infection. J Gen Virol 77(Pt 4):631–640CrossRefPubMed
18.
Huang Z, Elankumaran S, Yunus AS, Samal SK (2004) A recombinant Newcastle disease virus (NDV) expressing VP2 protein of infectious bursal disease virus (IBDV) protects against NDV and IBDV. J Virol 78:10054–10063CrossRefPubMedPubMedCentral
19.
Inaba Y, Kurogi H, Takahashi A, Sato K, Omori T (1974) Vaccination of cattle against bovine ephemeral fever with live attenuated virus followed by killed virus. Arch Gesamte Virusforsch 44:121–132CrossRefPubMed
20.
Johal J, Gresty K, Kongsuwan K, Walker PJ (2008) Antigenic characterization of bovine ephemeral fever rhabdovirus G and GNS glycoproteins expressed from recombinant baculoviruses. Arch Virol 153:1657–1665CrossRefPubMed
21.
Khattar SK, Collins PL, Samal SK (2010) Immunization of cattle with recombinant Newcastle disease virus expressing bovine herpesvirus-1 (BHV-1) glycoprotein D induces mucosal and serum antibody responses and provides partial protection against BHV-1. Vaccine 28:3159–3170CrossRefPubMedPubMedCentral
22.
Kong D, Wen Z, Su H, Ge J, Chen W, Wang X, Wu C, Yang C, Chen H, Bu Z (2012) Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs. Virology 432:327–335CrossRefPubMed
23.
Kongsuwan K, Cybinski DH, Cooper J, Walker PJ (1998) Location of neutralizing epitopes on the G protein of bovine ephemeral fever rhabdovirus. J Gen Virol 79(Pt 11):2573–2581CrossRefPubMed
24.
Kortekaas J, de Boer SM, Kant J, Vloet RP, Antonis AF, Moormann RJ (2010) Rift Valley fever virus immunity provided by a paramyxovirus vaccine vector. Vaccine 28:4394–4401CrossRefPubMed
25.
Mackett M, Yilma T, Rose JK, Moss B (1985) Vaccinia virus recombinants: expression of VSV genes and protective immunization of mice and cattle. Science (New York, NY) 227:433–435CrossRef
26.
Matos PM, Marin M, Ahn B, Lam W, Santos NC, Melikyan GB (2013) Anionic lipids are required for vesicular stomatitis virus G protein-mediated single particle fusion with supported lipid bilayers. J Biol Chem 288:12416–12425CrossRefPubMedPubMedCentral
27.
McMillan TN, Johnson DC (2001) Cytoplasmic domain of herpes simplex virus gE causes accumulation in the trans-Golgi network, a site of virus envelopment and sorting of virions to cell junctions. J Virol 75:1928–1940CrossRefPubMedPubMedCentral
28.
29.
Murphy FA, Taylor WP, Mims CA, Whitfield SG (1972) Bovine ephemeral fever virus in cell culture and mice. Arch Gesamte Virusforsch 38:234–249CrossRefPubMed
30.
Nakaya T, Cros J, Park MS, Nakaya Y, Zheng H, Sagrera A, Villar E, Garcia-Sastre A, Palese P (2001) Recombinant Newcastle disease virus as a vaccine vector. J Virol 75:11868–11873CrossRefPubMedPubMedCentral
31.
Purchase HG, Pathologists AAoA (1989) A laboratory manual for the isolation and identification of avian pathogens. Kendall, London
32.
Rauw F, Gardin Y, Palya V, Van Borm S, Gonze M, Lemaire S, van den Berg T, Lambrecht B (2009) Humoral, cell-mediated and mucosal immunity induced by oculo-nasal vaccination of one-day-old SPF and conventional layer chicks with two different live Newcastle disease vaccines. Vaccine 27:3631–3642CrossRefPubMed
33.
Regan AD, Whittaker GR (2013) Entry of rhabdoviruses into animal cells. Adv Exp Med Biol 790:167–177CrossRefPubMed
34.
Roche S, Albertini AA, Lepault J, Bressanelli S, Gaudin Y (2008) Structures of vesicular stomatitis virus glycoprotein: membrane fusion revisited. Cell Mol Life Sci CMLS 65:1716–1728CrossRefPubMed
35.
