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Graefe's Archive for Clinical and Experimental Ophthalmology
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 12/2013

01-12-2013 | Retinal Disorders

Characteristics of fundus autofluorescence and drusen in the fellow eyes of Japanese patients with exudative age-related macular degeneration

Authors: Shigeto Fujimura, Takashi Ueta, Hidenori Takahashi, Ryo Obata, R. Theodore Smith, Yasuo Yanagi

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 12/2013

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Abstract

Background

The main purpose of this study is to investigate the characteristics of fundus autofluorescence (FAF) and area of soft drusen among the fellow eyes of unilateral typical age-related macular degeneration (typical AMD) and polypoidal choroidal vasculopathy (PCV) in Japanese patients.

Methods

FAF images were obtained from the fellow eyes of unilateral typical AMD (n = 64), unilateral PCV (n = 95), unilateral retinal angiomatous proliferation (RAP) (n = 4) and 56 control subjects, then classified into normal, minimal-change, and abnormal patterns by two graders. Interobserver variability between two graders and intraobserver variability were assessed for FAF classifications, and cases with inconsistent decisions were finally classified by the third grader. Soft drusen were segmented and their total areas were compared between the fellow eyes of typical AMD and PCV. Area(s) with increased autofluorescence were segmented to assess the relationship with soft drusen area(s).

Results

Assessment for interobserver variability between two graders and intraobserver variability in one grader showed substantial agreement (κ = 0.70) and almost perfect agreement (κ = 0.85), respectively. In the final decision mediated by third grader, the proportions of eyes with either minimal-change FAF pattern or abnormal FAF pattern in the fellow eyes of both typical AMD (37 cases, 58 %) and PCV (47 cases, 49 %) were significantly higher than that of the control cases (15 cases, 27 %; p < 0.01). The proportion of abnormal FAF pattern in the fellow eyes of typical AMD (20 cases, 31 %) was higher than that of PCV (15 cases, 16 %; p < 0.05). Total soft drusen areas in the fellow eyes of typical AMD (0.369 ± 0.718 mm2) were larger than those of PCV (0.173 ± 0.408 mm2; p < 0.05), and those in the eyes with abnormal FAF pattern were larger than those with minimal-change FAF pattern or normal FAF pattern (p < 0.01). Image analysis revealed a relationship between increased autofluorescence and soft drusen, especially in the cases with large total soft drusen areas.

Conclusions

FAF characteristics were different between the fellow eyes of unilateral typical AMD and PCV in Japan, which might be due to the difference of total soft drusen areas between them.
Literature
1.
Maruko I, Iida T, Saito M, Nagayama D, Saito K (2007) Clinical characteristics of exudative age-related macular degeneration in Japanese patients. Am J Ophthalmol 144:15–22PubMedCrossRef
2.
Yannuzzi LA, Wong DW, Sforzolini BS, Goldbaum M, Tang KC, Spaide RF, Freund KB, Slakter JS, Guyer DR, Sorenson JA, Fisher Y, Maberley D, Orlock DA (1999) Polypoidal choroidal vasculopathy and neovascularized age-related macular degeneration. Arch Ophthalmol 117:1503–1510PubMedCrossRef
3.
Yannuzzi LA, Negrao S, Iida T, Carvalho C, Rodriguez-Coleman H, Slakter J, Freund KB, Sorenson J, Orlock D, Borodoker N (2001) Retinal angiomatous proliferation in age-related macular degeneration. Retina 21:416–434PubMedCrossRef
4.
Uyama M, Wada M, Nagai Y, Matsubara T, Matsunaga H, Fukushima I, Takahashi K, Matsumura M (2002) Polypoidal choroidal vasculopathy: natural history. Am J Ophthalmol 133:639–648PubMedCrossRef
5.
Ueta T, Iriyama A, Francis J, Takahashi H, Adachi T, Obata R, Inoue Y, Tamaki Y, Yanagi Y (2008) Development of typical age-related macular degeneration and polypoidal choroidal vasculopathy in fellow eyes of Japanese patients with exudative age-related macular degeneration. Am J Ophthalmol 146:96–101PubMedCrossRef
6.
Delori FC, Dorey CK, Staurenghi G, Arend O, Goger DG, Weiter JJ (1995) In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Investig Ophthalmol Vis Sci 36:718–729
7.
Weiter JJ, Delori FC, Wing GL, Fitch KA (1986) Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes. Invest Ophthalmol Vis Sci 27:145–152PubMed
8.
Dorey CK, Wu G, Ebenstein D, Garsd A, Weiter JJ (1989) Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci 30:1691–1699PubMed
9.
Heimes B, Lommatzsch A, Zeimer M, Gutfleisch M, Spital G, Bird AC, Pauleikhoff D (2008) Foveal RPE autofluorescence as a prognostic factor for anti-VEGF therapy in exudative AMD. Graefes Arch Clin Exp Ophthalmol 246:1229–1234PubMedCrossRef
10.
Hwang JC, Chan JW, Chang S, Smith RT (2006) Predictive value of fundus autofluorescence for development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci 47:2655–2661PubMedCentralPubMedCrossRef
11.
Bindewald A, Bird AC, Dandekar SS, Dolar-Szczasny J, Dreyhaupt J, Fitzke FW, Einbock W, Holz FG, Jorzik JJ, Keilhauer C, Lois N, Mlynski J, Pauleikhoff D, Staurenghi G, Wolf S (2005) Classification of fundus autofluorescence patterns in early age-related macular disease. Invest Ophthalmol Vis Sci 46:3309–3314PubMedCrossRef
12.
Spaide RF (2003) Fundus autofluorescence and age-related macular degeneration. Ophthalmology 110:392–399PubMedCrossRef
13.
Delori FC, Fleckner MR, Goger DG, Weiter JJ, Dorey CK (2000) Autofluorescence distribution associated with drusen in age-related macular degeneration. Invest Ophthalmol Vis Sci 41:496–504PubMed
14.
Midena E, Vujosevic S, Convento E, Manfre A, Cavarzeran F, Pilotto E (2007) Microperimetry and fundus autofluorescence in patients with early age-related macular degeneration. Br J Ophthalmol 91:1499–1503PubMedCentralPubMedCrossRef
15.
Smith RT, Chan JK, Busuoic M, Sivagnanavel V, Bird AC, Chong NV (2006) Autofluorescence characteristics of early, atrophic, and high-risk fellow eyes in age-related macular degeneration. Invest Ophthalmol Vis Sci 47:5495–5504PubMedCentralPubMedCrossRef
16.
Lois N, Owens SL, Coco R, Hopkins J, Fitzke FW, Bird AC (2002) Fundus autofluorescence in patients with age-related macular degeneration and high risk of visual loss. Am J Ophthalmol 133:341–349PubMedCrossRef
17.
von Ruckmann A, Fitzke FW, Bird AC (1997) Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci 38:478–486
18.
Obata R, Yanagi Y, Kami J, Takahashi H, Inoue Y, Tamaki Y (2006) Polypoidal choroidal vasculopathy and retinochoroidal anastomosis in Japanese patients eligible for photodynamic therapy for exudative age-related macular degeneration. Jpn J Ophthalmol 50:354–360PubMedCrossRef
19.
Jorzik JJ, Bindewald A, Dithmar S, Holz FG (2005) Digital simultaneous fluorescein and indocyanine green angiography, autofluorescence, and red-free imaging with a solid-state laser-based confocal scanning laser ophthalmoscope. Retina 25:405–416PubMedCrossRef
20.
Einbock W, Moessner A, Schnurrbusch UE, Holz FG, Wolf S (2005) Changes in fundus autofluorescence in patients with age-related maculopathy. Correlation to visual function: a prospective study. Graefes Arch Clin Exp Ophthalmol 243:300–305PubMedCrossRef
21.
Chen J, Tian J, Lee N, Zheng J, Smith RT, Laine AF (2010) A partial intensity invariant feature descriptor for multimodal retinal image registration. IEEE Trans Biomed Eng 57: 1707–1718PubMedCentralPubMedCrossRef
22.
Uyama M, Takahashi K, Ida N, Miyashiro M, Ando A, Takahashi A, Yamada E, Shirasu J, Nagai Y, Takeuchi M (2000) The second eye of Japanese patients with unilateral exudative age related macular degeneration. Br J Ophthalmol 84:1018–1023PubMedCentralPubMedCrossRef
23.
Davis MD, Gangnon RE, Lee LY, Hubbard LD, Klein BE, Klein R, Ferris FL, Bressler SB, Milton RC (2005) The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17. Arch Ophthalmol 123:1484–1498PubMedCrossRef
24.
Ishiko S, Akiba J, Horikawa Y, Yoshida A (2002) Detection of drusen in the fellow eye of Japanese patients with age-related macular degeneration using scanning laser ophthalmoscopy. Ophthalmology 109:2165–2169PubMedCrossRef
25.
Sivaprasad S, Membrey WL, Sivagnanavel V, Gonzalez JG, Liu DT, Chan WM, Lam DS, Jackson H, Chong NV (2006) Second eye of patients with unilateral neovascular age-related macular degeneration: Caucasians vs Chinese. Eye 20:923–926PubMedCrossRef
26.
27.
Cachulo L, Silva R, Fonseca P, Pires I, Carvajal-Gonzalez S, Bernardes R, Cunha-Vaz JG (2011) Early markers of choroidal neovascularization in the fellow eye of patients with unilateral exudative age-related macular degeneration. Ophthalmologica 225: 144–149
28.
Anderson DH, Talaga KC, Rivest AJ, Barron E, Hageman GS, Johnson LV (2004) Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration. Exp Eye Res 78:243–256PubMedCrossRef
29.
Li CM, Clark ME, Rudolf M, Curcio CA (2007) Distribution and composition of esterified and unesterified cholesterol in extra-macular drusen. Exp Eye Res 85:192–201PubMedCrossRef
30.
Mullins RF, Russell SR, Anderson DH, Hageman GS (2000) Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 14:835–846PubMed
Metadata
Title
Characteristics of fundus autofluorescence and drusen in the fellow eyes of Japanese patients with exudative age-related macular degeneration
Authors
Shigeto Fujimura
Takashi Ueta
Hidenori Takahashi
Ryo Obata
R. Theodore Smith
Yasuo Yanagi
Publication date
01-12-2013
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 12/2013
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-013-2363-y

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