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01-11-2012 | Thoracic Oncology

Characteristic Immunophenotype of Solid Subtype Component in Lung Adenocarcinoma

Authors: Teruhisa Takuwa, MD, Genichiro Ishii, MD, PhD, Kanji Nagai, MD, PhD, Junji Yoshida, MD, PhD, Mitsuyo Nishimura, MD, PhD, Tomoyuki Hishida, MD, PhD, Shinya Neri, MD, Seiki Hasegawa, MD, PhD, Atsushi Ochiai, MD, PhD

Published in: Annals of Surgical Oncology | Issue 12/2012

Abstract

Background

Lung adenocarcinomas represent a morphologically heterogeneous tumor composed of an admixture of different histologic subtypes (lepidic, papillary, acinar, and solid subtype). The presence of a solid subtype component is reported to be associated with a poorer prognosis. The aim of this study was to evaluate the characteristic immunophenotype of the solid subtype component compared with the immunophenotypes of other components.

Methods

We analyzed the clinicopathological characteristics of stage I adenocarcinoma patients with predominant solid subtype disease. Furthermore, we immunostained adenocarcinomas with predominant lepidic, papillary, acinar, and solid subtype components (n = 23 each) for 10 molecular markers of tumor invasiveness and scored the results.

Results

Patients showing predominance of the solid subtype component (solid subtype adenocarcinoma) had a poorer prognosis than those showing predominance of the lepidic, papillary, or acinar component. Lymphovascular invasion was more often detected in solid subtype tumors than in others. The solid subtype component showed a significantly stronger staining intensity of laminin-5 expression than the lepidic, papillary, and acinar components (P < 0.001, P < 0.001, and P = 0.016, respectively). The fibronectin and vimentin expression levels were also significantly higher in the solid subtype component than in other components. This immunostaining character was validated by using mixed-subtype adenocarcinomas containing all four components in the same tumor.

Conclusions

This study concluded that the solid subtype component in lung adenocarcinomas exhibit the invasive immunophenotype, including increased laminin-5 expression, compared with the other components, which may be associated with a poorer prognosis.

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Title: Characteristic Immunophenotype of Solid Subtype Component in Lung Adenocarcinoma
Authors: Teruhisa Takuwa, MD
Genichiro Ishii, MD, PhD
Kanji Nagai, MD, PhD
Junji Yoshida, MD, PhD
Mitsuyo Nishimura, MD, PhD
Tomoyuki Hishida, MD, PhD
Shinya Neri, MD
Seiki Hasegawa, MD, PhD
Atsushi Ochiai, MD, PhD
Publication date: 01-11-2012
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 12/2012
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-012-2428-x

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Springer Medicine

Characteristic Immunophenotype of Solid Subtype Component in Lung Adenocarcinoma

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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