Sattentau QJ (2011) The direct passage of animal viruses between cells. Curr Opinion Virol 1:396–402CrossRef
36.
Uren M, Walker P, Zakrzewski H, St George T, Byrne K (1994) Effective vaccination of cattle using the virion G protein of bovine ephemeral fever virus as an antigen. Vaccine 12:845–852CrossRefPubMed
37.
Veits J, Wiesner D, Fuchs W, Hoffmann B, Granzow H, Starick E, Mundt E, Schirrmeier H, Mebatsion T, Mettenleiter TC, Romer-Oberdorfer A (2006) Newcastle disease virus expressing H5 hemagglutinin gene protects chickens against Newcastle disease and avian influenza. Proc Natl Acad Sci USA 103:8197–8202CrossRefPubMedPubMedCentral
38.
Vigil A, Park MS, Martinez O, Chua MA, Xiao S, Cros JF, Martinez-Sobrido L, Woo SL, Garcia-Sastre A (2007) Use of reverse genetics to enhance the oncolytic properties of Newcastle disease virus. Cancer Res 67:8285–8292CrossRefPubMed
39.
Walker PJ, Byrne KA, Cybinski DH, Doolan DL, Wang Y (1991) Proteins of bovine ephemeral fever virus. J Gen Virol 72:67–74CrossRefPubMed
40.
Walker PJ, Byrne KA, Riding GA, Cowley JA, Wang Y, McWilliam S (1992) The genome of bovine ephemeral fever rhabdovirus contains two related glycoprotein genes. Virology 191:49–61CrossRefPubMed
41.
Wallace DB, Viljoen GJ (2005) Immune responses to recombinants of the South African vaccine strain of lumpy skin disease virus generated by using thymidine kinase gene insertion. Vaccine 23:3061–3067CrossRefPubMed
42.
Wen Z, Zhao B, Song K, Hu X, Chen W, Kong D, Ge J, Bu Z (2013) Recombinant lentogenic Newcastle disease virus expressing Ebola virus GP infects cells independently of exogenous trypsin and uses macropinocytosis as the major pathway for cell entry. Virol J 10:331CrossRefPubMedPubMedCentral
43.
Wichgers Schreur PJ (2016) Construction and application of Newcastle disease virus-based vector vaccines. Methods Mol Biol 1349:225–237CrossRefPubMed
44.
Zheng FY, Lin GZ, Qiu CQ (2007) Expression, purification and antigenic characterization of the Epitope-G1 gene of bovine ephemeral fever virus in Escherichia coli. Wei Sheng Wu Xue Bao (Acta Microbiol Sin) 47:498–502
45.
Zhong P, Agosto LM, Munro JB, Mothes W (2013) Cell-to-cell transmission of viruses. Curr Opinion Virol 3:44–50CrossRef
Metadata
Title
Characterization of a recombinant Newcastle disease virus expressing the glycoprotein of bovine ephemeral fever virus
Authors
Minmin Zhang
Jinying Ge
Zhiyuan Wen
Weiye Chen
Xijun Wang
Renqiang Liu
Zhigao Bu
Publication date
01-02-2017
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 2/2017
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-016-3078-2

Other articles of this Issue 2/2017

Archives of Virology 2/2017 Go to the issue

Original Article

The molecular epidemiological study of bovine leukemia virus infection in Myanmar cattle

Original Article

Roles of bta-miR-29b promoter regions DNA methylation in regulating miR-29b expression and bovine viral diarrhea virus NADL replication in MDBK cells

Annotated Sequence Record

Molecular identification of a new begomovirus infecting yellow passion fruit (Passiflora edulis) in Colombia

Brief Report

Characterization of a new carmovirus isolated from an Adonis plant

Brief Report

Epidemiology and etiology of hand, foot, and mouth disease in Fujian province, 2008-2014

Annotated Sequence Record

Characterization of a new begomovirus and betasatellite associated with chilli leaf curl disease in India
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits